Navigation Links
Exercise Performance in Children and Young Adults with Single Ventricle Heart Disease Improves with Use of Drug for Erectile Dysfunction
Date:3/10/2011

pposite treatment course.  As a "proof-of-concept" study, the researchers selected a relatively healthy cohort of subjects without significant complications that they felt would have sufficient exercise capacity to complete the study.

The researchers found significant improvements in exercise performance during treatment with sildenafil compared to placebo.  The findings included improved ventilatory efficiency and, in two subgroups of patients, an improved ability to perform moderate levels of exercise. These changes suggest an overall improvement in the physiology associated with this unique circulation.

"The enhanced exercise performance that we found in the study is exciting and may lead to an improvement in day to day activities for these children and young adults," Dr. Goldberg said.  "However, it is important to note that while the results of this study are encouraging, more work is needed to determine whether the short-term benefit found in this study holds up over a longer period of time and whether there are any long-term side effects," he added.

"If the results from this preliminary study are validated in a larger sample over a longer period of time, it may be that this medication has the potential to improve quality of life for patients born with only one ventricle," Dr. Goldberg concluded.

Dr. Goldberg's coauthors were Michael McBride, Ph.D., Bradley Marino, M.D., Nicole Mirarchi, M.D., Brian D. Hanna, M.D., Gil Wernovsky, M.D., Stephen M. Paridon, M.D., and Jack Rychik, M.D., all from The Children's Hospital of Philadelphia; and Benjamin French, M.D., from the University of Pennsylvania School of Medicine.

Grants from The Mark H. and Blanche M. Harrington Foundation and from Big Hearts to Little Hearts provided funding for this study. Dr. Goldberg received support from the NIH T32 grant HL07915.

About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Dendreon Announces Exercise and Closing of Overallotment Option
2. EIB Active™ Campaign and Celebrity Nanny Jo Frost Kick Off 2011 in Los Angeles to Educate Families About Asthma and Exercise-Induced Bronchospasm (EIB)
3. Pharmasset Announces Exercise of Underwriters Overallotment Option
4. Amarin Announces Underwriters Exercise of Over-Allotment Option
5. American Council on Exercise (ACE) Announces Nationwide Effort to Eliminate Obesity in America
6. Cephalon Exercises its Option to Acquire BioAssets Development Corporation
7. Regeneron Announces Exercise of Over-Allotment Option and Closing of Underwritten Offering of Common Stock
8. MAP Pharmaceuticals Announces Exercise of Over-Allotment Option and Closing of Underwritten Offering of Common Stock
9. BioMed Realty Trust Announces Exercise of Over-Allotment Option for Common Stock
10. Advanced Life Sciences Receives $1.5 Million From Exercise of Unit Warrants and Secures Financing Commitment
11. ProUroCare Medical Announces Offering of Replacement Warrants in Exchange for Early Exercise of Outstanding Warrants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... , May 29, 2015 LifeNet Health plans ... hiring for 2015 to more than 160 people. ... demand for LifeNet Health,s innovative bio-implants, which are being ... patients to be served. It also is a reflection ... "The growth and success of LifeNet Health ...
(Date:5/29/2015)... and MENLO PARK, Calif. ... DelMar Pharmaceuticals, Inc. (OTCQX: DMPI) ("DelMar" and ... and commercializing proven cancer therapies in new orphan ... American Association of Cancer Research (AACR) Advances ... potential for its lead product candidate VAL-083 ...
(Date:5/29/2015)... Educating the community continues to be ... Advancement of Wound Care (AAWC), which was incorporated ... corporate partners, the Association provides medical professionals with ... website at http://aawconline.org/education-for-the-generalist/ . The portal is ... to various CME/CEU educational programs. This education is ...
Breaking Medicine Technology:LifeNet Health to add more than 160 jobs in 2015 2DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 2DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 3DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 4DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 5The Association for the Advancement of Wound Care Educates the Public 2
... Md., Nov. 7, 2011 The U.S. Food and ... chemotherapy to treat patients with late-stage (metastatic) head and ... Combined with chemotherapy, Erbitux extended the ... those receiving chemotherapy alone. Erbitux already is FDA-approved for ...
... 2011 MAQUET Cardiovascular, a global leading provider ... received U.S. Federal Trade Commission (FTC) approval to ... device technologies for interventional cardiology and radiology, chest ... general surgery, and has subsequently closed the previously ...
Cached Medicine Technology:FDA Approves Erbitux to Treat Late-stage Head and Neck Cancer 2FDA Approves Erbitux to Treat Late-stage Head and Neck Cancer 3MAQUET Cardiovascular Completes Acquisition of Atrium Medical Corporation 2MAQUET Cardiovascular Completes Acquisition of Atrium Medical Corporation 3
(Date:5/29/2015)... “In the current environment of ... regulations, we provide education that will help practitioners ... suffering from pain, within the boundaries of the ... of rehabilitation medicine and President/Medical Director of the ... , A new flight of PAINWeekEnd Regional Conferences ...
(Date:5/29/2015)... Ready to hit the road? Before embarking on a big ... vehicles ready. With handicapped vehicles, there are even more things ... ready to help drivers get their handicapped vans ready by ... When planning for the big trip, drivers should be sure ... smoothly and they are prepared for all contingencies: , ...
(Date:5/29/2015)... The science of hair restoration has taken ... the efforts of internationally recognized hair transplant surgeon Dr. ... hair restoration and manual FUE techniques to offer ... , A Follicular Unit Extraction (FUE) is ... grafts from the donor areas of a patient. ...
(Date:5/29/2015)... 2015 The third annual Newport 10 ... closed to new registration, starts outside the east wall ... competitive running event demonstrates the power of combining professional ... benefit – in this case, historic preservation. , ... famed Ocean Drive and passes by many Bellevue Avenue ...
(Date:5/29/2015)... Abinton, PA (PRWEB) May 29, 2015 ... selected to be among the first hospitals in ... to enhance maternity care practices and work ... is a hospital-based quality-improvement initiative focusing on maternity ... the Centers for Disease Control and Prevention, EMPower ...
Breaking Medicine News(10 mins):Health News:PAINWeekEnd Kansas City: Pain Management CME for the Main Street Practitioner 2Health News:Advanced Driving Systems Offers Tips for Summer Road Trips 2Health News:Advanced Driving Systems Offers Tips for Summer Road Trips 3Health News:Los Angeles and Beverly Hills Hair Transplant Doctor Now Combines Robotic Hair Restoration (ARTAS) and Manual FUE Transplants for Maximum Hair Coverage 2Health News:The Newport 10 Miler at Fort Adams, an Outstanding Example of Event Marketing Helping in Preservation, is Now Completely Booked for 2015 2Health News:The Newport 10 Miler at Fort Adams, an Outstanding Example of Event Marketing Helping in Preservation, is Now Completely Booked for 2015 3Health News:Abington Hospital Selected to Join Baby-Friendly Hospital Initiative 2
... than pills, whenever possible, , MONDAY, March 29 (HealthDay ... but that daily multivitamin pill, calcium supplements and possibly ... say that getting crucial nutrients from food, when possible, ... Association, in fact, has updated its guidelines on nutrient ...
... team at the Sahlgrenska Academy at the University of Gothenburg, ... enzymes could be targets for the treatment of lung cancer. ... of the two enzymes in transgenic mice. This resulted in ... the mice. The article is being published in the ...
... release is available in Spanish . , ... fat and fewer calories, thanks to work by Agricultural ... based at the ARS National Center for Agricultural Utilization ... her Peoria laboratory, Singh is formulating low-fat cake mixes ...
... ... – including a “Describe How You Feel” tool – to help patients put their symptoms ... ... are now available on www.letstalkibs.com to help patients living with irritable bowel ...
... ... help make moving easy. , ... (PRWEB) March 29, 2010 -- On March 8, Barrett Moving & Storage ... grown moving company’s multiple service areas—including various household moves, corporate relocations, high value shipments ...
... ... product development. , ... Toronto, ON (Vocus) March 29, 2010 -- Therapure Biopharma Inc. today announced a fill/finish ... Under the terms of the agreement, Therapure will provide custom fill/finish services for a ...
Cached Medicine News:Health News:To Supplement or Not to Supplement? 2Health News:To Supplement or Not to Supplement? 3Health News:Promising strategy for treatment of lung cancer 2Health News:LetsTalkIBS.com Helps Patients Start the Conversation about Irritable Bowel Syndrome 2Health News:Minnesota Moving Company, Barrett Moving & Storage Launches New Online Look at www.barrettmoving.com 2Health News:Therapure Biopharma Inc. signs fill/finish contract with Kane Biotech Inc. 2
... a robust and durable drainage system. Preplaced ... globe. Pressure Ridge Molteno Implants have a ... tissue, acts as a Pressure sensitive biological ... implants allows the surgeon to choose the ...
... a low implant profile, 0.84mm, for better ... insertion is technically simpler and allows a ... installed with less trauma than multiple quadrant ... implant were designed to minimize bleb height ...
1-Meter Roll-Up Tangent Screen....
... accurate detections of any ... as glaucoma in the ... performed. Smooth operation of ... High accuracy of static ...
Medicine Products: