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Fate Therapeutics' iPSC Technology Awarded Top Industry Honors for Small Molecule and Protein Reprogramming Breakthroughs
Date:12/21/2009

ethod to recapitulate human physiology for commercial scale drug discovery and therapeutic use. The Company has exclusively in-licensed from The Scripps Research Institute and the Whitehead Institute for Biomedical Research an intellectual property portfolio related to iPSC technology, including filings that date back to November 2003. This portfolio includes the latest techniques published by Dr. Sheng Ding in October 2009, which use three small molecules to generate iPSCs in a manner that is 200 times more efficient than and twice as fast as conventional methods for reprogramming adult human cells.

"Without using dangerous genetic manipulations associated with other methods of reprogramming, Fate Therapeutics has created a powerful platform for safer, more efficient reprogramming of human somatic cells," said Sandhya Kamath, senior research analyst at Frost & Sullivan. "Its protein-only approach to iPSC generation represents a true paradigm shift in reprogramming technology. By maintaining genetic fidelity, biologically-relevant model systems may be created to better understand diseases and to elucidate molecular targets for drug discovery."

In addition to establishing the leading industrialized platform for iPSC technology, Fate Therapeutics is advancing its pipeline of stem cell modulators, which includes FT1050 for the enhancement of hematopoietic stem cell (HSC) proliferation and homing. The small molecule is currently undergoing clinical testing at the Dana Farber Cancer Institute and Massachusetts General Hospital in adult patients with hematologic malignancies, such as leukemia and lymphoma, who have undergone nonmyeloablative conditioning therapy and are in need of HSC support. The Phase 1b study is intended to determine the safety and tolerability of introducing FT1050 during the standard course of dual umbilical cord blood transplant.

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