Navigation Links
Exelixis Reports Top-Line Results of the Phase 2 Trial of XL784 in Patients With Proteinuria Associated With Diabetic Nephropathy
Date:10/16/2007

multi-site phase 2 trial of XL784 was designed to enroll approximately 130 diabetic patients who have clinically significant proteinuria. Participants were randomly assigned to receive 200mg of XL784 or placebo daily for three months. The primary endpoint of the trial was a significant reduction in proteinuria compared with placebo. Secondary endpoints included changes in renal function and cardiovascular events.

About XL784

XL784 was the first small molecule compound developed by Exelixis, using its proprietary drug discovery engine. The compound is a potent inhibitor of the ADAM-10 and MMP-2 metalloprotease enzymes, targets of significant interest because of their important role in renal fibrosis and impairment. XL784 was specifically optimized to be matrix metalloprotease-1 (MMP-1) sparing, thus potentially significantly enhancing its safety profile and enabling higher dosing compared with other previously studied metalloprotease inhibitors. Results of single and repeat dose phase 1 clinical trials of XL784 administered orally to 70 healthy volunteers demonstrated that XL784 has attractive safety and pharmacokinetic profiles.

About Exelixis

Exelixis, Inc. is a development-stage biotechnology company dedicated to the discovery and development of novel small molecule therapeutics for the treatment of cancer and other serious diseases. The company is leveraging its fully integrated drug discovery platform to fuel the growth of its development pipeline, which is primarily focused on cancer. Currently, Exelixis' broad product pipeline includes investigational compounds in phase 2 and phase 1 clinical development for cancer and renal disease. Exelixis has established strategic corporate alliances with major pharmaceutical and biotechnology companies, including GSK, Bristol-Myers Squibb, Genentech, Wyeth Pharmaceuticals and Daiichi-Sankyo. For more information, please visit the company's web site at

SOURCE Exelixis, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Six Abstracts Featuring Exelixis Compounds Accepted At ASCO Conference
2. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
3. Cobalis Reports Phase III Trial Results for PreHistin in Seasonal Allergic Rhinitis
4. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
5. Cytos Biotechnology Reports Results from Phase IIa Study with CYT003-QbG10 in Patients Suffering from Atopic Dermatitis
6. Cytokinetics Reports Additional Clinical Trials Data for Ispinesib
7. The European Myeloma Platform Reports New Survival data for Revlimid Presented at the International Myeloma Workshop in Greece
8. Cytochroma Reports Positive Phase I Clinical Data for CTA018 Injection
9. Speedel Reports Successful SPP635 Phase IIa Trial in Hypertension
10. Columbia Laboratories Reports Positive Results from Multi-dose Pharmacokinetic Study of Vaginally-administered Lidocaine
11. CytRx Reports Promising Data from Its Open-Label Extension Clinical Trial of Arimoclomol in ALS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2015)... HILL, S.C. , April 23, 2015 ... on and strengthening our commitment to patient safety. ... in the fight against infectious disease. The ... Medical gas sensors are now mounted in ... reducing the need to open ceiling tiles potentially releasing ...
(Date:4/23/2015)... April 23, 2015 Nektar Therapeutics (Nasdaq: NKTR ... ended March 31, 2015 on Thursday, April 30, 2015, after ... president and chief executive officer, will host a conference call ... (ET)/2:00 p.m. Pacific Time (PT). The press ... can be accessed through a link that is posted on ...
(Date:4/23/2015)... 23, 2015  DanDrit Biotech A/S ("DanDrit Denmark"), ... , Inc. ("DanDrit"), (symbol : OTCQB:DDRT) a ... for the treatment of colorectal cancer, announced that ... signed a partnership agreement in Saudi ... advances DanDrit,s goal to deliver an innovative portfolio ...
Breaking Medicine Technology:BeaconMedaes launches new Zone Valve Box Assembly 2Nektar to Announce Financial Results for the First Quarter 2015 on Thursday, April 30, 2015, After Close of U.S.-Based Financial Markets 2DanDrit Biotech and Riyadh Pharma Sign Partnership Agreement 2
... 2011 Henry Schein, Inc. (NASDAQ: ... services to office-based practitioners, announced today that Ferdinand ... the CL King 9th Annual Best Ideas Conference 2011. The ... New York City. Henry Schein,s presentation is ...
... VILLAGE, Nev., Sept. 13, 2011 PDL BioPharma, Inc. (PDL) ... McLaughlin, the company,s president and chief executive officer, will present ... ) UBS Global Life Sciences Conference ... The JMP Securities Healthcare Conference Tuesday, ...
Cached Medicine Technology:Henry Schein to Present at the CL King 9th Annual Best Ideas Conference 2011 2
(Date:4/25/2015)... York New York (PRWEB) April 25, 2015 ... that Dr. Jerry Blaivas has been chosen by the New ... for his contributions to medicine in the field of Urology. ... the best in his speciality, Genito-Urinary diseases. He was ... specifically in the field of urology. Not only did ...
(Date:4/25/2015)... (PRWEB) April 25, 2015 On Friday, ... of RFID Journal’s annual Best Implementation Award. This ... demonstrated the best use of RFID technology to improve ... is the company that best demonstrates how RFID is ... presented at RFID Journal Live! 2015 in San Diego, ...
(Date:4/24/2015)... 24, 2015 Bird B Gone, the leader ... now offers a complete line of bird control solutions to ... , New Flu Strains Threaten Pacific, Central and Mississippi Farms ... , a number of highly pathogenic avian flus in ... is often spread when wild birds enter poultry farms. The ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 Multi Customer ... septic tank pumping ( http://www.zeitersseptics.com/multi-customer-discount.html ) of 1000-1500 gallons ... start the program. This does not include any Dig ... Save $25-$65 per person. If someone is part of ... two tanks totaling approximately 2500 gallons or more, the ...
(Date:4/24/2015)... 2015 Ryadon is a leading manufacturer ... capabilities and services to complement any custom hardware requirements ... Program will be offered on all heavy duty drawer ... Receive 10% discount - Order 20+: Receive 20% discount ... Slides Products, Furniture ,Drawer ...
Breaking Medicine News(10 mins):Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 2Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 3Health News:Seeonic’s Industry Leading Technology Powers Interstate Batteries to Winning Award 2Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 2Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 3Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 4Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 2Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 3Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 2Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 3
... N.Y., JAN. 5, 2009 Only 17 percent of ... are taking a multivitamin containing folic acid daily, according ... to focus on this population. , Folic acid ... of the brain and spine such as spina bifida ...
... Jan. 5 Only 17 percent of Spanish-speaking women ... a multivitamin containing folic acid daily, according to the ... on this population. Folic acid can prevent neural tube ... spine such as spina bifida and anencephaly, which are ...
... Volcano Corporation,(Nasdaq: VOLC ), a leader ... diagnosis and treatment of coronary and peripheral artery,disease, will ... to,discuss its acquisition of Axsun Technologies, Inc., that was ... The teleconference call and webcast will begin at 1 ...
... Conference on Cell Therapy for Cardiovascular Disease (IC3D) will ... organ injury. The session will include new data on ... cells for stroke patients, and treating Parkinson,s disease with ... include the first human data using special bone marrow ...
... Newswire Staff Volunteer Time As Part of ... Jan. 5 Ronald McDonald House of Cleveland ... non-profit organizations serving the Cleveland community, were the ... from PR Newswire,s Cleveland staff in 2008, PR ...
... OF THE AMERICAN SOCIETY OF PLASTIC SURGEONSARLINGTON HEIGHTS, Ill., ... the American Society of Plastic Surgeons:Can The US Really ... that while health care is one of the strongest ... sustainable reduction is US health care spending is not ...
Cached Medicine News:Health News:Folic acid survey of Spanish-speaking women finds most are missing benefits, March of Dimes says 2Health News:First Nationwide Folic Acid Survey of Spanish-Speaking Women Finds Most Are Missing Benefits, March of Dimes Says 2Health News:First Nationwide Folic Acid Survey of Spanish-Speaking Women Finds Most Are Missing Benefits, March of Dimes Says 3Health News:Reminder: Volcano Corporation Schedules Conference Call, Webcast to Discuss Axsun Transaction 2Health News:Conference on cell therapy includes new session on stem cells for non-cardiac organ injury 2Health News:PR Newswire Provides Grant to Ronald McDonald House and Habitat for Humanity in Cleveland 2Health News:PR Newswire Provides Grant to Ronald McDonald House and Habitat for Humanity in Cleveland 3Health News:PR Newswire Provides Grant to Ronald McDonald House and Habitat for Humanity in Cleveland 4Health News:PR Newswire Provides Grant to Ronald McDonald House and Habitat for Humanity in Cleveland 5Health News:Plastic and Reconstructive Surgery...In Brief 2Health News:Plastic and Reconstructive Surgery...In Brief 3
HME w/CO2 Sampling Port 22mm od/15mm od...
... T helps provide protection to the exposed airway ... extremely lightweight making it ideal for active young ... rate of heat and moisture recovery, it ensures ... HMEs and filters have ISO standard tapered ends ...
... provide protection to the exposed airway of the ... making it ideal for active young children as ... heat and moisture recovery, it ensures patient comfort ... filters have ISO standard tapered ends to assure ...
The Secretion Solution., ,Available Configurations: , Straight Flex Tube, Poppel Flex Tube, MDI Adaptor ...
Medicine Products: