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First Ever Study on Alzheimer's Disease Treatment in Hispanics Presented at Major Medical Meeting
Date:7/30/2008

ARICEPT(R) (donepezil HCl tablets) Now the Only Alzheimer's Disease Drug

Studied in Two Minority Groups

CHICAGO, July 30, 2008 /PRNewswire/ -- Eisai Inc. and Pfizer Inc (NYSE: PFE) announced today results from a new open-label study that showed Hispanics with mild to moderate Alzheimer's disease (AD) experienced significant improvement in cognition compared to baseline after 12 weeks of treatment with ARICEPT. This is the first clinical trial looking at an AD prescription medication exclusively in Hispanics, and is important given the high risk of AD among this large population. These results are consistent with pivotal ARICEPT studies in the general population and also in studies specific to African Americans, as seen in the 2006 Treatment of Alzheimer's in African American Patients (TAAAP) study. The Evaluating ARICEPT Treatment in Hispanics (EARTH) study was presented at the 2008 Alzheimer's Association International Conference on Alzheimer's Disease and Related Disorders (ICAD).

"We know the Hispanic community is in need of increased education on the benefits of diagnosing and treating AD early," said Dr. Oscar Lopez, professor, department of neurology, University of Pittsburgh, and the first author of the EARTH poster presented at ICAD. "This news should serve as a call to action for Hispanic families to watch for early signs of AD among their loved ones and speak with a doctor as soon as possible if symptoms are suspected."

This multi-center open-label clinical trial enrolled 106 Hispanic men and women from across the U.S. Patients were at least 50 years of age and had a diagnosis of mild to moderate AD. In order to most accurately measure the efficacy of ARICEPT in Hispanics, unique measurement tools with little language bias were specifically selected for use in the EARTH study. For instance, the Fuld Object Memory Evaluation (FOME) assessment reduces dependence on spoken English, and it has been proven effe
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SOURCE Eisai Inc.; Pfizer Inc
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