Navigation Links
FDA Approves Ferriprox to Treat Patients with Excess Iron in the Body
Date:10/14/2011

SILVER SPRING, Md., Oct. 14, 2011 /PRNewswire-USNewswire/ -- The U.S. Food and Drug Administration today approved Ferriprox (deferiprone) to treat patients with iron overload due to blood transfusions in patients with thalassemia, a genetic blood disorder that causes anemia, who had an inadequate response to prior chelation therapy.

(Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO)

Patients with thalassemia have excess iron in the body from the frequent blood transfusions (transfusional iron overload), a condition that is serious and can be fatal.  These patients also have a risk of developing liver disease, diabetes, arthritis, heart failure or an abnormal heart rhythm.  

The standard of care to treat transfusional iron overload is chelation therapy – chemical agents that are used to remove heavy metals from the body. Ferriprox is intended for use when chelation therapy is inadequate.

"Ferriprox represents the first new FDA-approved treatment for this disorder since 2005," said Richard Pazdur, M.D., director of the Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research.

The safety and effectiveness of Ferriprox is based on an analysis of data from twelve clinical studies in 236 patients. Patients participating in the study did not respond to prior iron chelation therapy.  Ferriprox was considered a successful treatment for patients who experienced at least a 20 percent decrease in serum ferritin, a protein that stores iron in the body for later use. Half of the patients in the study experienced at least a 20 percent decrease in ferritin levels.

The most common side effects seen in patients who received Ferriprox included nausea, vomiting, abdominal and joint pain, urine discoloration (chromaturia), a decrease in the number of white blood cells (neutropenia), and an increase in
'/>"/>

SOURCE U.S. Food and Drug Administration
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. FDA Approves Lillys Osteoporosis Drug EVISTA(R) (raloxifene HCl) to Reduce The Risk of Invasive Breast Cancer in Two Populations of Postmenopausal Women
2. Health Canada Approves ATRIPLA(R) (efavirenz 600 mg/emtricitabine 200 mg/ tenofovir disoproxil fumarate 300 mg), the First Once-Daily Single Tablet Regimen for HIV
3. FDA Approves Cymbalta(R) for Maintenance Treatment of Major Depressive Disorder
4. European Commission Approves ATRIPLA(R) (efavirenz 600 mg/emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg), the First Once-Daily Single Tablet Regimen for Virologically Suppressed Adults With HIV-1 Infection
5. FDA Approves MiddleBrooks Amoxicillin PULSYS for Pharyngitis/Tonsillitis in Adolescents and Adults
6. FDA Approves XYZAL(R) (levocetirizine dihydrochloride) Oral Solution for the Relief of Seasonal and Year Round Allergies and Chronic Idiopathic Urticaria
7. UM Maryland Industrial Partnerships Program Approves 18 Collaborative Research Projects, Worth $4.4 Million, Between University Faculty, State Technology Companies
8. U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) for the Acute Treatment of Manic and Mixed Episodes Associated With Bipolar I Disorder in Pediatric Patients (10 to 17 Years of Age)
9. U.S. Food and Drug Administration Approves ORENCIA(R) (abatacept) for the Treatment of Moderate-to-Severe Polyarticular Juvenile Idiopathic Arthritis (JIA) in Patients Six Years and Older
10. FDA Approves HIFU Clinical Trial for Recurrent Prostate Cancer
11. EPA Approves XDS-CALUX(R) as Alternate Dioxin Test Method 4435
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... , July 31, 2014  Decision ... changes brought about by the Affordable Care ... and prescribing of pharmaceutical therapies. The ACA ... beneficiaries through new regulations and expanded access ... in the health exchanges—state-based marketplaces set up ...
(Date:7/31/2014)... -- Decision Resources Group is launching an extension of its ... include ChinaTrack; the new capabilities track the ... providing detailed brand-level share tracking and analytics. ChinaTrack also ... Other key capabilities of the new line extension: ... end-user surveys of healthcare facilities, ChinaTrack data is paired ...
(Date:7/31/2014)... , July 31, 2014  A substantial ... make decisions about which therapies are included in ... placement, according to a new Manhattan Research study, ... . The study finds that P&T committee members ... benefits managers (PBMs) have set a high bar ...
Breaking Medicine Technology:Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 2Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 3Health Exchanges Drive Change In MCO Strategies And Physician Prescribing Decisions; Impact On Pharma Mixed 4Decision Resources Group Announces First Medical Device Account Targeting Tool in China 2Formulary Decision Makers Say Pharma-Provided Patient Support Solutions Influence Formulary Placement 2Formulary Decision Makers Say Pharma-Provided Patient Support Solutions Influence Formulary Placement 3
... Helix Health, the first U.S.,stand-alone genomic medicine practice, is ... 1:00-2:30 PM EDT examining:, How Genomic Medicine ... To register, point your browser here, http://event.netbriefings.com/event/helixhealth/register.html ... States are diagnosed with cancer.,There is a growing number ...
... Scientists Refused To Do,Illustrates Vaccine Program And Mercury ... Findings released Friday,showed that infant monkeys given ... Academy of Pediatrics (AAP) exhibited autism-like,symptoms. Lead investigator ... presented study results at the International Meeting for,Autism ...
Cached Medicine Technology:Join NPR's David Ewing Duncan, Author Jessica Queller and a Panel of Medical and Legal Experts in a 90-Minute Webcast on Genetic Testing, Genomic Medicine and Breast & Ovarian Cancer 2Infant Vaccines Produce Autism Symptoms in New Primate Study by University of Pittsburgh Scientists 2
(Date:7/31/2014)... An All Star Comedy Night will take ... to raise funds for Avery Moskowitz who has Neuroblastoma, a ... Marie Thompson from Lindenhurst both have multiple ties to Avery ... fundraiser and worked hard at securing sponsors. Avery's story ... on Facebook , Atlantic Toyota and NY ...
(Date:7/31/2014)... 2014 In a front-page story, the ... Johnson & Johnson, is withdrawing its laparoscopic power morcellator ... cancer. This important story has also been reported ... the AP (7/30), the Pittsburgh Business Times (7/30) and ... during uterine procedures to, “slice up common uterine masses ...
(Date:7/31/2014)... Albany, New York (PRWEB) July 31, 2014 ... U.S. is a major factor driving the global geriatric ... the demand outstrips the supply of these services across ... a family forming a home care agency to few ... implies that the market is underserved and is also ...
(Date:7/31/2014)... news in the study of happiness. , Rest ... of Cincinnati research on perceived happiness shows that many ... This is despite the fact that there are simple ... says Keith King, professor and coordinator of UC,s Health ... use them enough. , "We have a whole array ...
(Date:7/31/2014)... Parenting skills of adults with ADHD improve when ... Penn State College of Medicine researchers., At least ... disorder have a parent with ADHD. , "Parents ... in problematic parenting techniques, including inconsistent disciplinary practices, ... said James Waxmonsky, associate professor of psychiatry. "Having ...
Breaking Medicine News(10 mins):Health News:Local Long Island Massage Day Spa and Auto Dealer Combine Forces to Raise Funds for 4 Year Old Who Has Cancer 2Health News:Local Long Island Massage Day Spa and Auto Dealer Combine Forces to Raise Funds for 4 Year Old Who Has Cancer 3Health News:Have You Had a Hysterectomy or Removal of Uterine Fibroids? Morcellator Device Withdrawn From Market Due To Cancer Risk 2Health News:Have You Had a Hysterectomy or Removal of Uterine Fibroids? Morcellator Device Withdrawn From Market Due To Cancer Risk 3Health News:Geriatric Care Services Market (Home Care, Adult Day Care, and Institutional Care): Global Industry Analysis, Size, Share, Growth, Forecast 2013 - 2019 2Health News:Geriatric Care Services Market (Home Care, Adult Day Care, and Institutional Care): Global Industry Analysis, Size, Share, Growth, Forecast 2013 - 2019 3Health News:Geriatric Care Services Market (Home Care, Adult Day Care, and Institutional Care): Global Industry Analysis, Size, Share, Growth, Forecast 2013 - 2019 4Health News:Geriatric Care Services Market (Home Care, Adult Day Care, and Institutional Care): Global Industry Analysis, Size, Share, Growth, Forecast 2013 - 2019 5Health News:Simple tips to fend off freak-outs 2Health News:Simple tips to fend off freak-outs 3Health News:Parenting skills improve in ADHD parents with medication 2
... yoga guru Baba Ramdev, yoga when practiced regularly can ward ... thinking//. He also added that yoga not only cure but ... is just one reason behind the increasing number of cancer ... the disease," said Ramdev, who was recently in Ratlam district ...
... at work do not shoot up blood pressure, say scientists, ... ,Samuel J. Mann, professor of clinical medicine at Weill ... the subject and found that the evidence that workplace stress ... and very inconsistent, reported Newswise. ,"When you realise ...
... a separate insurance scheme as they would no longer be ... that they can go without insurance to save money which ... with a serious medical problem. Even those who find ... months since there's often a waiting period before employer-sponsored coverage ...
... star died in a freak accident, after he was dragged to ... after stealing Koster’s car. , ,Koster had beseeched the ... rob his car, as per police reports. Apparently the car was ... , ,Witnesses informed the police that they saw Dowds driving ...
... have been able to observe how an embryonic retina cell develops ... assigned to it.// Scientists were able to catch the cell when ... begun shaping up to do it. , ,The study also ... This particular substance was known to be vital for the development ...
... Investigations by the U.S. Department of Justice has ... Atascadero are besetted with widespread problems, including inadequate ... prolonged hospitalization. ,In addition violence among ... inadequate care that has led to visible signs ...
Cached Medicine News:Health News:Insurance Plans after Graduation 2Health News:The ABC Of Photoreceptors In The Eye 2Health News:Mental Hospitals Offer More Problems than Solutions 2
... (TSH) is a 32 kDa glycoprotein secreted ... pituitary gland [1]. The structure of human ... pituitary and placental gonadotropins, consisting of an ... these hormones and a unique beta-subunit, which ...
... (T4) is the primary active hormone synthesized ... gland [1]. T4 is synthesized via a ... by the follicular cells, (ii) iodination of ... to formation of 3-monoiodotyrosine and 3,5-diiodotyrosine (MIT ...
... produced primarily by 5-monodeioination of thyroxine (T4) ... T3 production occurs at a rate which ... Release of T3 from the thyroid gland ... compared to 80-100 micrograms/day for T4. In ...
... protein-3 (IGFBP-3) is the main binding protein for ... component of the ~150 kDa ternary complex. This ... or IGF-II and ALS, allowing IGFBP-3, along with ... The molar concentration of IGFBP-3 in normal serum ...
Medicine Products: