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Farletuzumab Data Presented on Phase II Clinical Trial in First-Relapsed Ovarian Cancer Subjects
Date:9/24/2009

ort our commitment to continue to develop farletuzumab for ovarian cancer," said Nicholas C. Nicolaides, Ph.D., President and CEO of Morphotek. "Our research with farletuzumab is consistent with our human health care (hhc) mission - addressing unmet medical needs by developing new treatment options that will improve the lives of patients."

Study Details

The primary objectives of the open-label Phase II study included: to measure overall response rate (ORR), to compare the length of a subject's second remission with her first remission and to measure change in CA-125 level.( )Approximately 20 centers in the United States, Germany and the Netherlands participated in the study.

Thirty-nine (88.6%) of the 44 eligible subjects receiving farletuzumab in combination with platinum and taxane had their CA-125 blood levels normalized, and three additional subjects had a 50% decrease.( )(According to the National Cancer Institute, CA-125 is a tumor marker frequently elevated in ovarian cancer. It is typically used to evaluate tumor response, as CA-125 levels generally correlate with tumor activity.) In nine (20.5%) of these 44 subjects, the second remission was equal to or longer than the first remission.

About Ovarian Cancer

Ovarian cancer forms in the tissue of the ovary. Most ovarian cancers are epithelial carcinomas (cancer that begins in the cells on the surface of the ovary).

Ovarian cancer, which ranks fifth as the cause of cancer deaths in women, usually grows asymptomatically before it is discovered. In Europe, it is estimated that there are 61,000 cases of ovarian cancer each year. The National Cancer Institute estimates that there were 21,550 new cases of ovarian cancer in the United States in 2009 and 14,600 deaths from the disease.

About Farletuzumab

Farletuzumab (MORAb-003) is a humanized monoclonal antib
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SOURCE Morphotek(R), Inc.
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