Navigation Links
ExonHit's EHT 0202 Counters Scopolamine's Detrimental Effects on Cognition in Humans
Date:3/25/2008

ant decrease of the power in Delta and Theta bands (p<0.01) in subjects dosed at 40mg.

Cognitive improvement, as assessed by the analysis of P300 (an ERP wave) amplitude, was shown at an 80mg dose of EHT 0202 regardless the time post-dose (p <0.04). Moreover, the maximum effect of EHT 0202 80mg occurred at 4h15 post-dose and was associated with the ability to restore working memory function, while the deleterious effect of scopolamine reached its peak (p<0.02).

These findings add to EHT 0202's pharmacological properties elicited from preclinical studies in particular its ability to modulate GABA receptors and to redirect APP processing (which plays a pivotal role in the evolution of AD).

"EHT 0202 is not an acetylcholinesterase inhibitor. Evidence of EHT 0202's pharmacological activity is emphasized in young healthy subjects. Restoring the brain processes that are altered by scopolamine is indeed a very encouraging observation. It is a positive news flow for the future evaluation of EHT 0202 in Alzheimer's disease," declares Dr. Fitoussi, MD from MEDISCIS, the clinical research organisation which executed the clinical study.

Bruno Tocque, President of ExonHit's Management Board said "We are delighted to register this positive effect of our lead compound in this clinical Phase 1 trial. We now know that the compound, administered orally, has a pharmacological effect in man. A Phase 2 clinical trial is currently engaged in order to assess the safety and efficacy profile of EHT 0202 in patients suffering from AD. ExonHit's strategy is to provide therapeutic and diagnostic solutions in chronic diseases such as Alzheimer's disease, and we are committed to bring these innovations to the market".

About ExonHit Therapeutics

http://www.exonhit.com

ExonHit Therapeutics is the world's leader in the analysis of alternative RNA splicing, a process which when deregulated plays a key
'/>"/>

SOURCE ExonHit Therapeutics SA
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Study Compares Bronchodilatory Effects of SYMBICORT(R) and Advair in Adults With Asthma
2. Evanston Northwestern Healthcare Researchers Explain Effects of Large-Scale, Universal MRSA Surveillance Program That Supports Expanded Intervention
3. High Blood Pressure May Heighten Effects of Alzheimers Disease
4. FDA Confirms Seizure of Eyelash Product Was Not Prompted by Reports of Adverse Effects
5. New Analysis of METEOR Study Demonstrate Effects of AstraZenecas CRESTOR(R) (Rosuvastatin Calcium) on Atherosclerosis in Patients With Two or More Risk Factors for Cardiovascular Disease
6. Study Results Reveal alli(R) Patient Satisfaction Linked to Weight Loss Achieved; Not Treatment Effects
7. Symbollon Pharmaceuticals, Inc. Evaluates the Clinical Effects of IoGen(TM) on Fibrocystic Breast Disease
8. New Topical Therapy Safely Treats Serious Skin Infections Without Systemic Side Effects
9. ECLIPSE Data on Effects of Otsukas Investigational Novel Treatment, Tolvaptan, on Advanced Heart Failure Patients Hemodynamics and Urine Output Featured in Heart Failure Society of Americas Late Breaking Trials
10. Tablet PC Technology Helps Doctors and Patients Focus on Chemotherapy Side Effects, According to Thomson Healthcare Study
11. DNA Test Predicts Harmful Effects of Cancer Drug
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... Medela has announced the addition of ... Motion™-Endure personal pumps to its Negative Pressure Wound ... new devices, along with the Invia ® ... innovative, high-quality NPWT solutions, designed to provide safe ... "We are happy to be able to ...
(Date:3/31/2015)... 2015   Halyard Health (NYSE: HYH ... awarded a new purchasing agreement with HealthTrust ... 1, 2015, Halyard,s standard and ASTM-rated face masks ... be available to HealthTrust members made up of 1,350 ... centers, physician practices and alternate care facilities. ...
(Date:3/31/2015)... VANCOUVER, British Columbia , March 31, 2015 ... IMLFF), a clinical stage biopharmaceutical company that specializes ... announced the appointment of Paul C. Anderson ... Anderson is a pharma industry veteran who brings ... Dr. Anderson is a synthetic organic ...
Breaking Medicine Technology:Medela Launches Product Line to Support Individualized Care For Negative Pressure Wound Therapy Patients 2Halyard Health Signs First GPO Contracts As Independent Company 2Halyard Health Signs First GPO Contracts As Independent Company 3InMed Pharmaceuticals Strengthens Scientific Advisory Board 2InMed Pharmaceuticals Strengthens Scientific Advisory Board 3InMed Pharmaceuticals Strengthens Scientific Advisory Board 4
(Date:4/1/2015)... Eighty seven high schools from 29 states ... Casualty . Many of the schools have student populations ... fewer and fewer dollars allocated to sporting programs. , ... Thomas R. Brown, who recognized that teamwork and success ... its inception in 2011, over $400,000 has been awarded ...
(Date:4/1/2015)... The dearth of qualified laboratory ... to retire in the next five years) and ... laboratory automation. The application of advanced technology in ... timely progress and efficiency with minimal errors. This ... in high-throughput screening, combinatorial chemistry, automated clinical and ...
(Date:4/1/2015)... (PRWEB) April 01, 2015 Amada Senior ... living placement counseling, recently opened a new office in Rocky ... partners Tracy and Lee Bissett decided to make the move ... the area after over 20 years of experience in management ... April 2nd. , When asked what makes Amada ...
(Date:4/1/2015)... Orange, NJ (PRWEB) April 01, 2015 When ... as important as just finding some relief. Identifying the causes ... a solution. In many cases, the cause of chronic back ... more common than other diagnosable causes of back pain and ... PhD , founder and president of Atlantic Spine Center ...
(Date:4/1/2015)... April 01, 2015 On April 1st, 2015, Dr. ... a guest on Better TV to discuss the epidemic known as ... depending on the varying angle in which it is bent forward, ... weight on the cervical spine can cause poor posture often times ... more and more people spend hours on their cell phone device ...
Breaking Medicine News(10 mins):Health News:California Casualty Teams Up With 87 High Schools, Awarding Over $100,000 in 2015 Thomas R. Brown Athletics Grants 2Health News:California Casualty Teams Up With 87 High Schools, Awarding Over $100,000 in 2015 Thomas R. Brown Athletics Grants 3Health News:California Casualty Teams Up With 87 High Schools, Awarding Over $100,000 in 2015 Thomas R. Brown Athletics Grants 4Health News:California Casualty Teams Up With 87 High Schools, Awarding Over $100,000 in 2015 Thomas R. Brown Athletics Grants 5Health News:Laboratory Accessories Market Worth $504.7 Million by 2020 – New Research Report by MarketsandMarkets 2Health News:Laboratory Accessories Market Worth $504.7 Million by 2020 – New Research Report by MarketsandMarkets 3Health News:Amada Senior Care Expands to Eastern North Carolina 2Health News:Demystifying Facet Joint Syndrome 2Health News:Demystifying Facet Joint Syndrome 3Health News:Demystifying Facet Joint Syndrome 4Health News:Dr. Jason Helfrich, Co-Founder of 100% Chiropractic, is a Guest on Better TV to Discuss “Text Neck” 2
... patients at high risk of relapse, hematopoietic stem cell ... one of best options for treatment and a potential ... graft-versus-host disease (GVHD), a serious and often deadly post-transplant ... recognize the recipient,s own cells as foreign and react ...
... rules and meanings of your new home is especially challenging. ... journal of the Association for Psychological Science, finds that this ... after about the age of 15. Psychological scientists ... a critical windowif a developmental event doesn,t happen by a ...
... the release of two new provisional definitions of rheumatoid arthritis ... trials. According to research presented in the March ... RA who is enrolled in a clinical trial would need ... in remission: 1. Tender joint count, swollen joint ...
... News) -- Daily electronic records of symptoms can help ... a new study shows. Researchers gave 81 women ... patients used their PDA to report pain, sleep problems, ... for 30 days. The researchers at the University ...
... to "deactivate" migraine headaches produces lasting good results, with ... relief at five years, follow-up, reports a study in ... official medical journal of the American Society of Plastic ... migraine headaches were completely eliminated after surgery, according to ...
... that spring will come on time, and NASA satellite data ... are now anxious for the prediction to come true. ... last couple of days, including Phil,s home at Gobbler,s Knob ... rain this morning before it changed to snow as part ...
Cached Medicine News:Health News:Early infusion of donor T cells prevents graft versus host disease in blood cancer patients 2Health News:Early infusion of donor T cells prevents graft versus host disease in blood cancer patients 3Health News:Younger immigrants adjust to a new culture faster than do older immigrants 2Health News:Rheumatoid arthritis researchers redefine remission 2Health News:Rheumatoid arthritis researchers redefine remission 3Health News:Rheumatoid arthritis researchers redefine remission 4Health News:Migraine surgery offers good long-term outcomes 2Health News:GOES-13 Satellite sees Groundhog's Day on ice 2
Used for emergency airway access when conventional endotracheal intubation cannot be performed. Supplied sterile in peel-open packages. Intended for one-time use....
... Standard/Conventional Blade. Stainless steel. Lamp ... reliable tradition of high quality standard ... these blades have been continually refined ... world over to minimize maintenance requirements. ...
... are designed with the clinician in mind. ... be removed to simplify cleaning - no ... unique snap-on mechanism eliminates screws that can ... interchangeable with other green coded fiber optic ...
Stainless steel. Lamp is in fiberoptic handle. Green color coding. The blade includes a port that permits delivery of oxygen or other gas mixtures during intubation....
Medicine Products: