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Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support
Date:5/27/2009

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About Hematopoietic Stem Cell Support

Intensive chemotherapy, radiation, and/or immunotherapy are often used to treat patients with hematologic malignancies, such as leukemia and lymphoma, who have not been cured with conventional treatment. These high dose regimens designed to kill the cancer cells will also often destroy the patient's normal blood and immune systems in the process. Therefore, hematopoietic reconstitution through the administration of HSCs is necessary to restore normal bone marrow function. Also the immune cells generated by the HSCs, in some cases, play a role in eradicating cancer cells. Possible sources of HSCs include bone marrow, peripheral blood, or cord blood. The entire procedure is often referred to as hematopoietic stem cell support.

About Cord Blood Use in Hematopoietic Stem Cell Support

Human leukocyte antigen (HLA) typing is used to match patients and donors. To assure the highest rate of success, patients receiving a bone marrow or peripheral blood transplant must find a donor that matches at least five of the six HLA markers. Finding an unrelated donor match is limited by stringent matching criteria and is extremely difficult for ethnic populations, and delays in finding a match can severely impact patient outcome. An alternative is to use cord blood (CB), which extends the donor pool because as few as four of the six HLA markers need to match. CB has many other logistical and clinical advantages, including faster availability, lower incidence and severity of acute graft versus host disease, lower risk of transmitting infections by latent viruses, lack of donor attrition and no risk to the donor. CB is commonly used for pediatric patients; however, it is used less frequently for adults because two CB units are often necessary to supply sufficient HSCs for successful engraftment. The ability to increase CB engraftment rates could not only improve patient out
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SOURCE Fate Therapeutics, Inc.
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