Navigation Links
First AXL1717 Clinical Data From Ongoing Phase I/II Study in Cancer Patients has Been Published
Date:9/7/2010

First AXL1717 Clinical Data From Ongoing Phase I/II Study in Cancer Patients has... -- STOCKHOLM, September 7, 2010 /PRNewswire/ --


Advanced Search Search

  
Close
  1. Send a release
  2. Member sign in
  3. Become a member
  4. For journalists
  5. Global sites
PR Newswire: news distribution, targeting and monitoring
  1. Products & Services
  2. Knowledge Center
  3. Browse News Releases
  4. Contact PR Newswire
Publishing & Information Services, Biotechnology, Medical Pharmaceuticals, Pharmaceuticals, New Products & Services, Clinical Trials & Medical Discoveries Click to view news release full screen  

First AXL1717 Clinical Data From Ongoing Phase I/II Study in Cancer Patients has Been Published

 

STOCKHOLM, September 7, 2010 /PRNewswire/ -- Axelar AB today announces that the first submitted medical article on the ongoing phase I/II cancer study with AXL1717 has been published in Acta Oncologica.

The article, including clinical data from a limited group of AXL1717-treated patients, by Drs. Ekman, Bergqvist, Frodin and colleagues, was recently published in Acta Oncologica, Early Online 1-7, 2010. The publication describes four heavily pretreated patients with progressive and advanced squamous non-small cell lung cancer (NSCLC) without any remaining therapeutic options. The patients were treated with AXL1717 for notably long time periods, and in addition to reporting that the drug was well tolerated the authors conclude that during: "more than seven months of AXL1717 treatment as third or fourth line treatment, the reported patients did not develop any additional metastases."

"We are pleased to report the first clinical experience in a peer-reviewed publication. These patients, with squamous NSCLC with tumor progression at baseline, represent a selected subgroup but lack a control group. We are encouraged by the results especially since the data was collected in a phase I setting with the primary objectives to establish the tolerability and pharmacokinetics of AXL1717. Squamous NSCLC is relatively unresponsive to regular cytotoxic chemotherapy but the cells of this cancer have been shown to display a high density of the IGF-1 receptor, the therapeutic target for AXL1717", says Johan Harmenberg, CEO Axelar AB.

TO THE EDITORS

About Axelar

Axelar AB is a Swedish biotech company founded in 2003. The company is developing insulin-like growth factor-1 (IGF-1) receptor inhibitors for treatment of cancer and other diseases. Axelar is part of the Karolinska Development portfolio of companies. http://www.axelar.se

About AXL1717

Axelar's lead compound, AXL1717, provides a novel treatment regimen for a wide range of cancers. AXL1717 is the first targeted oral small-molecule IGF-1 receptor inhibitor with no effect on the insulin receptor. AXL1717 is presently undergoing phase I/II clinical trials and the compound combines a superior preclinical efficacy against numerous tumors with an excellent tolerability profile. Most tumor cells are dependent on the IGF-1 receptor signal pathway and the IGF-1 receptor is therefore regarded as a very promising target for cancer therapy. To date, there are no IGF-1 receptor inhibitor drugs on the market.

About Karolinska Development

Karolinska Development manages one of the largest portfolios of life science companies in Europe. Using a unique business model, the company cost efficiently guides the commercialization of world class life science innovations. Since its inception in 2003, Karolinska Development has built a portfolio of some 40 companies. Among the company's projects, 12 candidate drugs are undergoing clinical trials and it is estimated that a total of more than 20 substances have first-in-class potential. http://www.karolinskadevelopment.com

For further information, please contact: Marek Poszepczynski, VP Business Development, Axelar AB Phone: +46(0)705-58-60-21, e-mail: marek.poszepczynski@axelar.se
'/>"/>

SOURCE Karolinska Development AB and Axelar AB
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. China Cord Blood Corporation to Announce First Quarter Fiscal 2011 Financial Results
2. First Aid Supplier HART Health Acquires Competitor and Continues Expansion
3. Abbott Receives FDA Approval for First Automated Molecular Test for Assessing Hepatitis B Treatment
4. Magic-Seal Packaging Products to Introduce First Vytex® Natural Rubber Latex Napkin Rings
5. Medisafe 1 Technologies Finalises Contract to Develop Prototype of the Worlds First Ever Medicinal Syringe-Locking Device
6. Swiss Breast Cancer Patient Becomes First in World to Receive Treatment Using Gated RapidArc from Varian Medical Systems
7. Elbit Imaging Announces Insightec Treats First Prostate Cancer Patients in Clinical Trials
8. Ascension Orthopedics Implants First PyroCarbon Shoulder Device in United Kingdom
9. BMP Sunstones Hao Wawa (Good Baby) Brand Ranked First Among Chinas Top Three Pediatric Medicine Brands
10. Cyberonics Reports Strong Fiscal 2011 First Quarter Results
11. Ambry Genetics Announces the Addition of Illumina HiSeq 2000 and First 510(K) Approved BeadXpress® to Its Sequencing and Genotyping Capabilities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... 2017 Transparency Market Research observes ... of 91.6% in the global capsule filler market in ... been leading the overall market for a significant time ... in handling sophisticated designs and manufacturing machines to manage ... research and development to deliver innovative products with new ...
(Date:1/24/2017)... Jan. 24, 2017   QR Pharma , ... developing novel therapies for the treatment of Alzheimer,s, ... appointment of four world-class key opinion leaders to ... join QR Pharma,s previous roster of impressive advisors ... to support the development of the breakthrough mechanism ...
(Date:1/24/2017)... -- The global  mammography market  is expected ... 2025, according to a new report by Grand View ... the rising initiatives by various governments and NGOs to ... breast tissue. Some significant organizations such as the National ... promoting the early diagnosis of mammary gland calcification, which ...
Breaking Medicine Technology:
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... Bellus Medical, ... company’s team of medical experts. In his new role Dr. Dobke will provide physician ... , Dr. Dobke is the Head of Plastic Surgery and Associate Professor of Surgery ...
(Date:1/24/2017)... Iowa City, IA (PRWEB) , ... January 24, 2017 , ... ... in the country, has taken great care to design a program that provides teachers ... language abroad and domestically. This online teaching certificate is ideal for post-baccalaureate students and ...
(Date:1/24/2017)... Pass, OR (PRWEB) , ... January 24, 2017 ... ... Gerald H. Pollack, Ph.D., http://www.faculty.washington.edu/ghp , Sharon Kleyne, the nation’s foremost ... of Water, Global Climate Change and Your Health on Voice America, once again ...
(Date:1/24/2017)... ... 24, 2017 , ... TopConsumerReviews.com recently gave a best-in-class 5 ... or PMS . , Most women of child-bearing age will experience the symptoms ... headaches, fatigue, and other discomfort. For some women, the effects are severe ...
(Date:1/24/2017)... ... January 24, 2017 , ... ... use to improve the connection with God. “Spiritual Vitamins: A Spiritual Energy Booster” ... Published by Christian Faith Publishing, Mathai Yohannan’s new book engages the mind and ...
Breaking Medicine News(10 mins):