Navigation Links
FDA Accepts Investigational New Drug Application for ARI-2243 and a First in Man Clinical Trial Set to Begin During the First Half of 2008
Date:3/11/2008

-- ARI-2243 is a highly potent DPP-4 inhibitor being developed for the

treatment of Type II diabetes -- ARI-2243 produced a compelling 2.5% reduction in HbA1c in refractory

diabetic animal model

-- ARI-2243 is a first-in-class "soft drug" conferring functional

selectivity -- Nonclinical toxicology evaluation shows ARI-2243 has high therapeutic

index

BOSTON, March 11 /PRNewswire/ -- Arisaph Pharmaceuticals, Inc., a privately held drug discovery biopharmaceutical company, today announced that the U.S. Food and Drug Administration (FDA) has accepted the company's recently submitted Investigational New Drug (IND) application to evaluate ARI-2243 in a phase I clinical trial in healthy volunteers. ARI-2243 is a highly potent DPP-4 inhibitor, possessing superior preclinical efficacy and a high therapeutic index established in nonclinical toxicology testing. In addition to significant potency for inhibiting the DPP-4 enzyme, ARI-2243 possesses a first-in-class "soft drug" feature by which the compound becomes inactive when unbound to the target enzyme, thereby contributing to improvements in safety. Arisaph expects to initiate a first-in-man clinical trial during the first half of 2008 and is developing the product for the treatment of Type II diabetes, which afflicts about 20 million people in the United States and in excess of 170 million people worldwide.(1,2)

"The FDA's acceptance of our IND marks an important milestone for the company," said Christopher P. Kiritsy, President and Chief Executive Officer of Arisaph Pharmaceuticals. "With ARI-2243, we are making progress towards our goal of developing best-in-class medicines for validated targets. We believe ARI-2243 has the potential to not only exhibit a superior efficacy profile but also show a favorable safety profile by means of the unique "soft drug" feature that
'/>"/>

SOURCE Arisaph Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. FDA Accepts Wyeths Supplemental New Drug Application for Tygacil for the Treatment of Patients with Community-Acquired Pneumonia
2. Solvay Pharmaceuticals, Inc. and Wyeth Pharmaceuticals Announce Receipt of an FDA Action Letter for Bifeprunox, an Investigational Treatment for Schizophrenia
3. A Worldwide Phase III Clinical Trial Seeks U.S. Patients to Explore Investigational Drug Phenoxodiol
4. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
5. ECLIPSE Data on Effects of Otsukas Investigational Novel Treatment, Tolvaptan, on Advanced Heart Failure Patients Hemodynamics and Urine Output Featured in Heart Failure Society of Americas Late Breaking Trials
6. Replidynes Investigational Antibacterial Agent REP3123 Prevents Sporulation in Clostridium difficile
7. Replidynes Investigational Antibacterial Agent REP3123 Prevents Toxin Production in Clostridium difficile
8. Wyeth Presents Phase 3 Fracture Data for Bazedoxifene, an Investigational Therapy for Osteoporosis
9. Newly Published Phase II Study Shows the Investigational Drug Vandetanib Prolongs Progression-Free Survival in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)
10. KineMed Presents Preclinical Data for Investigational Agent Demonstrating Neurogenesis and Confirming Improvements in Behavioral Model
11. Lexicon Reports Initial Clinical Trial Results for LX1031, an Investigational New Drug for Irritable Bowel Syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... 10, 2014   Ventana Medical Systems, Inc.  (Ventana), ... has entered into an agreement with Merck KGaA, Darmstadt, ... Serono in the United States ... Merck KGaA,s biopharmaceutical division on the development and commercialization ... using Ventana,s proprietary diagnostic assays. In alignment with Merck ...
(Date:7/10/2014)... 10, 2014 CVS Caremark Corporation (NYSE: ... approved a quarterly dividend of $0.275 (27.5 cents) per share ... August 1, 2014, to holders of record on July 21, ... Caremark is dedicated to helping people on their path to ... the United States . Through the company,s more ...
(Date:1/15/2014)... 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com adds "China Orthopedic Instrument Industry ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) Benefiting ... China,s orthopedic instrument industry has ... size rising from 3.28 billion yuan in 2006 to ...
Breaking Medicine Technology:Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3
... Sunpeaks Ventures, Inc. (OTCBB: SNPK) (PINKSHEETS: SNPK) (the ... Healthcare Distribution Specialist, LLC ("HDS") are pleased to announce ... Vitamin & Sports Nutrition Expo to be held at ... Florida on July 15-17, 2012.  As part of the ...
... announced today the Clinical Laboratory Responsibility Pledge, a ... ethical business practices in the medication monitoring industry. ... adheres and to which the company challenges every ... adopt. (Logo: http://photos.prnewswire.com/prnh/20120203/LA47138LOGO ) ...
Cached Medicine Technology:Sunpeaks Ventures to Participate in ECRM Conference and Expo 2Sunpeaks Ventures to Participate in ECRM Conference and Expo 3Millennium Laboratories Announces Laboratory Responsibility Pledge 2Millennium Laboratories Announces Laboratory Responsibility Pledge 3
(Date:7/13/2014)... inexpensive, portable, microchip-based test for diagnosing type-1 diabetes ... better understand the disease, according to the device,s ... , Described in a paper to be published ... the test employs nanotechnology to detect type-1 diabetes ... the two main forms of diabetes mellitus, which ...
(Date:7/13/2014)... Recently, MillionaireCasket.com, a well-known casket manufacturer from China, has ... the company’s chief executive officer has announced a new promotion ... offered at discounted prices, from 15 to 26 percent off. ... in huge demand in the current market. We are excited ... a lot of high quality products for sale. Many of ...
(Date:7/13/2014)... The North American water storage systems market is estimated ... by 2018, at a CAGR of 21.0%, from 2013 to ... rapid pace in North America. The U.S. is experiencing high ... wastewater storage and collection, and the increased spending on modernization ... a healthy rate in Canada, and is rising at a ...
(Date:7/13/2014)... 13, 2014 The report “Micronutrient ... Iron), Form (Chelated & Non Chelated), Application Mode ... Global Trends and Forecast to 2018” defines and ... analysis and forecasting of the global value and ... driving and restraining factors for the global agriculture ...
(Date:7/13/2014)... Fuel additives are chemicals, which are ... fuel, kerosene, and so on, in order to enhance ... the corrosion effects caused by fuels and improving the ... fuel, provide economies of scale in the long run, ... cost of the fuel products. , The various fuel ...
Breaking Medicine News(10 mins):Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 2Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 3Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 4Health News:Cheap Oak Caskets Recently Unveiled By China Casket Manufacturer MillionaireCasket.com 2Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 2Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 3Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 2Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 3Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 4Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 4
... residues in their milk. But antibiotics are sometimes used even ... hours to produce a result and do not test for ... closed, thanks to a fully automated minilab developed by scientists ... gwk Praezisionstechnik GmbH. Even at the best of ...
... investigations, researcher says , FRIDAY, May 7 (HealthDay News) -- ... variations in human eye color. , The researchers, led by ... link eye color in 6,000 Dutch people to their genetic ... sense -- blue, green, brown -- as in previous ...
... ... laundry detergent? In the spirit of Mother’s Day and as a gift to mothers (and fathers) ... applicable for babies as they are for brands. , ... (PRWEB) May 7, 2010 -- What does naming a baby have to do with ...
... ... had a family member or friend in a hospital knows just how stressful ... circle of friends and family. With the launch of a new iPhone tool ... right from your phone, instantly. You can choose who you want to communicate ...
... ... Free Baseball Tickets and More , ... Dublin, Ohio (PRWEB) -- Dynowatt, an independent provider of electricity and green power, ... game. When you “become a fan” of Dynowatt (powered by Accent Energy) on the ...
... ... preliminary shoots for the Pink Ribbon Connection’s annual breast cancer charity calendar. The calendar ... survivors of breast cancer. , ... Indianapolis, IN (PRWEB) May 6, 2010 -- Dario Infini saw a chance to give back ...
Cached Medicine News:Health News:Minilab can quickly identify antibiotic residues in milk, before it leaves the barn 2Health News:Minilab can quickly identify antibiotic residues in milk, before it leaves the barn 3Health News:Mother's Day Special: Catchword's 10 Rules for Branding Your Baby 2Health News:Mother's Day Special: Catchword's 10 Rules for Branding Your Baby 3Health News:Mother's Day Special: Catchword's 10 Rules for Branding Your Baby 4Health News:New "howsthepatient" iPhone App Provides a Simple, Seamless Way to Send Health Updates to Friends and Family 2Health News:New "howsthepatient" iPhone App Provides a Simple, Seamless Way to Send Health Updates to Friends and Family 3Health News:New "howsthepatient" iPhone App Provides a Simple, Seamless Way to Send Health Updates to Friends and Family 4Health News:Dynowatt Offers Facebook Fans a Chance to See the Rangers and Astros Play for Texas Bragging Rights 2Health News:Dynowatt Offers Facebook Fans a Chance to See the Rangers and Astros Play for Texas Bragging Rights 3Health News:Indiana Boudoir Photographer Begins Shooting Breast Cancer Charity Calendar 2
... therapeutic benefits of controlled compression to minimize ... pain. The cuff is anatomically designed to ... The Ankle Cryo/Cuff is one-size for adults ... size.,All Cryo/Cuffs can be ordered as a ...
SCD Sequential Compression System Intermittent Pneumatic Compression...
Comfor™ Cast Boot - Rocker Sole - Closed Toe...
... cast boot specially lasted for fiberglass ... rocker sole for easy ambulation! ,The ... narrow last so it fits better ... and with our stretchable upper, a ...
Medicine Products: