Navigation Links
Ezetimibe and Ezetimibe/Simvastatin Combo Pose No Increased Cancer Risk, Study Shows

- Journal of Clinical Lipidology publishes largest study comparing cancer risk of ezetimibe and ezetimibe/simvastatin to statin therapies using FDA database -

BOSTON, March 25 /PRNewswire-USNewswire/ -- A new study shows no increased cancer risk with ezetimibe mono and ezetimibe/simvastatin combination treatments, compared to cancer rates of other powerful lipid-lowering statin therapies. The study, conducted by Tufts Medical Center lipid and health policy experts, was published in the April issue of the Journal of Clinical Lipidology (

"This real-world examination shows no increased risk to patients taking ezetimibe alone or the ezetimibe/simvastatin combination to lower their lipid levels -- an issue that sparked many policy and health safety conversations," said lipidologist Richard Karas, MD, PhD, Professor of Medicine, Tufts University School of Medicine and Associate Director, Molecular Cardiology Research Institute, Tufts Medical Center, who co-authored the study along with Tufts Medical Center colleague, Alawi A. Alsheikh-Ali, MD, Institute for Clinical Research and Health Policy Studies.

Researchers at Tufts Medical Center and Tufts University School of Medicine studied rates of reports of cancer as an adverse event filed with the U.S. Food and Drug and Administration (FDA) for patients taking ezetimibe or ezetimibe/simvastatin compared to patients on mono-therapy with simvastatin, atorvastatin or rosuvastatin, during a four-year period. This is the first study to use the FDA database to evaluate potential cancer risk of cholesterol-lowering medications.

The Tufts researchers found 2,334 cases of cancers reported in the total population studied. Cancer rates were analyzed accounting for the number of prescriptions for each treatment dispensed across the country, based on a total of 559 million prescriptions for all of the cholesterol-lowering medications evaluated. The analysis found cancer reported in 2.9 per million prescriptions for ezetimibe, 1.3 per million prescriptions for ezetimibe/simvastatin therapy and an average of 4.1 per million prescriptions for other lipid lowering treatment. These rates demonstrate no increase in cancer for ezetimibe and ezetimibe/simvastatin regimen versus the other treatments studied.

"These data will hopefully return the conversation between physicians and patients back toward the most pressing public health risk in America -- unmanaged high LDL that can result in heart disease or stroke -- the nation's number one and number three killers," continued Dr. Karas.

This research, which explored three times more cancers than analyzed by Sir Richard Peto from the SEAS, SHARP and IMPROVE-IT studies published in the New England Journal of Medicine, September 2, 2008, is consistent with Peto's final report supporting no credible evidence that ezetimibe or ezetimibe/simvastatin increase the risk of developing cancer.

Funding Sources and Disclosures

No specific corporate funding was requested or obtained for data collection, analysis and publication of these findings. Dr. Karas has received speaker's fees and/or consulting fees from Merck, Abbott, and Schering-Plough. Dr. Alsheikh-Ali is a recipient of a faculty development award from Pfizer/Tufts Medical Center.

SOURCE Tufts Medical Center
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Independent Analyses of the SEAS, SHARP and IMPROVE-IT Studies of Ezetimibe
2. Results From the SEAS (Simvastatin and Ezetimibe in Aortic Stenosis) Study
3. Data Suggests New Antigen-Antibody Combo Test Useful for High Volume Public Health Screening
4. Drug Combo Could Lower Diabetes Complications and Costs
5. CyberKnife Radiosurgery for Lung Cancer Sees Increased Interest and Continued Rapid Growth
6. Genomas Clinical Study Finds Increased Prevalence of Drug Metabolism Deficiencies in Patients With Serious Psychotropic Side Effects
7. Long-term Follow Up Interim Data Show Nplate(TM) Increased and Sustained Platelet Counts in Adult Chronic ITP Patients
8. Observational Study Finds Changes in Medicare Reimbursement for Erythropoiesis-Stimulating Agents Associated With Increased Need for Blood Transfusion
9. GSK Reports PROMACTA(R) (eltrombopag) Significantly Increased Platelet Counts and Reduced Bleeding in Long-Term Study of Patients With Chronic ITP
10. Nebulized Perforomist(TM) Inhalation Solution Provided Prolonged Bronchodilation and Increased Patient Satisfaction Compared to Albuterol/Ipratropium MDI
11. Data Reported at ICAAC Indicates Selzentry(TM) Phase III Treatment-Naive Trial Shows Increased Efficacy When Used With Enhanced Trofile(TM) Assay
Post Your Comments:
(Date:6/24/2016)... , June 24, 2016 ... Market by Type (Standard Pen Needles, Safety Pen Needles), ... (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) ... MarketsandMarkets, This report studies the market for the forecast ... to reach USD 2.81 Billion by 2021 from USD ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... , June 23, 2016  In a startling report released today, ... their residents by lacking a comprehensive, proven plan to eliminate prescription ... definitive ranking of how states are tackling the worst drug crisis ... four states – Kentucky , New ... Vermont . Of the 28 failing states, three – ...
Breaking Medicine Technology:
(Date:6/27/2016)... ... June 27, 2016 , ... ... health professionals, announced today its affiliation with Tennessee Counseling Association. This ... the network of the Tennessee Counseling Association, adding exclusive benefits and promotional offers. ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer ... they remain in the eye of the beholder, according to experts who offered insights ... American Journal of Managed Care. For the full issue, click here . , ...
(Date:6/26/2016)... ... ... Kasmer, a legally blind and certified personal trainer is helping to develop a weight loss ... plans to fix the two major problems leading the fitness industry today:, ... , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
(Date:6/25/2016)... City, Oklahoma (PRWEB) , ... June 25, 2016 ... ... helping both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic ... the Oklahoma City area —Johnson is one of the first doctors to perform ...
Breaking Medicine News(10 mins):