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Express Scripts Study Finds No Association Between Anti-Epileptic Drug Switches and Increased Seizure Activity
Date:12/17/2009

ST. LOUIS, Dec. 17 /PRNewswire-FirstCall/ -- Express Scripts, Inc. (Nasdaq: ESRX), one of the largest pharmacy benefit management companies in North America, announced today results of a study that examined the association of seizure risk among epilepsy patients after switching between A-rated anti-epileptic drug formulations. The study found no evidence that switching between A-rated anti-epileptic drugs, including brand to generic substitution, was associated with increased emergency room visits or hospitalizations for epilepsy.

(Logo: http://www.newscom.com/cgi-bin/prnh/20080827/EXPRESSSCRIPTSLOGO)

The claims-based case-control study, conducted by Express Scripts, is the most comprehensive research to date of switching between A-rated anti-epileptic drugs. The research was designed to address methodological limitations of previous studies, and uses the largest sample size over the longest time frame of any study to date.

The results are available on-line and will be published in the February 2010 issue of Current Medical Research and Opinion (http://www.cmrojournal.com).

Concerns about switching between A-rated anti-epileptic drugs surfaced in the healthcare community after earlier findings suggested an association between anti-epileptic drug switching, particularly to lower-cost generic medications, and seizure activity. Anti-epileptic drugs are considered "narrow therapeutic index" drugs, thus i
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SOURCE Express Scripts
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