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Exiqon Forms Research Collaboration With M. D. Anderson Cancer Center
Date:5/27/2008

" said Gordon Mills, M.D., Ph.D., director of M. D. Anderson's Kleberg Center for Molecular Markers and chair of the Department of Systems Biology.

"We have been developing collaborative studies with industry leaders to bring novel technological approaches to achieve the mission of personalizing medicine at the Kleberg Center for Molecular Markers," said Rahul Mitra, Ph.D., associate director of the Kleberg Center.

About LNATM

LNAs are a class of nucleotide analogues that bind very strongly to RNA and DNA targets. By including LNAs in detection probes, it is possible to design very specific high-affinity detection assays for small RNA targets like miRNAs, which otherwise is not possible using standard DNA based detection probes.

About miRNA

microRNAs (miRNAs) are a novel class of regulatory RNA molecules with surprisingly widespread effects on gene regulation. Although recently identified as a class of molecules, initial studies indicate that miRNAs may regulate as much as 1/3 of all genes in the genome, thus comprising an up till now hidden level of regulation. Interestingly, miRNAs have already been found to play important roles in several types of cancers and in processes involved in cellular differentiation. In the cell, miRNAs are found in form of single-stranded RNA molecules, which are typically 20-25 nucleotides long in their active form.

About breast cancer

Breast cancer is one of the most prevalent cancers estimated to world wide affect approximately 1 million women annually. The standard diagnostics for breast cancer is based on histology as well as molecular markers such as Estrogen-receptor (ER) and Progesterone-receptor (PR) protein status. The primary treatment for breast cancer is surgery and radiation, followed by adjuvant chemotherapy. However, 70-80% of patients receiving this treatment will survive without it, and therefore there is a need for diagnostic tests that help patients and doctors decide
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SOURCE Exiqon A/S
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