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Financial Assistance Now Available for People with Acute Lymphoblastic Leukemia
Date:6/27/2011

component of induction therapy for ALL, one dose of Oncaspar® achieved similar levels of asparagine depletion as six to nine doses of native L-asparaginase.

Oncaspar® allows patients to gain the full benefits of asparaginase therapy with less frequent dosing schedule compared with native L-asparaginase (nonPEGylated form).  Through the process of pegylation, the half-life of L-asparaginase is significantly increased and the L-asparaginase activity is sustained.  Oncaspar® is a registered trademark of Defiante Farmaceutica S.A.

Important Oncaspar® Safety Information:
Oncaspar® is contraindicated in patients with a history of serious allergic reactions to Oncaspar®, and in patients with a history of serious thrombosis, pancreatitis or serious hemorrhagic events with prior L-asparaginase therapy.

Oncaspar® should be discontinued in the case of anaphylaxis or serious allergic reactions, thrombosis or pancreatitis.  Glucose intolerance, in some cases irreversible, can occur. Coagulopathy can occur.  Perform appropriate monitoring.  The most common adverse reactions with Oncaspar® (> or = 2 percent) are allergic reactions (including anaphylaxis), hyperglycemia, pancreatitis, central nervous system (CNS) thrombosis, coagulopathy, hyperbilirubinemia and elevated transaminases.  

About Sigma-Tau Pharmaceuticals, Inc.:
Sigma-Tau Pharmaceuticals, Inc. is a U.S.-based, wholly owned subsidiary of the Sigma-Tau Group, and is dedicated solely to the global development and commercialization of medicines for patients with rare diseases.  Sigma-Tau Pharmaceuticals, Inc. is based in Gaithersburg, Md.  Since 1989, the company's products have been focused on rare diseases, including kidney disease, certain genetic disorders and cancers.  With more than 7,000 identified rare diseases that affect approximately 25 million patients in the
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SOURCE Sigma-Tau Pharmaceuticals, Inc.
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