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Exosome Diagnostics and QIAGEN Partner to Launch Comprehensive Line of Biofluid Nucleic Acid Kits to Address Limitations of Tissue Biopsy in Clinical Research Market
Date:7/23/2013

o initiate therapy more rapidly and switch treatments before a patient's cancer worsens in a way that compromises their quality of life. Our clinical research focus is to define both response and resistance biomarkers to novel therapies, all of which can be enabled by exosomes."

James McKiernan, M.D., director of Urologic Oncology, Columbia University said, "The ability to achieve a stable, high quality RNA preparation directly from a simple urine sample has significant implications for interrogating the prostate, the bladder and the kidney on a molecular level, all non-invasively.  Through over 1,500 patient samples measured in clinical studies, we have shown that Exosome Diagnostics technology enables reproducible, sensitive measure of cancer specific molecular biomarkers directly from a simple, untreated urine sample."

Subject to successful completion of the solutions' performances, QIAGEN's exclusive agreement with Exosome Diagnostics will cover co-development, manufacturing and commercialization of a full product line for the life science and translational medicine markets. The product portfolio is also expected to create the basis development and commercialization of clinical in-vitro diagnostic products for a range of non-invasive personalized medicine solutions.

Exosomes and other extracellular vesicles can be isolated from biofluids such as blood, urine and cerebrospinal fluid and from which high quality nucleic acids, such as mRNA, miRNA and DNA, can be extracted and purified for analysis.  Exosomes are shed by all cells under both normal and pathological conditions. They are a key part of the body's complex communication system that transfers genetic instructions from cell to cell through all biofluids. Exosomes carry nucleic acids and proteins from their host cell, which are widely considered to be essential for biomarker discovery for personalized medicine diagnostics. Tumor cells, for i
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