Navigation Links
FDA: Risk of Oral Birth Defects in Children Born to Mothers Taking Topiramate
Date:3/4/2011

SILVER SPRING, Md., March 4, 2011 /PRNewswire-USNewswire/ -- New data suggest that the drug Topamax (topiramate) and its generic versions increase the risk for the birth defects cleft lip and cleft palate in babies born to women who use the medication during pregnancy, the U.S. Food and Drug Administration said today.

(Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO)

Before prescribing topiramate, approved to treat certain types of seizures in people who have epilepsy, health care professionals should warn patients of childbearing age about the potential hazard to the fetus if a woman becomes pregnant while using the drug. Topiramate also is approved to prevent migraine headaches, but not to relieve the pain of migraines.  

"Health care professionals should carefully consider the benefits and risks of topiramate when prescribing it to women of childbearing age," said Russell Katz, M.D., director of the Division of Neurology Products in the FDA's Center for Drug Evaluation and Research. "Alternative medications that have a lower risk of birth defects should be considered."

Cleft lip and cleft palate, collectively called oral clefts, are birth defects that occur when parts of the lip or palate do not completely fuse together early in the first trimester of pregnancy, a time when many women do not know they are pregnant. The defects range from a small notch in the lip to a groove that runs into the roof of the mouth and nose, possibly leading to problems with eating, talking, and to ear infections. Surgery often is performed to close the lip and palate and most children do well after treatment.

Data from the North American Antiepileptic Drug (AED) Pregnancy Registry indicate an increased risk of oral clefts in infants exposed to topiramate during the first trimester of pregnancy. Infants exposed to topiramate as a single therapy experienced a 1.4 percen
'/>"/>

SOURCE U.S. Food and Drug Administration
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Progesterone Therapy and Preterm Birth: More Evidence Helps Identify Women Who Can Benefit
2. Male Birth Control Pill, Blackberry Extract for Gingivitis, Skin Cancer and Digestive Health Top List of New Medical Discoveries
3. Huge Drop in Preterm Birth-Risk Among Women Taking Folic Acid One Year Before Conception
4. Molecular Therapy Succeeds in Preventing Craniofacial Birth Defect in Mice
5. National Study Shows Magnesium Sulfate Reduces Risk of Cerebral Palsy in Premature Births
6. Infant Blood May Provide Insights into Diseases Present at Birth
7. Preterm Births Rise 36 Percent Since Early 1980s
8. New Study Proves Multiple Births From IVF Can Be Avoided
9. Taking Folic Acid for a Year Before Pregnancy May Reduce Risk of Preterm Birth
10. Diabetes Gene Raises Odds of Lower Birth Weight
11. Study Links Fetal Fibronectin Testing with Changes in Management Decisions for Symptomatic and Asymptomatic Women at Risk for Preterm Birth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/1/2015)... 1, 2015  Legendary actor and director Danny ... PBAFacts campaign designed to educate and encourage patients with ... Pseudobulbar Affect (PBA) and to speak with their physician. ... has the ability to cry and laugh on cue ... experienced by people living with PBA episodes. ...
(Date:5/1/2015)... , May 1, 2015 Semler Scientific, Inc. ... company that develops, manufactures and markets products that assist ... today reported financial results for the first quarter ended ... quarter of 2015, Semler reported continued progress with year ... quarter revenue growth of 14%," said Doug Murphy-Chutorian ...
(Date:5/1/2015)... Cambrex Corporation (NYSE: CBM ) reports results for the ... , Sales increased 18% compared to the first ... driven by Innovator products and Controlled Substances. , EBITDA ... quarter of 2014. , GAAP Diluted EPS from continuing ... year and Adjusted Diluted EPS was $0.29 compared to $0.07 ...
Breaking Medicine Technology:Danny Glover Joins PBA Facts Campaign, to Educate and Build Awareness of Pseudobulbar Affect (PBA), a Little Known but Widespread Neurologic Condition 2Danny Glover Joins PBA Facts Campaign, to Educate and Build Awareness of Pseudobulbar Affect (PBA), a Little Known but Widespread Neurologic Condition 3Semler Reports First Quarter 2015 Financial Results 2Semler Reports First Quarter 2015 Financial Results 3Semler Reports First Quarter 2015 Financial Results 4Semler Reports First Quarter 2015 Financial Results 5Cambrex Reports First Quarter 2015 Financial Results 2Cambrex Reports First Quarter 2015 Financial Results 3Cambrex Reports First Quarter 2015 Financial Results 4Cambrex Reports First Quarter 2015 Financial Results 5Cambrex Reports First Quarter 2015 Financial Results 6Cambrex Reports First Quarter 2015 Financial Results 7Cambrex Reports First Quarter 2015 Financial Results 8Cambrex Reports First Quarter 2015 Financial Results 9Cambrex Reports First Quarter 2015 Financial Results 10Cambrex Reports First Quarter 2015 Financial Results 11
(Date:5/2/2015)... (PRWEB) May 03, 2015 As one ... of the prestigious Safety and Health Achievement and Recognition ... honored to be chosen by the Illinois Department of ... has achieved and maintained SHARP certification by the Occupational ... 2006, as Essentra has continued to meet or exceed ...
(Date:5/2/2015)... 2015 Vancouver fencing company, QS Fencing, has ... advice to prospective clients related to their questions on railings ... railings around their decks and patios. While that seems like ... up once the person rolls up their sleeve to start ... railing in finding a gate that matches it. , Instead ...
(Date:5/2/2015)... Viejo, CA (PRWEB) May 02, 2015 ProText ... exclusively for use in Final Cut Pro X. ProText ... for use in Final Cut Pro X . ... single keyframe with Pixel Film Studios' ProText Kinetic 2. , ... Start by staggering two ProText Kinetic presets in the ...
(Date:5/2/2015)... (PRWEB) May 02, 2015 We are ... The Delray Recovery Center as one of the Top ... known in the addiction treatment field for their ethics ... to innovate and to continue their educational efforts. The ... workplace environment, never forgetting their purpose – to help ...
(Date:5/2/2015)... 2015 On Tuesday April 7th, the ... gathered to celebrate improvements in patient care. In 2014 ... (RVHP), had zero acquired ventilator associated infections, zero central ... ELCH was also recently named a Top Performer by ... ELCH credited the teamwork of staff from all departments ...
Breaking Medicine News(10 mins):Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 2Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 3Health News:Professional Staff at QS Fencing Company Now Provides Advice on Railings and Gates 2Health News:Pixel Film Studios Announced the Release of Protext Kinetic 2 for FPCX. 2Health News:The Delray Recovery Center Named 2015 Top Workplace 2Health News:East Liverpool City Hospital Celebrates Patient Care Improvements 2
... ... FAB-HOMES ™, a green home design studio based in Vancouver, Canada, is ... market. Fab-homes™ showcases a selection of modern, European dwellings planned along the ... 90% less energy for heating, cooling and building operation than a standard ...
... Dedicated ... ... mHealth Alliance today announced that it and the GSM Association will deliver a day-long ... the 2010 GSMA Mobile World Congress. A series of high-level presentations and seminar ...
... , The American Red Cross ... PHILADELPHIA , Feb. 11 Wednesday,s blizzard-like conditions ... Penn-Jersey Region.  The American Red Cross expected to see 1,300 ... drives were cancelled. , (Logo:   http://www.newscom.com/cgi-bin/prnh/20081216/DC52619LOGO  ) ...
... , ... make a $10 donation , WASHINGTON , ... phone users have made $10 donations to the American Red Cross ... 90999, raising a record-shattering $32 million in mobile giving for the ...
... MIAMI , Feb. 11 When the last school ... be putting down their pencils and papers in favor of video ... a price. That,s because children may be picking up something a ... the waistline. With a summertime stash of Explorer,s Bounty,s Gallop-A-Loozas line ...
... ... health care costs and improved health , ... Washington and San Francisco, CA (Vocus) February 11, 2010 -- The Integrated ... Lafarge North America Inc. with the IBI/NBCH Healthy Workforce Productivity Award at their ...
Cached Medicine News:Health News:FAB-HOMES™ Presents First Passive House Collection 2Health News:FAB-HOMES™ Presents First Passive House Collection 3Health News:mHealth Alliance Works in Partnership with GSMA to Expand Discussion of Mobile Health at 2010 Mobile World Congress 2Health News:mHealth Alliance Works in Partnership with GSMA to Expand Discussion of Mobile Health at 2010 Mobile World Congress 3Health News:Local Blood Supply Impacted by Wednesday's Severe Snow Storm 2Health News:Local Blood Supply Impacted by Wednesday's Severe Snow Storm 3Health News:Red Cross Raises More Than $32 Million Via Mobile Giving Program 2Health News:Red Cross Raises More Than $32 Million Via Mobile Giving Program 3Health News:Red Cross Raises More Than $32 Million Via Mobile Giving Program 4Health News:Red Cross Raises More Than $32 Million Via Mobile Giving Program 5Health News:Red Cross Raises More Than $32 Million Via Mobile Giving Program 6Health News:Explorer's Bounty Puffed Fruit Snacks Helping Parents Battle Summer Obesity 2Health News:Lafarge North America Recognized by IBI and NBCH for Health & Productivity Leadership 2Health News:Lafarge North America Recognized by IBI and NBCH for Health & Productivity Leadership 3
... Home Defibrillatorthe latest in essential safety ... deployed, Philips is the worldwide market ... and in airports, workplaces, communities, and ... is the first and only home ...
... Cadwell's custom bars have a large ... machined contacts (spaced 3 centimeters center-to-center) ... of repeated cleaning. Polarity indicators are ... snap-on handle fits our bar electrode ...
... custom bars have a large body ... contacts (spaced 3 centimeters center-to-center) to ... repeated cleaning. Polarity indicators are molded ... handle fits our bar electrode styles. ...
... The STAAR Collamer ICL and the ... lenses. Made of Collamer, STAARs proprietary collagen ... in the ciliary sulcus. This unique material ... provides excellent biocompatibility and superior optical capability. ...
Medicine Products: