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First Candidate from Esperance's Targeted Anti-cancer Platform, EP-100, Establishes Preclinical Proof of Concept
Date:4/21/2009

- Company plans initiation of clinical studies; Data to be presented at AACR -

BATON ROUGE, La., April 21 /PRNewswire/ -- Drug discovery and development company Esperance Pharmaceuticals today presented positive results from the Company's preclinical program that support the initiation of clinical trials in cancer. EP-100 is the first candidate from the Company's Cationic Lytic Peptide (CLYP(TM)) platform technology. EP-100 is a targeted membrane-disrupting peptide and is designed to selectively target luteinizing hormone releasing hormone (LHRH) receptors, which are overexpressed in a wide range of cancers. Results from preclinical in vitro and in vivo studies of EP-100 in ovarian cancer cell lines and ovarian xenograft models were presented in a poster presentation entitled, "Targeted Oncolytic Peptide for Treatment of Ovarian Cancers" at the American Association for Cancer Research (AACR) Annual Meeting in Denver, CO.

(Logo: http://www.newscom.com/cgi-bin/prnh/20090421/NE02455LOGO )

Esperance is using its CLYP(TM) technology to develop a robust portfolio of small, novel oncolytic peptides to selectively destroy cancer cells that express target receptors. In addition to EP-100, the Company is developing several other drug candidates, all of which have a unique targeting mechanism of action whereby candidates bind specifically and exclusively to cancer cells that express the target receptors on their surfaces. The positively charged peptides disrupt the negatively charged membranes of the cancer cells, causing rapid cell death by lysis.

"These data not only support the continued development of EP-100, but also validate our core membrane-disrupting peptide platform technology," said Carola Leuschner, P
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SOURCE Esperance Pharmaceuticals, Inc.
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