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FDA Accepts Investigational New Drug Application for ARI-3030MO; First in Man Clinical Trial to Begin During First Quarter of 2011
Date:3/21/2011

ical observations in 28-day rat and dog toxicological studies or in several other nonclinical studies, in which ARI-3037MO was administered in various doses to multiple species.  Flushing, representative of tingling and/or redness of the skin, is the principal side effect of niacin and in some patients can be extremely uncomfortable.  Consequently, many patients fail to achieve efficacious dosing or discontinue niacin therapy altogether, resulting in poor patient compliance and adherence.(2,3)  Based on preclinical results, the Company believes that ARI-3037MO represents an advancement in treating mixed lipid disorders in patients with coronary heart disease.

About Arisaph

Arisaph Pharmaceuticals Inc, an emerging biopharmaceutical company located in Boston, Massachusetts, was founded by Dr. William Bachovchin (Professor of Biochemistry, Tufts University School of Medicine), Christopher Kiritsy (Former EVP Corporate Development and CFO Kos Pharmaceuticals, Inc.) and Michael Jaharis (Founder, Chairman Emeritus, Kos Pharmaceuticals, Inc.) to develop differentiated therapies for cardiometabolic diseases and cancer.  Arisaph employs rational drug design approaches to develop differentiated new chemical entities (NCEs) that are highly potent and act on select, validated targets. By focusing its drug development activities on validated targets, the Company believes that the risks associated with new chemical entity development can be mitigated compared with developing first-in-class compounds for nonvalidated targets.  Arisaph has developed a rich pipeline of products at various stages of preclinical development, including a tumor activated prodrug platform being developed for both liquid and solid tumors.  The Company's vision is to create a fully integrated pharmaceutical company leveraging its drug discovery expertise to develop transformational, patent protected, medicines that offer distinct safety, effic
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SOURCE Arisaph Pharmaceuticals, Inc.
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