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FASgen Announces Significant Milestone in Its Cancer Drug Development Program
Date:10/1/2007

BALTIMORE, Oct. 1 /PRNewswire/ -- FASgen's fatty acid synthase inhibitor (FASi) compounds, led by FAS031, have demonstrated efficacy against every solid tumor xenograft cell line tested, in both orthotopic and flank models: 4 lung tumor cell lines (H460; A549; H1975; LX7); two ovarian; breast; and, colon. In many cases the tumors were eradicated entirely. The compounds have been shown in extensive preclinical studies to be remarkably safe and orally available. One compound was safely given to mice twice a day orally for 6 months with no observed adverse side effects except the elimination of the tumors. Other compounds were given to mice in a two year experiment and prevented the onset of tumors in nearly one-third of the mice. That experiment was repeated with a different compound and produced the same result. Several of these results have been recently published and others will shortly be published in leading oncology journals.

FASi is a new mechanism of action for the treatment of cancer. The fatty acid biosynthesis pathway is critical to all living organisms to produce fat and regulate the body's energy. In cancer cells, FASgen researchers over the last 15 years have discovered that the mechanism acts differently. As cancer cells do not produce fat, the fatty acid biosynthesis pathway in the transformed cell acts to regulate the energy source that keeps the cell alive. One critical enzyme in that pathway is FAS. The Company's researchers have discovered that inhibition of FAS kills the cancer cell, a result that has been recently replicated in a number of labs and become the subject of a series of new publications. FASgen has developed a library of FASi compounds and has an extensive body of intellectual property surrounding both the mechanism of action and uses for the compounds, and of course the composition of individual compounds. "This discovery holds out the prospect for a new method of treatment for cancer that is remarkably safe and may dimi
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SOURCE FASgen, Inc.
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