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Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support
Date:5/27/2009

he worldwide registries. Because umbilical cord blood units are readily available from cord blood banks, and the matching criteria for cord blood are less stringent than with adult donors, the ability to increase cord blood use by enhancing its efficiency has the potential to help thousands of patients waiting for a match."

About FT1050 Phase 1b Study Design

The Phase 1b trial for FT1050 is expected to enroll twelve adult patients who are undergoing nonmyeloablative therapy with HSC support and will use two human umbilical cord blood (CB) units as the source of HSCs. The clinical trial protocol will involve pre-treating one of the two CB units with FT1050 for 60 minutes in an otherwise standard medical procedure, followed by the infusion of both the treated and untreated CB units to the patient. While the main goal of the Phase 1b study is to assess safety and tolerability, the clinical study will also track engraftment efficiencies and patient outcomes.

About FT1050

FT1050 is the first drug candidate from Fate Therapeutics' platform of Stem Cell Modulators (SCMs), small molecules and biologics that seek to modulate adult stem cells within the body to guide a desired outcome such as cell regeneration, healing or blocking cancer growth. In the case of HSCs, it has been demonstrated that stem cell pathways mediate the cells' ability to home to the bone marrow and eventually repopulate the patient's blood and immune system. Because FT1050 is believed to affect fundamental pathways present in all HSCs, FT1050 could improve the efficiency and success of treatment with HSCs from any source, including from bone marrow and peripheral blood. FT1050 was discovered by Leonard Zon, M.D., director of the Stem Cell Program at Children's Hospital Boston and a scientific founder of Fate Therapeutics and is part of an exclusive license granted to Fate by Children's Hospital Boston and Massachusetts General Hospita
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SOURCE Fate Therapeutics, Inc.
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