Navigation Links
FDA: Risk of Oral Birth Defects in Children Born to Mothers Taking Topiramate
Date:3/4/2011

SILVER SPRING, Md., March 4, 2011 /PRNewswire-USNewswire/ -- New data suggest that the drug Topamax (topiramate) and its generic versions increase the risk for the birth defects cleft lip and cleft palate in babies born to women who use the medication during pregnancy, the U.S. Food and Drug Administration said today.

(Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO)

Before prescribing topiramate, approved to treat certain types of seizures in people who have epilepsy, health care professionals should warn patients of childbearing age about the potential hazard to the fetus if a woman becomes pregnant while using the drug. Topiramate also is approved to prevent migraine headaches, but not to relieve the pain of migraines.  

"Health care professionals should carefully consider the benefits and risks of topiramate when prescribing it to women of childbearing age," said Russell Katz, M.D., director of the Division of Neurology Products in the FDA's Center for Drug Evaluation and Research. "Alternative medications that have a lower risk of birth defects should be considered."

Cleft lip and cleft palate, collectively called oral clefts, are birth defects that occur when parts of the lip or palate do not completely fuse together early in the first trimester of pregnancy, a time when many women do not know they are pregnant. The defects range from a small notch in the lip to a groove that runs into the roof of the mouth and nose, possibly leading to problems with eating, talking, and to ear infections. Surgery often is performed to close the lip and palate and most children do well after treatment.

Data from the North American Antiepileptic Drug (AED) Pregnancy Registry indicate an increased risk of oral clefts in infants exposed to topiramate during the first trimester of pregnancy. Infants exposed to topiramate as a single therapy experienced a 1.4 percen
'/>"/>

SOURCE U.S. Food and Drug Administration
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Progesterone Therapy and Preterm Birth: More Evidence Helps Identify Women Who Can Benefit
2. Male Birth Control Pill, Blackberry Extract for Gingivitis, Skin Cancer and Digestive Health Top List of New Medical Discoveries
3. Huge Drop in Preterm Birth-Risk Among Women Taking Folic Acid One Year Before Conception
4. Molecular Therapy Succeeds in Preventing Craniofacial Birth Defect in Mice
5. National Study Shows Magnesium Sulfate Reduces Risk of Cerebral Palsy in Premature Births
6. Infant Blood May Provide Insights into Diseases Present at Birth
7. Preterm Births Rise 36 Percent Since Early 1980s
8. New Study Proves Multiple Births From IVF Can Be Avoided
9. Taking Folic Acid for a Year Before Pregnancy May Reduce Risk of Preterm Birth
10. Diabetes Gene Raises Odds of Lower Birth Weight
11. Study Links Fetal Fibronectin Testing with Changes in Management Decisions for Symptomatic and Asymptomatic Women at Risk for Preterm Birth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... - More than fifty years ago, Thalidomide was approved by ... mothers. Tragically, Thalidomide caused serious and permanent physical and emotional ... has been provided to survivors over the years from sources ... in 1991 and settlements from drug companies. ... provide support, we have a clear moral obligation to help ...
(Date:5/22/2015)... 2015 The leading companies in the ... cardiac rhythm management device market dominate their competition, ... St. Jude Medical, Boston Scientific and Asahi Kasei ... segment. The healthcare market research publisher,s report, ... as a base year, providing forecasts for each ...
(Date:5/22/2015)... ROCKVILLE, Md. , May 22, 2015 /PRNewswire/ ... "RegeneRx") today announced a peer-reviewed publication of the ... study evaluating RGN-259 (RegeneRx,s preservative-free eye drops) for ... Inc.,s controlled adverse environment (CAE ® ) model.  ... and the results, which were previously disseminated by ...
Breaking Medicine Technology:Statement from Minister Ambrose on Thalidomide 2Statement from Minister Ambrose on Thalidomide 3Kalorama: Top Companies Dominate Cardiac Defibrillator Market 2Kalorama: Top Companies Dominate Cardiac Defibrillator Market 3Kalorama: Top Companies Dominate Cardiac Defibrillator Market 4Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 2Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 3Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 4
... May 18, 2011 Ovid, part of ... the delivery of customizable electronic research information for the medical, scientific, ... OvidMD , the first clinical ... provides quick answers to clinical questions based on relevant full-text content ...
... FRANCISCO, May 18, 2011 Bayer HealthCare Pharmaceuticals, Inc. and ... that data evaluating the use of Nexavar® (sorafenib) tablets will ... Meeting of the American Society of Clinical Oncology (ASCO), June ... committed to researching the potential utility of sorafenib, and the ...
Cached Medicine Technology:Ovid Announces its First Clinical Tool, OvidMD, Designed for Physicians and Other Clinicians 2Ovid Announces its First Clinical Tool, OvidMD, Designed for Physicians and Other Clinicians 3Ovid Announces its First Clinical Tool, OvidMD, Designed for Physicians and Other Clinicians 4Nexavar Data to Be Presented at American Society of Clinical Oncology Annual Meeting 2Nexavar Data to Be Presented at American Society of Clinical Oncology Annual Meeting 3Nexavar Data to Be Presented at American Society of Clinical Oncology Annual Meeting 4Nexavar Data to Be Presented at American Society of Clinical Oncology Annual Meeting 5Nexavar Data to Be Presented at American Society of Clinical Oncology Annual Meeting 6Nexavar Data to Be Presented at American Society of Clinical Oncology Annual Meeting 7
(Date:5/23/2015)... May 23, 2015 Javon Bea ... the Sports Medicine and Rehabilitation Center, 557 N. Washington ... Mondays, June 1-July 20, 5:30-6:30 pm. , The 8-week ... and Laurie Finke, RN, BSN, who will offer training ... on nutrition, running mechanics and show selection and weekly ...
(Date:5/23/2015)... Baltimore, MD (PRWEB) May 23, 2015 Injury ... moratorium that has been passed by the Maryland legislature but ... , “The Maryland General Assembly passed HB 449 ... the Governor has not signed it into law. This bill ... 2017. Evidence is growing that demonstrates the danger of fracking ...
(Date:5/22/2015)... 22, 2015 Pioneer Millworks, the largest ... forefront of designing with reclaimed wood, introducing their latest ... Angeles, California. Their newest offerings, Vat 35, Reclaimed ... and color to America's largest design event. , “Designers, ... each show, anxious to see and feel the variety ...
(Date:5/22/2015)... Mountain Point Medical Center, a campus of Jordan Valley ... May 29, 2015 at 11 a.m., followed by a community ... center, set to officially open on June 1, 2015, is ... , “The opening of Mountain Point Medical Center is an ... said Kent Loosle, CEO of Mountain Point Medical Center. “Mountain ...
(Date:5/22/2015)... York, New York (PRWEB) May 22, 2015 ... http://www.xareltolawsuit2015.com/ ) filed on behalf of individuals who ... due to its use continue to move forward ... Louisiana. According to a Pretrial Order dated May ... the preservation of documents and electronically stored information. ...
Breaking Medicine News(10 mins):Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 3Health News:Pioneer Millworks to Reveal New Design Trends with Reclaimed Wood at Dwell on Design in LA 2Health News:Pioneer Millworks to Reveal New Design Trends with Reclaimed Wood at Dwell on Design in LA 3Health News:Mountain Point Medical Center, a Campus of Jordan Valley Medical Center, Hosts Ribbon Cutting Ceremony and Community Celebration on Friday, May 29, 2015 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 3Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 4
... cholesterol also control hypertension. // ,Researchers at Warwick ... using statins to reduce cholesterol get a bonus benefit from ... on blood pressure levels too. ,The researchers ... in blood pressure. The overall effect of the use of ...
... cases among the inmates of Tihar Jail in the national ... official report// said here Thursday. ,In 2006, 36 ... 12 in 2002, Minister of State for Home Affairs S. ... that regular health screening camps are being organised by the ...
... problem that has been long overlooked, President A.P.J. Abdul Kalam ... mentally ill women// who have no home. ,"While ... for themselves but also for their families, it becomes critical ... at the beginning of a two-day conference "Mental health - ...
... reminder of the penetration of kidney diseases worldwide. According to ... throes of kidney related ailments. ,Reputed nephrologists emphasized, ... detect the disease early. Kidney transplant and dialysis is simply ... ,Uncomplicated urine tests and blood tests can ...
... A new survey confirms that pulmonary/critical care physicians ... actively managing// their patients’ sleep problems. The survey ... Institute (ACCP-SI). It was found that most pulmonary/critical ... patterns of their female patients and are advising ...
... AMA has written to Health Minister, Tony Abbott, urging ... include funding guarantees// and performance benchmarks for medical training ... (AHCA) negotiations. ,The current AHCA expires ... soon. ,AMA President, Dr Mukesh Haikerwal, ...
Cached Medicine News:Health News:Nearly 2,500 Mentally Ill Women in Delhi are Destitute: Abdul Kalam 2Health News:Doctors Not Drowsy When Treating Women’s Sleep Issue 2Health News:Doctors Not Drowsy When Treating Women’s Sleep Issue 3
...
Knot tier...
... Blitz Suture Retriever is for arthroscopic and open ... design eliminates complicated procedural steps. It may ... suture material and in conjunction with,anchors or screws ... small, curved needle tip permits the placement of ...
... RC Retractor comes with several ... superficial or deep muscle retraction. ... retraction in three different directions: ... The fiber optic light cable ...
Medicine Products: