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FDA Approves Elitek(R) (rasburicase) for Management of Plasma Uric Acid Levels in Adults with Leukemia, Lymphoma, and Solid Tumors Receiving Anti-Cancer Therapy
Date:10/16/2009

rome (TLS) is a metabolic complication that can result either spontaneously or following treatment of certain types of rapidly-growing cancers, particularly leukemia or lymphoma. The syndrome develops when a particularly large volume of tumor cells are rapidly destroyed by treatment, releasing their contents - including nucleic acids, which are then eventually catabolized into uric acid - into the bloodstream. Elevated levels of plasma uric acid (hyperuricemia) is a serious condition that can lead to kidney impairment if not controlled. Prevalence of TLS varies among patients with different types of cancer, but occurs more often with malignancies that are particularly sensitive to anti-cancer therapy.

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