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ExonHit's EHT 0202 Counters Scopolamine's Detrimental Effects on Cognition in Humans
Date:3/25/2008

ant decrease of the power in Delta and Theta bands (p<0.01) in subjects dosed at 40mg.

Cognitive improvement, as assessed by the analysis of P300 (an ERP wave) amplitude, was shown at an 80mg dose of EHT 0202 regardless the time post-dose (p <0.04). Moreover, the maximum effect of EHT 0202 80mg occurred at 4h15 post-dose and was associated with the ability to restore working memory function, while the deleterious effect of scopolamine reached its peak (p<0.02).

These findings add to EHT 0202's pharmacological properties elicited from preclinical studies in particular its ability to modulate GABA receptors and to redirect APP processing (which plays a pivotal role in the evolution of AD).

"EHT 0202 is not an acetylcholinesterase inhibitor. Evidence of EHT 0202's pharmacological activity is emphasized in young healthy subjects. Restoring the brain processes that are altered by scopolamine is indeed a very encouraging observation. It is a positive news flow for the future evaluation of EHT 0202 in Alzheimer's disease," declares Dr. Fitoussi, MD from MEDISCIS, the clinical research organisation which executed the clinical study.

Bruno Tocque, President of ExonHit's Management Board said "We are delighted to register this positive effect of our lead compound in this clinical Phase 1 trial. We now know that the compound, administered orally, has a pharmacological effect in man. A Phase 2 clinical trial is currently engaged in order to assess the safety and efficacy profile of EHT 0202 in patients suffering from AD. ExonHit's strategy is to provide therapeutic and diagnostic solutions in chronic diseases such as Alzheimer's disease, and we are committed to bring these innovations to the market".

About ExonHit Therapeutics

http://www.exonhit.com

ExonHit Therapeutics is the world's leader in the analysis of alternative RNA splicing, a process which when deregulated plays a key
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SOURCE ExonHit Therapeutics SA
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