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FIRMAGON® Results in Fast, Long-Term Suppression of Testosterone in Prostate Cancer Patients Without Initial Testosterone Surge
Date:6/1/2010

SAN FRANCISCO, June 1 /PRNewswire/ -- FIRMAGON® (degarelix for injection) resulted in fast, long-term suppression of testosterone in prostate cancer patients, without an initial testosterone surge or microsurge, and rapidly reduced prostate-specific antigen (PSA) levels, according to a review of data presented here today at the AUA 2010 annual meeting by Dr. Judd Moul, Chief of the Division of Urology at Duke University Health Science Center.

Dr. Moul was joined at the symposia by Dr. Juan Morote, of the Department of Urology, Vall d'Hebron Hospital and Autonoma University of Barcelona School of Medicine in Spain. Dr. Morote presented a retrospective analysis demonstrating testosterone escapes higher than castration levels for patients being treated with a GnRH agonist. The analysis also suggested a direct relationship between testosterone increases and androgen-independent progression, and that ineffective testosterone suppression therapy may result in higher prostate cancer mortality.  Both presentations were sponsored by Ferring Pharmaceuticals Inc.

"Use of a GnRH receptor antagonist is a highly efficient way to rapidly halt the production of testosterone," said Dr. Moul.  FIRMAGON® is an effective alternative treatment for hormonally sensitive advanced prostate cancer, and reduces testosterone to castrate levels at day 3 of treatment.  It immediately inhibits GnRH receptors on the pituitary gland, inducing rapid reduction of testosterone to castrate levels and sustaining those levels over time, which are the goals of systemic prostate cancer therapy."

"The use of an Androgen Deprivation Therapy (ADT) like FIRMAGO
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SOURCE Ferring Pharmaceuticals Inc.
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