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Exosome Diagnostics Presents Data Demonstrating Utility of Urine Exosome Technology to Predict Prostate Biopsy Outcome at American Urological Association Annual Meeting
Date:5/8/2013

officer of Exosome added, "These results are part of a multi-center clinical study program for EXO106, the first in vitro diagnostic in our exosome genitourinary (GU) oncology program.  EXO106 is being developed to provide patients and clinicians with a non-invasive diagnostic that can deliver real-time information following the finding of an elevated PSA.  We have now completed testing on over 1,000 urine samples from patient to characterize diagnostic performance."   

In the study presented by Dr. McKiernan, biopsy patients were divided into two cohorts. The first cohort was tested using a known prostate cancer biomarker, while a novel four-gene prostate cancer signature was tested in the second cohort.  Both groups were stratified based on whether their biopsies were positive or negative. Besides predicting positive biopsy outcome, exosome testing was able to distinguish histologically less aggressive, lower Gleason scores (≤7) cancers from those with higher, more aggressive Gleason scores (≥8). The results demonstrate that urinary exosome-derived RNA can be used to non-invasively evaluate gene expression in the prostate and accurately predict the likelihood of a positive or negative needle biopsy in addition to distinguishing more aggressive cancers.

This study was funded by the Prostate Cancer Foundation.

Exosome Diagnostics and its collaborators will also be presenting data on two other studies.

Abstract #13-7010, 3:30 to 5:30 p.m. PDT, May 6:  Urinary Exosomal RNA Provides a Non-Invasive Way to Accurately Detect PCA3 Expression in Men Undergoing Evaluation for Prostate Cancer,
Shapiro, E., Ahn, J.J., Zampella, B., Motamedinia, P., Scott, A., Salazar, G., Bate, K., Seaman, M., Badani, K., McKiernan, J.M., Russo L.
Exosome-derived PCA3 expression correlated well with the prostatic massage technique with a similar true positive rate.  Urinary exosome sampling captured
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SOURCE Exosome Diagnostics
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