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Favourable Six Months Follow-Up Results From Intercell's Phase II Therapeutic Hepatitis C Program
Date:9/3/2008

udy arm conducted in 21 treatment-naive patients where the imiquimod application was omitted, did not show a significant reduction of the viral load. Thus the results strongly support the notion that the future co-administration of a TLR adjuvant, like IC31(R), is pivotal for the therapeutic effect of the vaccine.

"Our study is the first report to show significant long-term viral load effects of therapeutic vaccination. In particular the increasing RNA decline up to 6 months after vaccination is extremely encouraging and finally suggests the formulation of our vaccine with IC31(R), a strong TLR agonist. Furthermore our vaccine in future trials may be combined with standard therapy or novel antivirals." states Alexander von Gabain, Chief Scientific Officer of Intercell.

Although options for the treatment of chronic Hepatitis C with Interferon/Ribavirin have improved, treatment will remain very difficult and a significant unmet medical need, especially in the case of Genotype 1. Novel immunotherapies, and possibly therapeutic vaccines, might become an option in the arena of existing and future HCV combination treatments. Thus, Intercell will follow its development strategy that will also take advantage of an enlarged antigen portfolio and of IC31(R), Intercell's second-generation adjuvant that has recently demonstrated the generation of T-cell responses, in human vaccine trials, to a level not yet seen for other known adjuvants.

About Hepatitis C

HCV is a major cause of chronic liver disease, including cirrhosis and liver cancer. According to the World Health Organization (WHO), approximately 170 million people worldwide are chronic HCV carriers (3% of the world's population), including about 10 million Europeans, 3.9 million Americans and 2 million Japanese. 35,000 new infections occur in the United States alone each year. The substantial unmet medical need is underscored by the fact that each year 8,000 to 10,000 deaths and 1,000 liver tr
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SOURCE Intercell AG
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