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FDA: Treatment With Angiotensin Receptor Blockers for High Blood Pressure Does Not Increase Risk of Cancer
Date:6/2/2011

SILVER SPRING, Md., June 2, 2011 /PRNewswire-USNewswire/ --The U.S. Food and Drug Administration today announced that a group of medications used to control high blood pressure, called angiotensin receptor blockers (ARBs), do not increase the risk of developing cancer in patients using the medications.

(Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO)

In July 2010, the FDA reported that a safety review of ARBs would be performed after a published study found a small increased risk of cancer in patients taking an ARB compared to those patients not taking an ARB.  http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm218845.htm.

For this safety review, the FDA evaluated 31 randomized clinical trials, comparing patients taking an ARB to patients not taking an ARB, looking for the incidence of cancer.  

"The FDA has completed its review of controlled trial data on more than 155,000 patients randomized to ARBs or other treatments—the largest evaluation of such data to date—and finds no evidence of an increased risk of cancer in patients who take an ARB," said Mary Ross Southworth, Pharm.D., deputy director for safety in the Division of Cardiovascular and Renal Drugs in the FDA's Center for Drug Evaluation and Research.

ARBs are medications used alone or in combination with other medications to treat high blood pressure and other heart-related conditions. A complete list is available in a Drug Safety Communication issued today http://www.fda.gov/Drugs/DrugSafety/ucm257516.htm.

Brand names include:

  • Atacand (candesartan)
  • Avapro (irbesartan)
  • Benicar (olmes
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SOURCE U.S. Food and Drug Administration
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