Navigation Links
Exercise Performance in Children and Young Adults with Single Ventricle Heart Disease Improves with Use of Drug for Erectile Dysfunction
Date:3/10/2011

pposite treatment course.  As a "proof-of-concept" study, the researchers selected a relatively healthy cohort of subjects without significant complications that they felt would have sufficient exercise capacity to complete the study.

The researchers found significant improvements in exercise performance during treatment with sildenafil compared to placebo.  The findings included improved ventilatory efficiency and, in two subgroups of patients, an improved ability to perform moderate levels of exercise. These changes suggest an overall improvement in the physiology associated with this unique circulation.

"The enhanced exercise performance that we found in the study is exciting and may lead to an improvement in day to day activities for these children and young adults," Dr. Goldberg said.  "However, it is important to note that while the results of this study are encouraging, more work is needed to determine whether the short-term benefit found in this study holds up over a longer period of time and whether there are any long-term side effects," he added.

"If the results from this preliminary study are validated in a larger sample over a longer period of time, it may be that this medication has the potential to improve quality of life for patients born with only one ventricle," Dr. Goldberg concluded.

Dr. Goldberg's coauthors were Michael McBride, Ph.D., Bradley Marino, M.D., Nicole Mirarchi, M.D., Brian D. Hanna, M.D., Gil Wernovsky, M.D., Stephen M. Paridon, M.D., and Jack Rychik, M.D., all from The Children's Hospital of Philadelphia; and Benjamin French, M.D., from the University of Pennsylvania School of Medicine.

Grants from The Mark H. and Blanche M. Harrington Foundation and from Big Hearts to Little Hearts provided funding for this study. Dr. Goldberg received support from the NIH T32 grant HL07915.

About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Dendreon Announces Exercise and Closing of Overallotment Option
2. EIB Active™ Campaign and Celebrity Nanny Jo Frost Kick Off 2011 in Los Angeles to Educate Families About Asthma and Exercise-Induced Bronchospasm (EIB)
3. Pharmasset Announces Exercise of Underwriters Overallotment Option
4. Amarin Announces Underwriters Exercise of Over-Allotment Option
5. American Council on Exercise (ACE) Announces Nationwide Effort to Eliminate Obesity in America
6. Cephalon Exercises its Option to Acquire BioAssets Development Corporation
7. Regeneron Announces Exercise of Over-Allotment Option and Closing of Underwritten Offering of Common Stock
8. MAP Pharmaceuticals Announces Exercise of Over-Allotment Option and Closing of Underwritten Offering of Common Stock
9. BioMed Realty Trust Announces Exercise of Over-Allotment Option for Common Stock
10. Advanced Life Sciences Receives $1.5 Million From Exercise of Unit Warrants and Secures Financing Commitment
11. ProUroCare Medical Announces Offering of Replacement Warrants in Exchange for Early Exercise of Outstanding Warrants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2015)... 24, 2015 Research and Markets ( ... "Global Biobanking Market 2015-2019" report to their offering. ... to grow at a CAGR of 7.07% over the ... be divided into two segments: Equipment and Consumables. This ... of the Global Biobanking market for the period 2015-2019. ...
(Date:4/24/2015)... -- Introduction of new "Elements" ... for radiosurgery/SBRT   The "Elements" strategy ... the workflow for difficult to treat indications in ... comes full circle with the introduction of automated ... enable on-the-fly generation of consistent treatment plans for ...
(Date:4/24/2015)... April 24, 2015 The National Institute ... the National Institutes of Health [NIH])  provided grants ... projects for the development of diagnostic tests for ... outbreaks at U.S. health facilities , the NIAID ... rapid, multiplexed and effective tests using alternative methods ...
Breaking Medicine Technology:Global Biobanking Market Report 2015-2019 - Increase in Strategic Collaborations with Beckman Coulter, Tecan & Thermo Fischer Scientific Dominating 2Brainlab Introduces New Generation of VMAT* for Brain and Spine at 3rd ESTRO in Barcelona 2Kalorama: NIAID Rewards HAI Innovators with Grants 2Kalorama: NIAID Rewards HAI Innovators with Grants 3Kalorama: NIAID Rewards HAI Innovators with Grants 4
(Date:4/25/2015)... New Jersey (PRWEB) April 25, 2015 ... people aged twelve and above needed treatment for an ... according to the Substance Abuse and Mental Health Services ... September 2011). Beyond these alarming numbers are harrowing stories ... by substance abuse . David H. Kerr ...
(Date:4/25/2015)... Henderson, NV (PRWEB) April 25, 2015 ... Program is still eliciting the excitement of the public ... well into the months of May and June. ... Wellness™ held their biannual tradition of "Special Prayers." More ... who had attended previous Special Prayers and have reported ...
(Date:4/25/2015)... New York New York (PRWEB) April 25, 2015 ... announce that Dr. Jerry Blaivas has been chosen by the ... Award for his contributions to medicine in the field of ... as the best in his speciality, Genito-Urinary diseases. He ... medicine, specifically in the field of urology. Not only ...
(Date:4/24/2015)... Bird B Gone, the leader in bird ... a complete line of bird control solutions to address the ... Flu Strains Threaten Pacific, Central and Mississippi Farms , According ... a number of highly pathogenic avian flus in the Pacific, ... spread when wild birds enter poultry farms. The USDA urges ...
(Date:4/24/2015)... 24, 2015 Ryadon is a leading ... of capabilities and services to complement any custom hardware ... Discount Program will be offered on all heavy duty ... 4-19: Receive 10% discount - Order 20+: Receive 20% ... Drawer Slides Products, Furniture ...
Breaking Medicine News(10 mins):Health News:New Book Features Powerful Stories of People Who Overcame Addiction 2Health News:New Book Features Powerful Stories of People Who Overcame Addiction 3Health News:Trivedi Master Wellness™ Announces the Resounding Success of their Special Prayers Human Wellness Program 2Health News:Trivedi Master Wellness™ Announces the Resounding Success of their Special Prayers Human Wellness Program 3Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 2Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 3Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 2Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 3Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 4Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 2Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 3
... the third of five papers in the PLoS Medicine ... Africa, Sara Bennett and Freddie Ssengooba this week discuss the ... from Johns Hopkins University in Baltimore USA, and Dr Ssengooba ... basis for improving maternal, newborn, and child health (MNCH) in ...
... induce specific epigenetic changes and gene mutations that may be ... online study published June 29 in the Journal of ... a risk factor for colorectal cancer, with a recent meta-analysis ... past are 18% more likely to develop colorectal cancer than ...
... TUESDAY, June 29 (HealthDay News) -- Intensive control of ... disease for those with long-term type 2 diabetes who are ... it may have some other benefits, a new analysis suggests. ... a certain group of patients may slow progression of eye ...
... ... for employers who want to provide health benefits and control costs., , ... Minneapolis, MN (PRWEB) June 29, ... the largest independent insurance and employee benefits brokers in the Midwest, to offer customized ...
... use has decreased drastically over the last few decades, we ... Physicians (ACP) President, J. Fred Ralston, Jr., MD, FACP, said ... In Tobacco Control and Prevention, ACP called for a comprehensive ... actions being taken by states currently. "A comprehensive tobacco ...
... Ohio State University Comprehensive Cancer Center-Arthur G. James ... (OSUCCC-James) have discovered how a substance that is ... block the proliferation of cancer cells. Compelling ... have anticancer effects and other health benefits, the ...
Cached Medicine News:Health News:Smoking-related colorectal cancer in older women is associated with molecularly-defined DNA changes 2Health News:Tight Blood Sugar Control in Older Diabetics May Not Reduce Heart Risk 2Health News:Tight Blood Sugar Control in Older Diabetics May Not Reduce Heart Risk 3Health News:Bloom Health and Christensen Group Partner Together to Deliver Innovative Solution 2Health News:Internists outline comprehensive federal strategy to control tobacco use 2Health News:Study shows how dietary supplement may block cancer cells 2
The New Vantage Plus. The PLUS gives you: ,P Premium intelligent optics ,L Lighter weight and brighter images ,U Unique wireless patented technology ,S Smaller and more compact size ...
STAT-CRIT is a rapid, one-step system for measuring hematocrit....
... Simple, compact, and easy to use, ... surgery technology to every OR. The business ... provide hospitals and surgeons with the most ... their facilities. ,The z-boxTM is designed to ...
...
Medicine Products: