Navigation Links
First AXL1717 Clinical Data From Ongoing Phase I/II Study in Cancer Patients has Been Published

First AXL1717 Clinical Data From Ongoing Phase I/II Study in Cancer Patients has... -- STOCKHOLM, September 7, 2010 /PRNewswire/ --

Advanced Search Search

  1. Send a release
  2. Member sign in
  3. Become a member
  4. For journalists
  5. Global sites
PR Newswire: news distribution, targeting and monitoring
  1. Products & Services
  2. Knowledge Center
  3. Browse News Releases
  4. Contact PR Newswire
Publishing & Information Services, Biotechnology, Medical Pharmaceuticals, Pharmaceuticals, New Products & Services, Clinical Trials & Medical Discoveries Click to view news release full screen  

First AXL1717 Clinical Data From Ongoing Phase I/II Study in Cancer Patients has Been Published


STOCKHOLM, September 7, 2010 /PRNewswire/ -- Axelar AB today announces that the first submitted medical article on the ongoing phase I/II cancer study with AXL1717 has been published in Acta Oncologica.

The article, including clinical data from a limited group of AXL1717-treated patients, by Drs. Ekman, Bergqvist, Frodin and colleagues, was recently published in Acta Oncologica, Early Online 1-7, 2010. The publication describes four heavily pretreated patients with progressive and advanced squamous non-small cell lung cancer (NSCLC) without any remaining therapeutic options. The patients were treated with AXL1717 for notably long time periods, and in addition to reporting that the drug was well tolerated the authors conclude that during: "more than seven months of AXL1717 treatment as third or fourth line treatment, the reported patients did not develop any additional metastases."

"We are pleased to report the first clinical experience in a peer-reviewed publication. These patients, with squamous NSCLC with tumor progression at baseline, represent a selected subgroup but lack a control group. We are encouraged by the results especially since the data was collected in a phase I setting with the primary objectives to establish the tolerability and pharmacokinetics of AXL1717. Squamous NSCLC is relatively unresponsive to regular cytotoxic chemotherapy but the cells of this cancer have been shown to display a high density of the IGF-1 receptor, the therapeutic target for AXL1717", says Johan Harmenberg, CEO Axelar AB.


About Axelar

Axelar AB is a Swedish biotech company founded in 2003. The company is developing insulin-like growth factor-1 (IGF-1) receptor inhibitors for treatment of cancer and other diseases. Axelar is part of the Karolinska Development portfolio of companies.

About AXL1717

Axelar's lead compound, AXL1717, provides a novel treatment regimen for a wide range of cancers. AXL1717 is the first targeted oral small-molecule IGF-1 receptor inhibitor with no effect on the insulin receptor. AXL1717 is presently undergoing phase I/II clinical trials and the compound combines a superior preclinical efficacy against numerous tumors with an excellent tolerability profile. Most tumor cells are dependent on the IGF-1 receptor signal pathway and the IGF-1 receptor is therefore regarded as a very promising target for cancer therapy. To date, there are no IGF-1 receptor inhibitor drugs on the market.

About Karolinska Development

Karolinska Development manages one of the largest portfolios of life science companies in Europe. Using a unique business model, the company cost efficiently guides the commercialization of world class life science innovations. Since its inception in 2003, Karolinska Development has built a portfolio of some 40 companies. Among the company's projects, 12 candidate drugs are undergoing clinical trials and it is estimated that a total of more than 20 substances have first-in-class potential.

For further information, please contact: Marek Poszepczynski, VP Business Development, Axelar AB Phone: +46(0)705-58-60-21, e-mail:

SOURCE Karolinska Development AB and Axelar AB
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. China Cord Blood Corporation to Announce First Quarter Fiscal 2011 Financial Results
2. First Aid Supplier HART Health Acquires Competitor and Continues Expansion
3. Abbott Receives FDA Approval for First Automated Molecular Test for Assessing Hepatitis B Treatment
4. Magic-Seal Packaging Products to Introduce First Vytex® Natural Rubber Latex Napkin Rings
5. Medisafe 1 Technologies Finalises Contract to Develop Prototype of the Worlds First Ever Medicinal Syringe-Locking Device
6. Swiss Breast Cancer Patient Becomes First in World to Receive Treatment Using Gated RapidArc from Varian Medical Systems
7. Elbit Imaging Announces Insightec Treats First Prostate Cancer Patients in Clinical Trials
8. Ascension Orthopedics Implants First PyroCarbon Shoulder Device in United Kingdom
9. BMP Sunstones Hao Wawa (Good Baby) Brand Ranked First Among Chinas Top Three Pediatric Medicine Brands
10. Cyberonics Reports Strong Fiscal 2011 First Quarter Results
11. Ambry Genetics Announces the Addition of Illumina HiSeq 2000 and First 510(K) Approved BeadXpress® to Its Sequencing and Genotyping Capabilities
Post Your Comments:
(Date:11/27/2015)... DUBLIN , Nov. 26, 2015 /PRNewswire/ ... announced the addition of the "2016 ... by Test, Country Volume and Sales Segment ... Emerging Opportunities" report to their offering. ... the addition of the "2016 Global ...
(Date:11/26/2015)... , 26 november 2015 ... kondigt de geplande investering aan van ten ... de laboratoria en het mondiale hoofdkantoor in ... uitbreiding zal resulteren in extra kantoorruimte en ... aan de groeiende behoeften van de farmaceutische ...
(Date:11/26/2015)... --> --> Juntendo University ... contrast weighting of MRI for patients with Multiple Sclerosis ... agreement with SyntheticMR in order to use SyMRI in clinical ... to generate multiple contrast images from a single scan and ... making it possible to both fine tune images and recreate ...
Breaking Medicine Technology:
(Date:11/29/2015)... , ... November 29, 2015 , ... Effective immediately, every ... In addition starting on Black Friday Target is offering a “Buy One Scrub Set, ... is a rare opportunity to purchase IguanaMed at a discounted price. , ...
(Date:11/28/2015)... ... 2015 , ... Safe storage for contraceptive devices may not always be easy ... Jersey and the other from Bradley Beach, New Jersey, there is an easy solution ... having to replace NuvaRings more often than necessary. As such, it affords peace of ...
(Date:11/28/2015)... ... November 28, 2015 , ... Pixel Film Studios is back ... to choose from, the possibilities are endless. Users have full control over angle of ... Pulse masking effects, users are sure to get heads to turn. , ProPanel: Pulse ...
(Date:11/27/2015)... Angeles, CA (PRWEB) , ... November 27, 2015 , ... ... study carried out by the University of Toronto and the University of British Columbia ... of hospitalizations for head injuries. The article explains that part of the reason for ...
(Date:11/27/2015)... ... ... A team of Swiss doctors has released a report on mesothelioma relapse ... the findings on the website. Click here to read the details now. ... who were treated with chemotherapy followed by EPP surgery. Among the 106 patients who ...
Breaking Medicine News(10 mins):