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Ezetimibe and Ezetimibe/Simvastatin Combo Pose No Increased Cancer Risk, Study Shows
Date:3/25/2009

country, based on a total of 559 million prescriptions for all of the cholesterol-lowering medications evaluated. The analysis found cancer reported in 2.9 per million prescriptions for ezetimibe, 1.3 per million prescriptions for ezetimibe/simvastatin therapy and an average of 4.1 per million prescriptions for other lipid lowering treatment. These rates demonstrate no increase in cancer for ezetimibe and ezetimibe/simvastatin regimen versus the other treatments studied.

"These data will hopefully return the conversation between physicians and patients back toward the most pressing public health risk in America -- unmanaged high LDL that can result in heart disease or stroke -- the nation's number one and number three killers," continued Dr. Karas.

This research, which explored three times more cancers than analyzed by Sir Richard Peto from the SEAS, SHARP and IMPROVE-IT studies published in the New England Journal of Medicine, September 2, 2008, is consistent with Peto's final report supporting no credible evidence that ezetimibe or ezetimibe/simvastatin increase the risk of developing cancer.

Funding Sources and Disclosures

No specific corporate funding was requested or obtained for data collection, analysis and publication of these findings. Dr. Karas has received speaker's fees and/or consulting fees from Merck, Abbott, and Schering-Plough. Dr. Alsheikh-Ali is a recipient of a faculty development award from Pfizer/Tufts Medical Center.


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SOURCE Tufts Medical Center
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