Navigation Links
First Candidate from Esperance's Targeted Anti-cancer Platform, EP-100, Establishes Preclinical Proof of Concept
Date:4/21/2009

- Company plans initiation of clinical studies; Data to be presented at AACR -

BATON ROUGE, La., April 21 /PRNewswire/ -- Drug discovery and development company Esperance Pharmaceuticals today presented positive results from the Company's preclinical program that support the initiation of clinical trials in cancer. EP-100 is the first candidate from the Company's Cationic Lytic Peptide (CLYP(TM)) platform technology. EP-100 is a targeted membrane-disrupting peptide and is designed to selectively target luteinizing hormone releasing hormone (LHRH) receptors, which are overexpressed in a wide range of cancers. Results from preclinical in vitro and in vivo studies of EP-100 in ovarian cancer cell lines and ovarian xenograft models were presented in a poster presentation entitled, "Targeted Oncolytic Peptide for Treatment of Ovarian Cancers" at the American Association for Cancer Research (AACR) Annual Meeting in Denver, CO.

(Logo: http://www.newscom.com/cgi-bin/prnh/20090421/NE02455LOGO )

Esperance is using its CLYP(TM) technology to develop a robust portfolio of small, novel oncolytic peptides to selectively destroy cancer cells that express target receptors. In addition to EP-100, the Company is developing several other drug candidates, all of which have a unique targeting mechanism of action whereby candidates bind specifically and exclusively to cancer cells that express the target receptors on their surfaces. The positively charged peptides disrupt the negatively charged membranes of the cancer cells, causing rapid cell death by lysis.

"These data not only support the continued development of EP-100, but also validate our core membrane-disrupting peptide platform technology," said Carola Leuschner, P
'/>"/>

SOURCE Esperance Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Oakwood Surgeons Perform Worlds First 3D Surgery Without Special Glasses
2. Surveyed Neurologists Anticipate That Less Than 30 Percent of Their Use of Emerging Oral Agents in Multiple Sclerosis Will be in the First Line
3. PEAK Surgical Announces Completion of First PRECISE Clinical Study, Receipt of Medical Design Excellence Award for PEAK(R) Surgery System and Achievement of Over 1,000 Surgeries Using PEAK PlasmaBlade(TM)
4. Micromet Receives Milestone Payment for Filing of the First Clinical Trial Application for MT203
5. Pharmasset Initiates First Time in Human Study of PSI-7851 for the Treatment of Hepatitis C (HCV)
6. Video: Afinitor(R) Approved in US as First Treatment for Patients With Advanced Kidney Cancer After Failure of Either Sunitinib or Sorafenib
7. First Human Study to Show Sun Chlorella A Supports Heart Health
8. Nations Laboratory Response Network Marks First Decade of Protecting Public Health
9. First Year Results of the AXA Research Fund: Over Euro 13 Million Allocated for Research in 2008
10. Nobilon Advances First Vaccine Into Human Trials - Intranasal Influenza Vaccine Begins Phase I Clinical Development
11. CSL Behring Receives Orphan-Drug Exclusivity for RiaSTAP(TM), First and Only Approved Treatment of Acute Bleeding Episodes in Patients with Congenital Fibrinogen Deficiency
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... Jan. 15, 2014  Manufacturers, suppliers and distributors of ... to protect their most important business assets, intellectual ... ) Because of the highly-competitive nature ... one of the most litigious industry sectors of ...
(Date:1/15/2014)... Medical is very pleased to announce the appointment of Mr. ... Officer.  Mark was promoted from his current role of Chief ... facilities in Massachusetts , Mississippi ... in 2012 with 20+ years of broad-based operations, sales, engineering ...
(Date:1/15/2014)... , Jan. 15, 2014  Echo Therapeutics, Inc. (Nasdaq: ... its Symphony® CGM System as a non-invasive, wireless continuous ... Doman , Executive Chairman and Interim CEO of Echo ... Tenth Annual Equity Conference. Mr. Doman ...
Breaking Medicine Technology:Intellectual Property Insurance for Medical-related Products and Services 2Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3
(Date:4/18/2014)... device is being prepped to enter the battle ... of certain diseases in remote areas, thanks in ... investigations aboard the International Space Station on the ... concept of capillary flow to diagnose infectious diseases ... Ph.D., a researcher at Northwestern University in Evanston, ...
(Date:4/18/2014)... Hopkins University School of Medicine researchers have been awarded ... diabetes, Novo Nordisk announced this month. Of the 110 ... Obesity Biologics Science Forum Program, only four projects were ... researchers. They are Jonathan Powell, M.D., Ph.D.; G. William ... Jonathan Powell, a professor of oncology, will use his ...
(Date:4/18/2014)... a brain-related discovery that could revolutionize doctors, perception ... opens up the possibility that environmental and/or genetic ... activity that the researchers have identified as helping ... Neuroscience has just published a paper about ... of psychology and his doctoral student John Gaspar, ...
(Date:4/18/2014)... to potential new treatments for breaking the cycle of ... or scarring, is a hallmark of the disease, and ... to serious organ damage and, in some cases, death. ... findings made by Swati Bhattacharyya, PhD, research assistant professor ... protein plays in promoting fibrosis. , "Our results ...
(Date:4/17/2014)... first genetic variant specifically associated with the risk ... 10-15 per cent of all breast cancer cases. ... cancer sub-type, called invasive lobular carcinoma, gives researchers ... particular kind of breast cancer, which can be ... (Thursday) in the journal PloS Genetics , ...
Breaking Medicine News(10 mins):Health News:Space-tested fluid flow concept advances infectious disease diagnoses 2Health News:Space-tested fluid flow concept advances infectious disease diagnoses 3Health News:Scientists discover brain's anti-distraction system 2Health News:New clues on tissue scarring in scleroderma 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3
... long-term contract to provide medical billing services for the Seton Family ... delivering quality service and affordable medical billing solutions are cited in ... , ... Austin, Texas (PRWEB) May 10, 2009 -- ...
... Integrated Solution for Mail Server Data Protection and Quick Recovery ... ... CA and Melville, NY (PRWEB) May 11, 2009 -- MessageSolution, ... solutions for electronic discovery, litigation support, compliance and storage management, ...
... wipes are alcohol based. Over-use of hand sanitizers cause more health ... open a direct pathway to the human bloodstream. Q-Based Healthcare ... ... Erath, Louisiana (PRWEB) May 11, 2009 -- A Louisiana company, ...
... Released During National Women,s Health Week Points to Importance ... released today on gender-based differences in mental health shows ... suffer from major depression. The report addresses many ... trauma and violence can have on long term mental ...
... 11 , - New Hayfever Relief ... Available on the Internet , - With ... 200 years ago, however, it,s believed that,it now affects as many ... do suffer,with hayfever, it,s either complete misery with symptoms such as ...
... areas are more likely to develop late-stage cancer than those ... conclusion of a new study published in the June 15, ... the American Cancer Society. The study,s results indicate a need ... Diagnosing cancer at an early stage can improve outcomes. ...
Cached Medicine News:Health News:AMPM to Provide Medical Billing Services for Seton Community Health Centers in Austin 2Health News:MessageSolution and FalconStor Deliver Turnkey Solution for Enterprise Archiving, DR, and High-Availability 2Health News:MessageSolution and FalconStor Deliver Turnkey Solution for Enterprise Archiving, DR, and High-Availability 3Health News:MessageSolution and FalconStor Deliver Turnkey Solution for Enterprise Archiving, DR, and High-Availability 4Health News:MessageSolution and FalconStor Deliver Turnkey Solution for Enterprise Archiving, DR, and High-Availability 5Health News:Q-Based Healthcare Warns: Hand Sanitizers Increase Risk of Swine Flu Exposure 2Health News:Q-Based Healthcare Warns: Hand Sanitizers Increase Risk of Swine Flu Exposure 3Health News:Women at Greater Risk for Depression and Anxiety 2Health News:Women at Greater Risk for Depression and Anxiety 3Health News:'Qu-Chi' Acupressure Band Gives Hayfever Misery the Elbow 2Health News:'Qu-Chi' Acupressure Band Gives Hayfever Misery the Elbow 3Health News:City-dwellers have higher risk of late-stage cancer than rural residents 2
Eliminate preanalytical errors with automated QC module....
Non-invasive and continuous tcpCO2 and tcpO2 patient monitoring....
... Submit your analyzer data via the ... a worldwide peer group. , ... you to perform statistical analysis of ... often as you like. Peer-group data ...
Automated QC module...
Medicine Products: