Navigation Links
FDA Accepts Investigational New Drug Application for ARI-3030MO; First in Man Clinical Trial to Begin During First Quarter of 2011
Date:3/21/2011

ose limited because of adverse side effects, such as gastrointestinal intolerance, liver enzyme elevations and flushing. The Company believes that ARI-3037MO can produce greater therapeutic benefits than existing forms of niacin as a result of mitigating such adverse side effects.  

In preclinical studies involving hamsters fed a high-fat diet, ARI-3037MO showed robust changes in lipids, including LDL and HDL cholesterols and triglycerides (TGs).  Specifically, once-daily treatments of ARI-3037MO lowered both LDL cholesterol and TGs greater than 70% from placebo.  In comparison, higher doses of niacin reduced LDL cholesterol and TGs approximately 50% from placebo.  Additionally, ARI-3037MO increased the proportion of HDL cholesterol to a greater extent than niacin.  ARI-3037MO treated hamsters showed a significant increase in ATP-binding cassette transporter A1 (ABCA1), apolipoprotein A-1 (ApoA1), and adiponectin compared to the vehicle control animals.  The ABCA1 and ApoAI increases are noteworthy, as the proteins that result from these transcripts are involved in the synthesis and maturation of HDL.  

"Significant lipid changes coupled with the increased mRNA levels for certain regulatory proteins involved in HDL synthesis and reverse cholesterol transport offers compelling evidence to support the mechanism based efficacy of this niacin analog," commented, Dr. Ernst Schaefer, Professor of Medicine, Tufts University School of Medicine. "The availability of an effective and tolerable niacin replacement would be a major advancement for the treatment of mixed lipid disorders."

In addition to the compelling preclinical efficacy, ARI-3037MO did not induce "flushing" as measured by changes in capillary blood flow via the ear in mice. Such capillary blood flow measurements have translated well in evaluating the effects of niacin on flushing in human clinical trials. Additionally, flushing was not observed during clin
'/>"/>

SOURCE Arisaph Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. NYSE Amex Accepts China Shenghuos Compliance Plan for Continued Listing
2. The European Medicines Agency Validates and Accepts Cell Therapeutics Marketing Authorization Application for Pixuvri™
3. The SCOOTER Store Accepts Medicare Contracts
4. FDA Accepts Aricept® Patch (Donepezil Transdermal System) NDA for Review
5. FDA Accepts Sanofi Pasteur File Submission for Novel Influenza Vaccine Delivered by Intradermal Microinjection
6. FDA Accepts Sanofi Pasteurs Application to Expand Indication of Menactra® Vaccine to Infants and Toddlers
7. Talecris Biotherapeutics CEO Accepts 2010 Ernst & Young Entrepreneur Of The Year Award on Behalf of Employees and Patients
8. FDA Accepts Once Daily 23 mg Aricept(R) Extended Release NDA for Review
9. FDA Accepts sNDA for Alternative Dosing Regimen for Dacogen(R) (decitabine for injection) to Treat Patients with Myelodysplastic Syndromes (MDS)
10. FDA Accepts Arno Therapeutics IND for AR-12 a PDK1 Inhibitor That Blocks the PI3K/Akt Pathway
11. Food and Drug Administration Accepts Isolagens Biologics License Application for Full Review
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... , Jan. 15, 2014  Novation, the leading health care ... new IT value-added reseller (VAR) national contracts that expand ... and services at lower costs. These include manufacturer product ... as initiative assistance and ongoing IT consulting support. ...
(Date:1/15/2014)... BreedIT Corp (OTC: BRDT), through its Israeli ... sophisticated agro-breeding solutions for plant breeders and researchers, today ... of directors appointed chemistry and pharmaceutical industry expert Dr. ... the board. From 1975 to 2012, Dr. ...
(Date:1/15/2014)... Jan. 15, 2014  Echo Therapeutics, Inc. (Nasdaq: ... Symphony® CGM System as a non-invasive, wireless continuous glucose ... , Executive Chairman and Interim CEO of Echo Therapeutics, ... Annual Equity Conference. Mr. Doman will ...
Breaking Medicine Technology:New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3
... BOSTON, Jan. 27, 2011 Solos Endoscopy, Inc. (OTCPK: SNDY) ... the three months ended December 31, 2010 in the amount ... a result of instrument sales to over fifty Hospitals, Clinics, ... States. Solos looks towards continued growth in 2011 ...
... /PRNewswire-Asia/ -- Weikang Bio-Technology Group Co., Inc. ... the "Company"), a leading developer, manufacturer and marketer of ... and other health and nutritional products in the People,s ... products, Ranitidine Hydrochloride Capsule, has been added to the ...
Cached Medicine Technology:Solos Endoscopy, Inc. Reports $90,005 in Sales Revenue for Fourth Quarter 2010 2Weikang Bio-Technology Announces Inclusion of Ranitidine Hydrochloride Capsule on National Drug Reimbursement List 2Weikang Bio-Technology Announces Inclusion of Ranitidine Hydrochloride Capsule on National Drug Reimbursement List 3
(Date:7/9/2014)... a relatively optimistic picture of women,s chances of surviving ... the chest wall or skin, but not beyond. ... size and whether they have involved lymph nodes, are ... advanced" tumors, suggesting that they are a relatively serious ... breast cancers of this and other types account for ...
(Date:7/9/2014)... This news release is available in French . ... different factors in 14 year old teens, including brain structure ... with 70% accuracy who will go on to develop binge ... lack of conscientiousness, and other variables such as life events ... likelihood of binge drinking. Whether or not the child ...
(Date:7/9/2014)... have a reputation for being highly toxic, but when used ... being found to offer potential health benefits in a range ... A new compound (AP39), designed and made at the University ... targeting delivery of very small amounts of the substance to ... in Exeter have already found that the compound protects mitochondria ...
(Date:7/9/2014)... age with kidney and heart disease have raised concerns ... adults. However, in the first study to look closely ... Medicine at the University of Pennsylvania report that older ... expectancy and cardiovascular health as very healthy older people ... the ever increasing organ transplant waitlists, the authors of ...
(Date:7/8/2014)... and cardiovascular health as other healthy mature individuals, according ... Journal of Transplantation . The findings may provide some ... professionals caring for them. , Over the past two ... and older has become more common. Given the links ... removal of a kidney could make older donors vulnerable ...
Breaking Medicine News(10 mins):Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 3Health News:What drives a child to abuse alcohol? 2Health News:Rotten egg gas holds key to healthcare therapies 2Health News:Penn study finds living kidney donation does not increase risk of death or heart disease for older 2Health News:Study finds kidney donation safe for healthy older adults 2
... In this season of giving and sharing, St.,David,s Community ... $5.15 million in grants to area nonprofit organizations that ... "Especially this year, we ... care for Central Texans," said Earl Maxwell, CEO of ...
... Dec. 16 Globus Medical, Inc., the largest privately ... the appointment of Wendy DiCicco, CPA, as Chief Financial ... of a publicly traded medical device manufacturer to the ... she was the CFO for Kensey Nash Corporation (Nasdaq: ...
... 16 SunTrust Banks, Inc.,(NYSE: STI ... for employers seeking to take control of their ... administrative and financial,components, including a healthcare payment card, ... options, offered,through a single trusted custodial partner. , ...
... January 2009 issue, The Journal of Nuclear Medicine ... , "This change to the publication allows the ... structure and organization of research reports," said Heinrich R. ... of Nuclear Medicine . "Most important and critical, it ...
... The Body By Milk campaign -- famous for,putting white ... up with the,five-time GRAMMY(R)-Award winning and multi-platinum selling artist, Usher, ... the Body By,Milk got noise? music video program. , ... give 20 lucky teens the chance to flex their,creative muscle ...
... 16 December 2008 - The effectiveness of voriconazole in ... study to be featured in the International Journal ... Elsevier. Fungal infections can kill people with weakened immune ... or organ replacement, and the research reinforces earlier findings ...
Cached Medicine News:Health News:$5.15 Million Provided to Support Local Health Care Needs 2Health News:$5.15 Million Provided to Support Local Health Care Needs 3Health News:$5.15 Million Provided to Support Local Health Care Needs 4Health News:Globus Medical Strengthens Executive Team with Appointment of CFO 2Health News:SunTrust Introduces Health Savings Accounts for Employers Seeking to Take Control of Healthcare Costs 2Health News:SunTrust Introduces Health Savings Accounts for Employers Seeking to Take Control of Healthcare Costs 3Health News:Journal of Nuclear Medicine premiers new, full-color design 2Health News:Usher Teams With Body By Milk to Give Teens Once-in-a-Lifetime Opportunity 2Health News:Usher Teams With Body By Milk to Give Teens Once-in-a-Lifetime Opportunity 3Health News:Voriconazole: A highly potent treatment for fungal infections 2
... nebulizer achieves optimum lung penetration for maximum ... is 1.04-1.10 µ at 6-8 LPM. Latex-free ... ,As the world leader in airway ... assurance of proven technology by offering top ...
... OMNI~NEB delivers breakthrough continuous low-flow nebulizer ... precise nozzle technology allows for optimal ... or without Heliox). OMNI~NEB takes on ... both routine and critical care situations. ...
... a spill-proof design and effective output, even ... All medical nebulizers are free-standing for easy ... are available., ,All Portex® medication nebulizer ... nebulizers feature consistently fine misting and the ...
... Portex® medication nebulizers offer a spill-proof ... up to a 45° angle. All medical ... ,A wide variety of configurations are available., ... latex-free. , ,Portex® medication nebulizers feature ...
Medicine Products: