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FDA Accepts Investigational New Drug Application for ARI-3030MO; First in Man Clinical Trial to Begin During First Quarter of 2011
Date:3/21/2011

acy and/or tolerability benefits compared with existing therapies for large markets, whose needs are not being fully met by current therapeutics.  

About Niacin Analog Program

The natural B vitamin niacin is a well known lipid lowering agent and has been used to treat mixed lipid disorders for over 50 years.  Niacin is recommended as a first-line drug for the treatment of hyperlipidemia and it is used in combination with statins to further reduce LDL cholesterol or to increase HDL cholesterol in patients with depressed HDL cholesterol levels.  Niacin can produce changes in HDL cholesterol up to 35%, lower LDL cholesterol up to 25% and lower triglycerides up to 50%.  Despite niacin's broad lipid altering profile, the use of niacin based therapies is diminished because of unpleasant side effects, particularly flushing.  Flushing, representative of tingling and/or redness of the skin, is the principal side effect of niacin and in some patients can be extremely uncomfortable.  Arisaph has developed a novel and proprietary class of structural analogs of niacin that produce compelling changes in lipids without provoking flushing as shown in preclinical pharmacology studies.

Certain statements in this press release, including statements regarding the Company's research and development effort, the Company's expectation to initiate human clinical studies, the Company's ability to finance its development programs into human clinical testing, and the Company's ability to successfully capitalize on the early stage research are subject to risks and uncertainties, which could cause the Company's actual results and the timing of certain events to differ materially from the Company's expectations. These risks and uncertainties include risks and uncertainties related to:  our ability to discover and develop new compounds and products using a novel approach to drug discovery; the early stage of all of ou
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SOURCE Arisaph Pharmaceuticals, Inc.
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