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First Ever Study on Alzheimer's Disease Treatment in Hispanics Presented at Major Medical Meeting
Date:7/30/2008

ctive in detecting cognitive impairment and in the diagnosis of AD in Spanish-speaking individuals. The Symbol Digit Modality Test (SDMT) is also extremely sensitive for detecting dementia and has minimal cultural bias. A third, commonly used measurement included the Mini-Mental State Examination (MMSE).

The MMSE score, which measures cognitive function, significantly improved from baseline (p<0.0001) with a treatment effect that was similar to that seen in the pivotal studies for ARICEPT. The FOME, which assesses learning and memory through common object recognition, also showed significant improvement with ARICEPT (p=0.0042) in terms of retrieval scores. The FOME storage scores did not show statistically significant improvement from baseline. The SDMT measures speed of mental processing, attention and concentration functions, and also showed significant improvement from baseline (p<0.0001). Behavioral symptoms and associated caregiver distress were assessed with the Neuropsychiatric Inventory (NPI). A numeric improvement in NPI total score was observed but did not reach statistical significance; however, the NPI Caregiver Distress scale (NPI-D) total score significantly improved (p=0.0500).

The most common adverse events greater than or equal to five percent were insomnia (9.5 percent), dizziness (7.6 percent), diarrhea (5.7 percent) and nausea (5.7 percent).

"All too often, Hispanics dismiss the symptoms of AD as signs of normal aging and wait years before consulting a doctor," said Yanira Cruz, who has a doctorate in public health and is president and CEO of the National Hispanic Council on Aging (NHCOA), a national organization dedicated to improving the quality of life for Hispanic communities. "This study reminds us of the value of treating AD to slow symptoms of the disease, and I encourage primary care physicians with Hispanic patients to start screening for signs of dementia at a younger age, potentially at 55 or 60 years."

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SOURCE Eisai Inc.; Pfizer Inc
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