Navigation Links
Findings on Bladder-Brain Link May Point to Better Treatments for Problems in Sleep, Attention
Date:7/29/2008

PHILADELPHIA, July 29 /PRNewswire-USNewswire/ -- Bladder problems may leave a mark on the brain, by changing patterns of brain activity, possibly contributing to disrupted sleep and problems with attention. For one in six Americans who have overactive bladder, the involuntary bladder contractions that often trigger more frequent urges to urinate, such mind-body connections may be of more than academic interest.

"We often tend to focus on just one organ, but here we see how an abnormal organ affects the whole organism," said behavioral scientist Rita J. Valentino, Ph.D., of The Children's Hospital of Philadelphia, who led the research describing how an overactive bladder altered nervous system activity in animals.

The study appeared in the July 21 online edition of the Proceedings of the National Academy of Sciences.

Overactive bladder, while it occurs in a variety of conditions in both adults and children, is especially prevalent among elderly men, in whom an enlarged prostate gland partially obstructs the flow of urine and makes bladder muscles contract involuntarily. Valentino's research team mimicked the condition in an animal model by surgically constricting the outlet of urine from rats' bladders.

Building on their previous investigations of the neural circuits between the bladder and the brain, the researchers found that two small brain structures, the Barrington's nucleus and the locus ceruleus, developed abnormal activity as a result of the bladder obstruction. In particular, the locus ceruleus showed persistently high activity, and this resulted in an abnormal electroencephalogram (EEG) recorded from the cortex, the broad mass of the brain that governs higher-level functions. In people, abnormally high activity in the cortex may result in disordered sleep, anxiety and difficulty in concentrating.

Valentino said further studies are necessary to analyze the direct connections between heightened brain activity and specific behaviors, but added that the brain circuits involving the locus ceruleus might be a useful target for drugs to improve attention and sleep patterns in patients with bladder dysfunctions.

Furthermore, she added, in addition to overactive bladder, other visceral diseases, such as irritable bowel disorder, may also affect the same neural circuitry, with similar neurobehavioral consequences.

The National Institutes of Health provided grant support for this research. Valentino's co-authors, all from The Children's Hospital of Philadelphia, were Stephen A. Zderic, M.D.; Elizabeth Rickenbacher, Madelyn A. Baez, Lyman Hale, and Steven C. Leiser.

About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country, ranking third in National Institutes of Health funding. In addition, its unique family-centered care and public service programs have brought the 430-bed hospital recognition as a leading advocate for children and adolescents. For more information, visit http://www.chop.edu.

CONTACT: John Ascenzi

Phone: (267) 426-6055

Ascenzi@email.chop.edu


'/>"/>
SOURCE The Children's Hospital of Philadelphia
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Halozyme Therapeutics Announces Positive Findings With Pegylated Enzyme in Prostate Cancer Models
2. FDA Updates Label for AVANDIA(R) to Include Clinical Findings Demonstrating Sustained Glycemic Control for Up to Five Years
3. Tengion Scientists Publish Key Preclinical Findings Demonstrating the Benefits of Organ Regeneration Vs. Repair
4. Study Findings Show Infection Control Intervention Helps Keep Kids in School
5. Landmark ATHENA Study Findings With Multaq(R) (dronedarone) Shows 24% Reduction In Cardiovascular Hospitalization or Death in Patients With Atrial Fibrillation
6. ISTA Pharmaceuticals Announces New Phase III Clinical Findings to Support Bepreve NDA Filing
7. ACORN Presents Findings of Collaborative Metastatic Colorectal Cancer Research
8. Halozyme Therapeutics Presents Findings on Combinations of rHuPH20 Enzyme With Bisphosphonates at the American Association for Cancer Research Conference
9. Mayo Clinic Proceedings Contributors Highlight Research Findings About Cardiovascular Benefits Associated With Omega-3 Fatty Acids
10. Recent Findings from the Framingham Offspring Study Show Low Numbers of LDL Particles (LDL-P) by NMR are Associated With Fewer Heart Disease Related Events than Equivalently Low Levels of LDL Cholesterol (LDL-C).(1)
11. Pharmacopeia Announces Additional Positive Findings from Phase 1 Multiple Ascending Dose Study of PS433540 (DARA)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... June 23, 2016  MedSource announced today that ... e-clinical software solution of choice.  This latest decision ... value to their clients by offering a state-of-the-art ... relationship establishes nowEDC as the EDC platform of ... full-service clients.  "nowEDC has long been a preferred ...
(Date:6/23/2016)... -- Research and Markets has announced the ... (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, ... Global Forecast to 2021" report to their offering. ... pharmaceutical excipients market is projected to reach USD 8.1 ... the forecast period 2016 to 2021. ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... Market Analysis 2016 - Forecast to 2022" report to ... report contains up to date financial data derived from varied ... major trends with potential impact on the market during the ... segmentation which comprises of sub markets, regional and country level ...
Breaking Medicine Technology:
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... ... 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida ... their peers for this recognition are considered among the top 2 percent of lawyers ... as members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark ...
(Date:6/24/2016)... ... ... of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum Wage’ ... 2020 and then adjusting it yearly to increase at the same rate as the median ... floor does not erode again, and make future increases more predictable. , The company is ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and the network’s ... the world, and the most handsome men, look naturally attractive. Plastic surgery should ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm Slone Partners is ... sequencing and genomics experience, as Vice President of North American Capital Sales at ... for leading the sales team in the commercialization of the HTG EdgeSeq system and ...
Breaking Medicine News(10 mins):