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FIRMAGON® Results in Fast, Long-Term Suppression of Testosterone in Prostate Cancer Patients Without Initial Testosterone Surge
Date:6/1/2010

N®  that is devoid of surges, microsurges and has fewer testosterone escapes vs. leuprolide, represents a stride forward in the treatment of advanced prostate cancer and may affect outcomes," said Dr. Morote.

Presentation Highlights

Dr. Moul discussed the rationale for androgen deprivation therapy in prostate cancer, in that testosterone is essential for the growth and viability of prostate tumor cells.

Medical castration results in clinically meaningful benefits for men with differing states of prostate cancer.(1) GnRH agonists are a form of medical castration.  However, GnRH agonists initially cause testosterone surge that may last up to two weeks, may stimulate cancer growth, and may cause clinical flare in up to 63% of patients.(2) Testosterone reductions to castrate levels may take up to 30 days with GnRH agonists. Microsurges and testosterone breakthroughs may also result from LHRH agonist treatment.

Dr. Moul cited FIRMAGON® as an alternative and innovative approach for the treatment of advanced prostate cancer. FIRMAGON®  is an injectable gonadotropin-releasing hormone (GnRH) receptor antagonist approved for the treatment of advanced prostate cancer.  FIRMAGON reversibly binds to the GnRH receptors in the pituitary gland, immediately suppressing the secretion of the luteinizing hormone (LH), follicle-stimulating hormone (FSH), and subsequently, testosterone levels.(3-6) It causes more rapid medical castration and eliminates testosterone surge and microsurges without affecting the androgen receptor.  Unlike LHRH agonists, such as leuprolide, an established treatment for advanced prostate cancer, FIRMAGON® does not induce an initial testosterone surge.

Dr. Moul referenced a randomized Phase III pivotal trial of 610 prostate cancer patients, in which FI
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SOURCE Ferring Pharmaceuticals Inc.
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