Navigation Links
FDA Accepts Arno Therapeutics' IND for AR-12 a PDK1 Inhibitor That Blocks the PI3K/Akt Pathway
Date:5/11/2009

PARSIPPANY, N.J., May 11 /PRNewswire-FirstCall/ -- Arno Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on oncology therapeutics, today announced that the U.S. Food and Drug Administration ("FDA") accepted the Company's Investigational New Drug ("IND") application for the use of AR-12, a potentially first-in-class, orally available, PDK1 inhibitor that blocks the PI3K/Akt pathway and induces the endoplasmic reticulum stress pathway. Acceptance of the IND permits Arno to initiate a Phase I clinical trial in adults with advanced or recurrent solid tumors or lymphoma for which no standard therapy is available. Arno expects the Phase I clinical trial to begin during the second half of 2009 and will be designed to assess the safety and early evidence of activity of AR-12.

"We are excited that AR-12 has received IND acceptance by the FDA allowing us to begin our Phase I studies. Our preclinical data has demonstrated that AR-12 is active in a wide range of tumor types and it also shows promising activity in combination with several widely used approved cytotoxic as well as molecularly targeted anti-cancer agents," stated Dr. Roger G. Berlin, Chief Executive Officer of Arno.

About AR-12

AR-12 is a potentially first-in-class, orally available, PDK1 inhibitor that blocks the PI3K/Akt pathway and induces the endoplasmic reticulum stress pathway.

About Arno Therapeutics

Arno Therapeutics, Inc. is a clinical-stage biopharmaceutical company that develops and commercializes innovative products for the treatment of cancer patients. Arno's lead clinical development compound is AR-67, a novel, third-generation camptothecin analogue which has completed patient enrollment of its Phase I studies in patients with advanced solid tumors, that has demonstrated high preclinical potency and improved pharmacokinetic properties when compared with marketed second-g
'/>"/>

SOURCE Arno Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Food and Drug Administration Accepts Isolagens Biologics License Application for Full Review
2. FDA Accepts Complete Response Submission to New Drug Application for NEBIDO(R)
3. European Regulatory Agency Accepts Cell Therapeutics, Inc.s Marketing Authorization Application for XYOTAX(TM) for Lung Cancer for Review
4. FDA Accepts Investigational New Drug Application for ARI-2243 and a First in Man Clinical Trial Set to Begin During the First Half of 2008
5. FDA Accepts Wyeths Supplemental New Drug Application for Tygacil for the Treatment of Patients with Community-Acquired Pneumonia
6. Logical Therapeutics Appoints Peter A. Lankau as CEO and Director
7. Arcion Therapeutics Topical Pain Candidate, ARC-4558, Significantly Reduces Pain Caused by Diabetic Neuropathy
8. Trius Therapeutics Announces Presentations Featuring Torezolid Antibiotic at the 19th European Congress of Clinical Microbiology and Infectious Diseases
9. Hyperion Therapeutics Receives Orphan Drug Designation for HPN-100 for the Treatment of Urea Cycle Disorders
10. Sirion Therapeutics Announces Clinical Data Presentations at the 2009 Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
11. Intarcia Therapeutics, Inc. Announces Completion of Enrollment of ITCA 650 Phase 1b Study for the Treatment of Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... 11, 2014 According to a ... Devices Market (Endoscopes, Endoscopic Operative Devices, and Visualization Systems) ... Forecast, 2013-2019" the global endoscopy devices market was valued ... to grow at a CAGR of 6.8% from 2013 ... 36.9 billion in 2019. Browse the full ...
(Date:7/11/2014)... 2014 Neurelis, Inc. ("Neurelis") today announced an ... option held by Biotie to purchase Neurelis, clearing the ... (intranasal diazepam) for pediatric and adult epilepsy patients who ... year, Biotie has advanced the development program for NRL-1 ... clinical work required for NDA submission to the FDA.  ...
(Date:7/10/2014)...  Breg, Inc., a premier provider of sports ... knee brace with new innovations to help people, ... to active lifestyles.  FreeRunner,s patent-pending design acts on ... when patients need it most, and the ability ... Patellofemoral issues are the most common cause of ...
Breaking Medicine Technology:Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2
... 2007 - Advanced Cell,Technology, Inc.'s (OTCBB: ACTC) ability ... Scientific American's March 2007 issue as the,lead story ... of the article,which notes Advanced Cell's ability to ... pigment epithelial (RPE),tissue," is timely as it comes ...
... Pa.--(BUSINESS WIRE)--Mar 7, 2007 - Gemin X,announced ... online version of,the journal Blood demonstrated that ... responses against,patient-derived multiple myeloma tumor cells as ... as a combination therapy.,GX15-070 is a small ...
Cached Medicine Technology:Advanced Cell Technology's Ability to Rescue Vision in Blind Rats,Noted in Scientific American 2Advanced Cell Technology's Ability to Rescue Vision in Blind Rats,Noted in Scientific American 3Gemin X Announces Publication of Preclinical Data of GX15-070 in,Multiple Myeloma in Blood 2
(Date:7/11/2014)... Recently, MagicQuinceaneraDresses.com, the popular online supplier ... of 2014 Quinceanera dresses . The company’s new ... look fashionable without paying a large amount of money. ... 57% off. , The company’s online shop has become ... special occasion outfits. In addition to exquisite Quinceanera dresses, ...
(Date:7/11/2014)... The American Association of Poison Control Centers ... commending Senator Bill Nelson (D-FL) for his introduction of ... July 10, 2014. Along with fellow Senate co-sponsors, this ... to enact rules requiring safer, child-resistant packaging for any ... co-sponsors of the bill include: Sen. Richard Blumenthal (D-CT), ...
(Date:7/11/2014)... Down reports that tickets to the Argentina vs. Germany ... between Brazil and Netherlands are in high demand. ... 12th at Estadio Nacional de Brasilia Mane Garrincha Brasila, Federal ... July 13th at Estadio Jornalista Mario Filho - Estadio do ... Cup are guaranteed to be authentic and are covered by ...
(Date:7/11/2014)... 11, 2014 Butler Mobility has recently updated ... Platform Lifts . Previously the two standard colors were ... beautiful earth tone colors as standard colors at no additional ... the home but will enhance the beauty of the stairway. ... home color scheme or individual décor. , The new selection ...
(Date:7/11/2014)... (HealthDay News) -- People with the lowest incomes may have ... disease (PAD), a new study suggests. People with PAD ... limbs, most often the legs. The condition causes leg pain ... throughout the body. People with PAD have a higher risk ... nearly 6,800 people with PAD who took part in the ...
Breaking Medicine News(10 mins):Health News:Cheap Quinceanera Dresses Now Available At MagicQuinceaneraDresses.com 2Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 2Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 3Health News:Argentina vs. Germany World Cup Finals Tickets & Brazil vs. Netherlands 3rd Place World Cup Tickets Are in Huge Demand 2Health News:Butler Mobility Products Announces Five New Standard Colors for Their Inclined Platform Lifts 2Health News:Poor More Prone to Leg Circulation Trouble 2
... HealthDay Reporter , THURSDAY, Feb. 24 (HealthDay News) -- A ... of the organ a day after birth, scientists report. ... that ways can be found to help the human heart ... heart for regeneration, but they,re somehow permanently switched off," said ...
... New findings by a University of Maryland-led team of ... for a human anti-malarial antibody or a scorpion ... environmentally friendly tool for combating malaria, at a time ... is declining. In a study published in the ...
... By Steven Reinberg HealthDay Reporter , THURSDAY, Feb. ... decades ago, they are still pervasive in the United States ... a new study suggests. In fact, PCBs may account ... after IVF, the researchers said. "These findings may help ...
... redesign of the nation,s donor-liver distribution network developed by ... more people each year receiving the transplants they need. ... Management Science that donor livers currently are doled ... regard for geography and demographics, an arrangement that prevents ...
... State University has secured a $7.9 million award ... through increasing the African nation,s agricultural productivity, creating ... grant, funded by the U.S. Agency for International ... of Florida. The initiative employs trilateral cooperation, which ...
... California A new research study from Loma Linda ... may help contribute to heart health and disease prevention; ... of The Journal of Nutrition . ... as tocopherols, plus numerous phenolic substances, many of them ...
Cached Medicine News:Health News:Scientists Say Newborn Mice Can Regrow Damaged Hearts 2Health News:New study shows ability of transgenic fungi to combat malaria and other bug-borne diseases 2Health News:New study shows ability of transgenic fungi to combat malaria and other bug-borne diseases 3Health News:New study shows ability of transgenic fungi to combat malaria and other bug-borne diseases 4Health News:PCBs Might Be Linked to Failed IVF Attempts 2Health News:Redesign of US donor-liver network could boost transplants by several hundred per year 2Health News:Redesign of US donor-liver network could boost transplants by several hundred per year 3Health News:$7.9 million grant to improve food security, nutrition in Mozambique 2Health News:Antioxidants in pecans may contribute to heart health and disease prevention 2
Interseal acetabular cup system addresses the contemporary issues of the two-piece cementless acetabular component design....
Optimal solution for normal acetabulum and younger patients....
The Pe-Plus offers an additional clinical option for replacing the acetabulum....
... integration of Trabecular Metal material ... design results in a fusion of ... meets surgeon demands for initial and ... wide variety of shell and liner ...
Medicine Products: