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FDA Approves Lamictal®XR™ (Lamotrigine) for Conversion to Monotherapy for Treatment of Partial Seizures in Appropriate Patients
Date:4/25/2011

proved for use in children less than 13 years old.

The risk of getting a rash is higher if patients take Lamictal XR while taking valproate [Depakene* (valproic acid) or Depakote* (divalproex sodium)], take a higher starting dose of Lamictal XR than their healthcare provider prescribed, or increase their dose of Lamictal XR faster than prescribed.

LamictalXR can also cause other types of allergic reactions or serious problems which may affect organs and other parts of the body like the liver or blood cells. Patients may or may not have a rash with these types of reactions.Patients should call their healthcare provider right away if they have any of the following: a skin rash, hives, fever, swollen lymph glands, painful sores in the mouth or around the eyes, swelling of the lips or tongue, yellowing of the skin or eyes, unusual bruising or bleeding, severe fatigue or weakness, severe muscle pain, or frequent infections. These symptoms may be the first signs of a serious reaction. A healthcare provider should examine patients to decide if they should continue taking Lamictal XR.

LamictalXR may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Patients should call a healthcare provider right away if they have worsening depression, any unusual changes in mood or behavior, or thoughts or actions about suicide or self-harm, especially if they are new, worse, or worry the patient (see Medication Guide).LamictalXR may rarely cause aseptic meningitis, a serious inflammation of the protective membrane that covers the brain and spinal cord. Patients should call their healthcare provider right away if they have any of the following symptoms: headache, fever, nausea, vomiting, stiff neck, rash, unusual sensit
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SOURCE GlaxoSmithKline
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