Navigation Links
FLAG Therapeutics and Duquesne University Announce Exclusive Worldwide Licensing Agreement for Novel, Dual-action Targeted Oncology Compounds
Date:12/4/2013

RALEIGH, N.C. and PITTSBURGH, Dec. 4, 2013 /PRNewswire/ -- FLAG Therapeutics Inc. and Duquesne University today announced an exclusive worldwide licensing agreement for two novel classes of small molecule, water-soluble drugs designed to target and destroy cancer cells: anti-angiogenic/anti-tubulin (AA/AT) compounds and folate-targeted anti-cancer (FTAC) compounds. The agreement represents one of the largest licensing ventures in Duquesne's history and encompasses the career portfolio of renowned cancer researcher and Duquesne professor Dr. Aleem Gangjee.  A vast library of compounds and an intellectual property portfolio protected by over 50 US and international patents and patent applications are included in the deal.

(Logo: http://photos.prnewswire.com/prnh/20131204/CL26584LOGO )

The AA/AT compounds included in the agreement are the first compounds ever to combine the dual-action of the two major classes of anti-cancer drugs into a single molecule.  An emerging understanding of tumor vasculature highlights the importance of simultaneously attacking tumors with both drugs, but current treatment combination regimens often miss the window of opportunity due to different dosing schedules and pharmacokinetics.  FLAG Therapeutics' dual acting AA/AT compounds deliver a simultaneous anti-angiogenic and anti-tubulin assault on the tumor.  By attacking the tumor when it is most vulnerable, FLAG hopes to increase drug efficacy while decreasing the potency of the anti-tubulin activity for improved tolerability.  In addition, FLAG's AA/AT compounds are designed to circumvent the two major mechanisms of drug resistance (P-glycoprotein (PGP) and β-III tubulin overexpression) that limit the utility of
'/>"/>

SOURCE FLAG Therapeutics Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Initial Data from Lightlake Therapeutics Joint Clinical Trial with NIDA Shows Nasal Delivery of Naloxone for Opioid Overdose as a Promising Treatment
2. Dual Chamber Syringes & Injectors. Devices, Therapeutics, Markets and Forecasts
3. Updated Presentation Time: Mirati Therapeutics to Present at the 25th Annual Piper Jaffray Healthcare Conference
4. Nora Therapeutics to Present at the Oppenheimer 24th Annual Healthcare Conference
5. Lorus Therapeutics Completes New Executive Management Team
6. Orexigen Therapeutics to Present at the 25th Annual Piper Jaffray Healthcare Conference
7. Halozyme Therapeutics To Present At The Piper Jaffray Healthcare Conference
8. Cardinal Health, Prime Therapeutics Renew Primary Distribution Agreement
9. Potential Acquisitions and Stock Price Updates - Research Report on BioMarin, Covidien, United Therapeutics, Brookdale, and Seattle Genetics
10. Mast Therapeutics To Present At The 25th Annual Piper Jaffray Healthcare Conference On December 3
11. Northwest Biotherapeutics Completes Public Offering Of Common Stock And Warrants; Underwriter Exercises Full Over-Allotment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... and ST. LOUIS , May ... pressure or high cholesterol may achieve better health outcomes ... according to early results of a unique program conducted ... ESRX ). "Pharmacists are one of the ... interactions with our members presents enormous opportunities to positively ...
(Date:5/5/2015)... 2015 Big Market Research presents a detailed ... Europe , ( France , Germany ... , UK) and Japan . Current scientific views ... provides the 5-year test volume and sales forecasts by country for ... Anti-HAV, Hepatitis Delta, HBc Ag, HBe Ag, and ALT/SGPT tests performed ...
(Date:5/5/2015)... 2015 E-QURE (Electric Quick Ulcer ... premier provider of innovative medical devices in the field ... to shareholders and the investment community, covering 2014 - ... the proprietary Bioelectrical Signal Therapy™ (BST) Device for advanced ... as well as its plans for commercialization and sale ...
Breaking Medicine Technology:SCAN Health Plan, Express Scripts' Quality Network Improves Medicare Beneficiary Health 2SCAN Health Plan, Express Scripts' Quality Network Improves Medicare Beneficiary Health 3SCAN Health Plan, Express Scripts' Quality Network Improves Medicare Beneficiary Health 42015 Opportunities in the Global Hepatitis Diagnostic Testing Market: Big Market Research 22015 Opportunities in the Global Hepatitis Diagnostic Testing Market: Big Market Research 3E-QURE Corp. Issues 2014 - 2015 Update to Shareholders 2E-QURE Corp. Issues 2014 - 2015 Update to Shareholders 3E-QURE Corp. Issues 2014 - 2015 Update to Shareholders 4E-QURE Corp. Issues 2014 - 2015 Update to Shareholders 5
(Date:5/5/2015)... (PRWEB) May 05, 2015 AxoGen, ... focused on the $1.6 billion peripheral nerve repair market, ... quarter ended March 31, 2015 compared to $3.14 million ... continued adoption of our proprietary portfolio of nerve repair ... and AxoGuard® Nerve Protector – and our solid sales ...
(Date:5/5/2015)... The 2015 Crystal Ball, hosted by the Hepatitis ... outreach and patient advocacy programs. The gala evening included dancing, ... hundreds of supporters. , The 2015 gala was dedicated to ... virus (HBV) by Dr. Baruch S. Blumberg, who passed away ... for his discovery of the virus in 1976. He and ...
(Date:5/5/2015)... (PRWEB) May 05, 2015 Baptist Medical ... Commission on Cancer (CoC) of the American College of ... program must meet more than 30 Commission on Cancer ... a survey process, and maintain levels of excellence in ... When patients choose to seek care locally at a ...
(Date:5/5/2015)... " QuickPick Travel ” was featured on NewsWatch as ... small, medium, and large businesses making an impact in their ... expert, conducted the business review and shared with viewers how ... weeks of vacation for free. , Vacations are a sought-after ... world. And when people are preparing for vacations, they’re used ...
(Date:5/5/2015)... 2015 ProTexting, LLC – a ... deploy Mobile Engagement Campaigns and other Mobile solutions, introduces ... can now leverage the power of Mobile Marketing to ... subscribers’ e-mail addresses into the Constant Contact Platform. , ... the growing trend of multi-channel marketing would become more ...
Breaking Medicine News(10 mins):Health News:AxoGen, Inc. Reports 58% Year-Over-Year Revenue Growth for the 2015 First Quarter 2Health News:AxoGen, Inc. Reports 58% Year-Over-Year Revenue Growth for the 2015 First Quarter 3Health News:AxoGen, Inc. Reports 58% Year-Over-Year Revenue Growth for the 2015 First Quarter 4Health News:Hepatitis B Foundation Marks 50th Anniversary of HBV Discovery at its Crystal Ball Gala 2Health News:Hepatitis B Foundation Marks 50th Anniversary of HBV Discovery at its Crystal Ball Gala 3Health News:Baptist Medical Center Jacksonville Receives National Cancer Reaccreditation 2Health News:Baptist Medical Center Jacksonville Receives National Cancer Reaccreditation 3Health News:Baptist Medical Center Jacksonville Receives National Cancer Reaccreditation 4Health News:A Platform to Plan the Perfect Vacation was Featured on NewsWatch Television 2Health News:ProTexting SMS Mobile Marketing platform integrates with Constant Contact 2Health News:ProTexting SMS Mobile Marketing platform integrates with Constant Contact 3
... found twice the success rate when parents took part in ... play a significant role in the treatment of teens with ... involved in a treatment program, the percentage of teens able ... months doubled. , "Families have often been seen as part ...
... Signalife, Inc. (Amex:,SGN) has committed to deploy Fidelity 100 ... for testing of sudden cardiac death and,cardiovascular disease, events ... Profit Foundation ("AFL"), through mobile centers though which AFL,will ... its founders and,members some of the world,s greatest living ...
... Doctors and Patients More Precisely Stage, Diagnose ... and Treat ... (LCA), the only US-based organization devoted exclusively to,patient support and advocacy ... presentation by lead investigators of the,International Association for the Study of ...
... Mutual Life,Insurance Company (MassMutual) today announced the ... president of Corporate Human Resources. The,announcement was ... president and,chief administrative officer of MassMutual and ... LLC. Palermino, 54, joined MassMutual in ...
... part in therapy , , TUESDAY, Sept. 4 (HealthDay News) -- ... teens with bulimia, a new study has found. , When ... teens able to abstain from the eating disorder,s binge-purge pattern ... as part of the problem, rather than part of the ...
... patients with depression who are treated by primary care ... according to a new RAND Corporation study. , Physicians ... of the 20 measures of quality that researchers examined ... of the treatment recommendations studied, according to the report ...
Cached Medicine News:Health News:Parental Involvement Key to Battling Bulimia 2Health News:Parental Involvement Key to Battling Bulimia 3Health News:Signalife to Deploy Fidelity 100 Heart Monitors for AFL 2Health News:Signalife to Deploy Fidelity 100 Heart Monitors for AFL 3Health News:LCA Hails International Investigators Studying Lung Cancer 2Health News:MassMutual Promotes Debra Palermino to Senior Vice President of Human Resources 2Health News:Parental Involvement Key to Battling Bulima 2Health News:Parental Involvement Key to Battling Bulima 3Health News:Study finds primary care depression treatment often does not follow quality guidelines 2Health News:Study finds primary care depression treatment often does not follow quality guidelines 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: