Navigation Links
First Clinical Experience With Soliris(R) in Treating Patients With Two Rare Complement-Mediated Diseases Presented at ASH Annual Meeting
Date:12/7/2008

CHESHIRE, Conn., Dec. 7 /PRNewswire-FirstCall/-- Soliris(R) (eculizumab), a terminal complement inhibitor developed by Alexion Pharmaceuticals, Inc. (Nasdaq: ALXN) for the treatment of paroxysmal nocturnal hemoglobinuria (PNH), was associated with an improvement in hematologic parameters in a limited number of patients with two other rare and severe complement-mediated diseases treated outside of a clinical trial, according to patient cases presented today at the 50th Annual Meeting of the American Society of Hematology (ASH).

Physicians reported on the first clinical experience with Soliris in patients with atypical Hemolytic Uremic Syndrome (aHUS) and Cold Agglutinin Disease (CAD), two rare and serious diseases. Like patients with PNH, patients with aHUS are missing or have defective complement inhibitors that help to regulate the body's immune system. These patients suffer from hemolysis, blood clotting which can be measured in part as reduced number of circulating platelets, and kidney damage. In two patients with aHUS, Soliris administration was associated with improvements in platelet levels and reduction in hemolysis. Patients with CAD suffer from an autoimmune attack on their red blood cells leading to severe complement activation and hemolysis (destruction of those blood cells), anemia, and poor quality of life. In one patient with CAD, Soliris treatment was associated with reduced hemolysis, absence of the need for blood transfusions and improved symptoms of fatigue and anemia. Eculizumab appeared to be well tolerated in these patients, with safety observations that were consistent with those reported from controlled trials in patients with PNH.

"We are encouraged by this initial clinical experience with eculizumab in a very limited number of aHUS and CAD patients. These observations and other knowledge of
'/>"/>

SOURCE Alexion Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. CVBT Doses First Patient in its Phase II Clinical Trial for Severe Coronary Heart Disease
2. FDA Approves Promacta(R) (Eltrombopag), the First Oral Medication to Increase Platelet Production for People With Serious Blood Disorder
3. Celator(R) Pharmaceuticals Announces Enrollment of First Patient in Phase 2 Study with CPX-351
4. Alba Therapeutics Announces Enrollment of Its First European Patient in Global Phase IIb Study of Larazotide Acetate for Treatment of Active Celiac Disease
5. Roche, InterMune and Pharmasset Announce Initiation of INFORM-1, the First Dual-Combination Clinical Trial with Oral Antivirals in Hepatitis C
6. Diagenic Announces Launch of First Breast Cancer Gene-Expression Blood Test
7. Zevalin(R) Following Short-Course Chemotherapy with CHOP + Rituximab (CHOP-R) Doubles Complete Remission Rate in First-Line Treatment of Follicular Non- Hodgkins Lymphoma
8. Celladon Announces Presentation of Clinical Data From First-in-Human MYDICAR(R) Trial for Advanced Heart Failure at American Heart Association Scientific Sessions
9. Sequoia Pharmaceuticals Presents In Vitro and First-in-Human Data Supporting Further Development of SPI-256, a Novel Investigational Protease Inhibitor
10. ULURU Inc. Announces the Commencement of First Clinical Study Using Altrazeal(TM) Silver
11. First Town Hall Meeting on Inequities in Clinical Trials to Take Place at the Harlem Hospital Center on October 20
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... 1, 2015 Boston Scientific Corporation (NYSE: BSX ... business highlights for the second quarter ended June 30, 2015 ... The call will be hosted by Mike Mahoney ... , executive vice president and chief financial officer. ... via the Boston Scientific website. Webcast registration is available on ...
(Date:7/1/2015)... July 1, 2015   Continental Clinical Solutions (Continental) announced it is expanding its ... to accommodate increased volume in clinical studies and demand for unique patient populations.  ... ... ... ...
(Date:7/1/2015)... 2015 New exchange plan enrollees spent less ... to the same time a year ago, according to ... ESRX ) Exchange Pulse™ report, released today. ... number of new exchange plan enrollees who used at ... first quarter of 2015. However, when evaluating exchange plan ...
Breaking Medicine Technology:Boston Scientific To Webcast Second Quarter 2015 Earnings Call On July 23 2Continental Clinical Solutions CEO Saleh Stevens Eyes Growth 2Continental Clinical Solutions CEO Saleh Stevens Eyes Growth 3Continental Clinical Solutions CEO Saleh Stevens Eyes Growth 4Express Scripts Provides First Look at 2015 Public Exchange Pharmacy Trends 2Express Scripts Provides First Look at 2015 Public Exchange Pharmacy Trends 3Express Scripts Provides First Look at 2015 Public Exchange Pharmacy Trends 4Express Scripts Provides First Look at 2015 Public Exchange Pharmacy Trends 5
... Unilife Corporation ("Unilife" or the "Company") (NASDAQ: ... its management team. These senior appointments will support Unilife ... ready-to-fill (prefilled) syringe to a number of pharmaceutical and ... other pipeline devices within the Company,s rapidly expanding portfolio ...
... InspireMD, Inc. (OTC BB: NSPR) ... mesh protective stent system, today announced the election of ... S. Stuka, Managing Member of Osiris Partners and a 30-year ... former executive of several Israeli firms sold to larger companies ...
Cached Medicine Technology:Unilife Expands Management Team to Support Business Growth 2Unilife Expands Management Team to Support Business Growth 3Unilife Expands Management Team to Support Business Growth 4Unilife Expands Management Team to Support Business Growth 5Unilife Expands Management Team to Support Business Growth 6InspireMD Elects Two New Board Members 2InspireMD Elects Two New Board Members 3InspireMD Elects Two New Board Members 4InspireMD Elects Two New Board Members 5
(Date:7/1/2015)... Los Angeles, CA (PRWEB) , ... July 01, 2015 , ... ... enjoy the great outdoors. Yet, in many Middle-Eastern countries like Saudi Arabia and Dubai, ... entirely to relax in more temperate climates. Celebrity dentist Dr. Sam Saleh of ORA ...
(Date:7/1/2015)... ... July 01, 2015 , ... For decades, researchers in the genetics field have ... the brain, never changing after development in the womb. Now, researchers from the Icahn ... brain cells throughout life – a process which helps to switch genes on and ...
(Date:7/1/2015)... ... July 01, 2015 , ... A healthy eating plan concentrates ... eggs. Eating organic foods and products can help limit the exposure to pesticides ... production chicken farming. Choosing home raised chickens and eggs that do not contain ...
(Date:7/1/2015)... ... July 01, 2015 , ... OncLive® ... Hospital Corporation of America (HCA), as it further expands its Strategic Alliance Partnership ... , With this new partnership, OncLive’s editorial and marketing teams will collaborate with ...
(Date:7/1/2015)... ... July 01, 2015 , ... Lisa Keys, the widow of U.S. Army Master ... Keys’ birthday) in memory of her late husband and all of America’s fallen military ... Bronze Star Medal, died during a Special Forces training exercise in December of 2012. ...
Breaking Medicine News(10 mins):Health News:Dr. Sam Saleh Invites Vacationing International Patients to Get a Same-Day Hollywood Smile During the July Travel Season 2Health News:Mount Sinai Researchers Discover New Epigenetic Mechanism in Brain Cells 2Health News:Mount Sinai Researchers Discover New Epigenetic Mechanism in Brain Cells 3Health News:Mount Sinai Researchers Discover New Epigenetic Mechanism in Brain Cells 4Health News:Chicken Coop Condo Offer New Chicken Coop Designs 2Health News:OncLive® Welcomes Sarah Cannon Cancer Network to Its Strategic Alliance Partnership Program 2Health News:OncLive® Welcomes Sarah Cannon Cancer Network to Its Strategic Alliance Partnership Program 3Health News:Wife of Fallen Special Forces Soldier to Host Nationwide ‘Virtual 5K’ for Charity 2Health News:Wife of Fallen Special Forces Soldier to Host Nationwide ‘Virtual 5K’ for Charity 3
... Vista Partners announced today,that it has initiated coverage ... AAHx). "Cash on hand and royalty,revenue alone are equal ... our,US$0.43 probability weighted, DCF value for ART621 and you ... price. This comes without assigning any,value to their current ...
... LAKE CITY, March 18 Quixtar North America ... Inc. and MonaVie,LLC), and several MonaVie distributors for ... The Complaint alleges that MonaVie competes,unfairly by making ... blend products featuring acai berries through a network ...
... The regimen is less challenging for patients but equally ... March 18 (HealthDay News) -- The use of ... be just as effective as conventional doses for women ... Because fewer treatments are needed, the overall amount of ...
... Seeks Harmonization of Regulatory Structures, U.S. Secretary ... Private Sector to ,Lead Change, to Ensure Safety/Quality, ... Council (USIBC) hosted the Honorable Michael O. Leavitt,Secretary, ... Leavitt,shared with Industry leaders his observations from his ...
... we start filing our,taxes and realize just how much money ... help but wander onto the subject of how we can ... 2008. If you enjoy fitness and,an active lifestyle, you may ... addition to typically making more money than personal trainers,employed by ...
... full Senate, moves to House, PHOENIX, March 18 ... Medicaid program to expend moneys to provide,smoking cessation treatments ... of 27 to 3., Currently, Arizona is one ... programs in the state,s Medicaid program, which in,Arizona is ...
Cached Medicine News:Health News:Vista Partners Initiates Coverage on Arana Therapeutics (ASX: AAH; AIM: AAHx) 2Health News:Quixtar Files Suit Against MonaVie To Protect Consumers, Halt Unfair Competition 2Health News:Breast Cancer Radiation Therapy Works in Fewer, But Higher Doses 2Health News:U.S.-India Business Council Mobilizes Coalition for Healthy India 2Health News:Recession Proof Yourself With Education 2Health News:Arizona Senate Approves Smoking Cessation Treatments for State Medicaid Beneficiaries 2
Anesthetists Precordial Kit incudes one set of 4 chromed plated chest pieces, a reusable monoscope of your choice, and 20 precordial adhesive discs....
"Comfort Fit" Precordial Monoscope is manufactured from latex free non-toxic PVC. The monscope facilitates to either ear and adapts easily to chest piece luer fitting....
For accurately monitoring heart and breath sounds....
For accurately monitoring core temperature and heart and breath sounds....
Medicine Products: