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Filter Fails to Improve PCI Outcomes in Acute Coronary Syndromes
Date:3/30/2008

d. The windsock has multiple small holes to allow blood to flow through, but it catches larger debris. During PCI, the FilterWire is positioned in the coronary artery downstream of the lesion; both the device and any debris are removed after the procedure.

The A-F trial is the first randomized controlled trial to evaluate a vascular protection device in patients with NSTEMI acute coronary syndromes. For the study, Dr. Webster and his colleagues recruited 151 patients treated at 14 medical centers in New Zealand, Australia and Canada, randomly assigning them to protection with the FilterWire or to conventional PCI without vascular protection. The researchers found that the rates of major cardiovascular complications during hospitalization -- consisting of death, heart attack, emergency bypass surgery, or repeat procedure in the treated artery -- were no different in the two groups (12 percent in the FilterWire group vs. 10 percent in the control group). There were also no significant differences between the groups in the post-procedure release of enzymes that signal damage to the heart muscle.

"The device does not appear warranted for routine use in these patients," Dr. Webster said. "However, there are some patients who have major complications from distal embolism. We need better ways of identifying high-risk patients and lesions."

Dr. Webster will present the results of the "Angioplasty Balloon-Associated Coronary Debris and the EZ FilterWire" (A-F) study on Sunday, March 30 at 8:00 a.m. CDT in the Grand Ballroom, S100.

About SCAI

Headquartered in Washington, DC, the Society for Cardiovascular Angiography and Interventions is a 4,000-member professional organization representing invasive and interventional cardiologists in over 60 nations. SCAI's mission is to promote excellence in invasive and interventional cardiovascular medicine through physician education and representation, and advancement of quality standards to enhance pa
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