Navigation Links
First High-Res 3-D Structures of Mammalian HSP90 Protein Solved, Key to Better Targets for AIDS, Sepsis, Cancer Drugs
Date:10/19/2007

HWI Scientist Dr. Dan Gewirth's Groundbreaking Research Makes Cover of

Molecular Cell

BUFFALO, N.Y., Oct. 19 /PRNewswire/ -- Dr. Dan Gewirth, Hauptman-Woodward senior research scientist, has just solved the structure of the first mammalian GRP94 protein implicated in immune diseases such as sepsis, AIDS and certain cancers. His work is being published today in a cover article in a top scientific journal -- Molecular Cell.

Gewirth's study confirms his 2001 hypothesis that this protein -- GRP94 -- is from the same family as the better known HSP90 proteins. As ligand-regulated chaperones -- proteins that help other cellular proteins achieve their active shapes, the HSP90s are key players in cellular regulation and recognition. The HSP90 proteins have been the subject of increasing international interest as scientists have discovered that they can be targeted therapeutically with drugs that lead to either stimulation as well as inhibition. For example, inhibitors of HSP90s are being developed as therapies for diseases ranging from cancer to sepsis, and drugs that stimulate HSP90 action may be appropriate therapies for diseases involving protein folding, such as cystic fibrosis, prion diseases, and Alzheimer's Disease.

Since 2001, Gewirth and his lab have been using the technique of X-ray diffraction to solve the first high-resolution structure of this protein from mammalian origins, to understand its function and to determine if it is indeed a member of the HSP90 family of proteins. The structure and activity patterns of this protein prove conclusively that this is indeed a member of the same family.

"Our work opens the door to a more intensive evaluation of this protein both from a mechanistic as well as a therapeutic point of view. In addition to aiding our understanding of the fundamental biology of chaperone-mediated protein folding, this work lays the foundation for the design of drugs that specificall
'/>"/>

SOURCE Hauptman-Woodward Medical Research Institute
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
2. Pixantrone Combination Therapy for First-line Treatment of Aggressive Non-Hodgkins Lymphoma Results in Reduction in Severe Toxicities Including Heart Damage When Compared to Doxorubicin-based Therapy
3. Genzyme Announces Data from First Phase 3 Study of Tolevamer in Patients with C. difficile Associated Diarrhea
4. Ablynx Announces Interim Results of First Nanobody Phase I Study of ALX-0081 (ANTI-VWF)
5. Advanced Life Sciences Announces Supplemental Efficacy Data from First Pivotal Phase 3 Pneumonia Clinical Trial
6. Advanced Life Sciences to Host Conference Call to Discuss Data From Cethromycins First of Two Phase 3 Pneumonia Trials
7. First Phase II Short-Term Study on Dapagliflozin Shows Results on Safety, Tolerability and Glycemic Markers in Subjects With Type 2 Diabetes
8. Advanced Cell Technology Develops First Human Embryonic Stem Cell Line without Destroying an Embryo
9. First Demonstration of nanoImmunology: a Nanomaterials-based Therapeutic Approach to Treat Allergy
10. First single breast cancer study to show significant survival benefit for women switching from tamoxifen to Arimidex
11. Mymetics HIV Vaccine Demonstrates First-Ever Production of Neutralizing IgA Antibodies in Non-Human Primate Model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... -- Today, UBM China, a wholly owned subsidiary of ... Exhibition Co., Ltd. to jointly run the Health Expo ... concurrently with CWMEE 2016. This cooperation ... MEDTEC China and DENTECH China, and fills its blank ... also another concrete cooperative project in Chengdu ...
(Date:6/30/2015)... , June 30, 2015 ... ), a clinical-stage pharmaceutical Company focused on the development ... first patient has been screened in the Company,s Phase ... U.S. based study will be performed under the active ... U.S. Food and Drug Administration (FDA). The ...
(Date:6/30/2015)...  July 4 th is this weekend, a time ... and people behind it. To help honor our current nation,s ... USA Medical Card, a leading provider of free ... empower independence for our disabled military veterans, police, firemen, and ... their prescriptions. "Due to USA ...
Breaking Medicine Technology:UBM Joins Chengdu Tianyi to Hold CWMEE 2016 2UBM Joins Chengdu Tianyi to Hold CWMEE 2016 3Oramed Enrolls First Patient in its Phase IIb Oral Insulin Study 2Oramed Enrolls First Patient in its Phase IIb Oral Insulin Study 3Hope For Heroes and USA Medical Card Make a Difference for Our Nation's Heroes 2
(Date:6/30/2015)... ... June 30, 2015 , ... James C. ... & Sarcoma surgery at HackensackUMC and Director of the Skin and Sarcoma division ... distribution of his online Orthopedic Oncology and Pathology Course. The newly installed ...
(Date:6/30/2015)... Louis, MO (PRWEB) , ... June 30, 2015 ... ... attorneys handling national testosterone claims alleging heart attack and stroke incidents are linked ... after Independence Day. The Case Management Conference is scheduled for July 9, 2015, ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... partnership with Knockout Zone Miami (KO Zone), a state-of-the-art training ... and CrossFit Coach, Diego de Vera. The partnership will provide KO Zone clients ...
(Date:6/30/2015)... ... June 30, 2015 , ... Amerec, a division of TyloHelo Inc, is pleased ... Daily is now approved by the Interior Design Continuing Education Council for 1 credit ... overview and explanation of what sauna, steam, and far-infrared saunas are, where they are ...
(Date:6/30/2015)... ... 30, 2015 , ... New Xarelto lawsuit claims proposed for ... new forms, according to attorneys handling Xarelto lawsuits included in the ... “provide guidance” for plaintiffs’ attorneys in filing new claims, according to court documents. ...
Breaking Medicine News(10 mins):Health News:NJ Top Doc, Dr. James C. Wittig, has Enhanced his Education Portal on TumorSurgery.org 2Health News:NJ Top Doc, Dr. James C. Wittig, has Enhanced his Education Portal on TumorSurgery.org 3Health News:Testosterone Lawsuit News: July Conference on Bellweather Trials 2Health News:Testosterone Lawsuit News: July Conference on Bellweather Trials 3Health News:Testosterone Lawsuit News: July Conference on Bellweather Trials 4Health News:Top Sports Nutrition Brand, Liporidex, Announces Partnership With Leading Boxing, CrossFit and MMA Gym, Knockout Zone of Miami 2Health News:Top Sports Nutrition Brand, Liporidex, Announces Partnership With Leading Boxing, CrossFit and MMA Gym, Knockout Zone of Miami 3Health News:Amerec’s Steam and Sauna Continuing Education Course Now Approved for Interior Design Credit 2Health News:Xarelto Lawsuit News: New Xarelto Lawsuit Filings to Be Expedited 2Health News:Xarelto Lawsuit News: New Xarelto Lawsuit Filings to Be Expedited 3
... or engineer? Sex hormones strongly influence people,s interests, ... according to psychologists. , "Our results provide strong ... characterized by working with things versus people," said ... with Sheri A. Berenbaum, professor of psychology and ...
... 1 (HealthDay News) -- The intensity of exercise, not the ... of living a longer life, a new study suggests. ... with high levels of cycling intensity lived 5.3 years longer, ... men with low intensity. Among female cyclists, those with ...
... IL A natural yellowing of the eye lens that absorbs ... of test volunteers, according to a,study in the September 1 issue ... discoloration worsened with age, so did the risk of insomnia. ... why sleep disorders become more frequent with increasing age," said Line ...
... hospitalization rates in adolescents and young adults aged 15 ... 2008 according to a study conducted by researchers at ... findings available today in Annals of Neurology , ... Child Neurology Society, report an increase in the prevalence ...
... the September issue of the Journal of the American ... in chest computed tomography (CT) scans. Chest CT is the ... the cause of clinical signs or symptoms of the chest, ... Regardless of the body region being scanned, dose ...
... , WEDNESDAY, Aug. 31 (HealthDay News) -- New research ... files could greatly improve care for diabetic patients by ... faster" at various kinds of medical clinics that had ... Cebul, a professor of medicine at Case Western Reserve ...
Cached Medicine News:Health News:Sex hormones impact career choices 2Health News:Aging eyes linked to sleepless nights, new study shows 2Health News:Increased prevalence of stroke hospitalizations seen in teens and young adults 2Health News:Electronic Medical Records Might Boost Diabetes Care 2Health News:Electronic Medical Records Might Boost Diabetes Care 3
Carl Zeiss immersion oils are PCF free. They are quality controlled for two wavelengths of light, Ne=1.518 and Nd=1.515 at 23ºC....
Immersion oils may crystallize on storage. Can be redissolved on heating to 50ºC (1-2 hours)...
... Oils are the standard - the ones to ... Laboratories has consistently led in the development and ... Here is the record: , When the FDA ... of In Vitro Diagnostics in the 1970's, Cargille ...
... an Informatics software product enabling quick and ... the laboratory. With SpecTRACK Software, users can ... specimen from all laboratories in their LAN ... or cold room. Automate your existing manual ...
Medicine Products: