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Exelixis Reports Top-Line Results of the Phase 2 Trial of XL784 in Patients With Proteinuria Associated With Diabetic Nephropathy
Date:10/16/2007

eing held in San Francisco from October 31 - November 5, 2007. In addition, following the presentation, Exelixis will hold a briefing for analysts and investors from 12:15 PM - 1:15 PM, Pacific Daylight Time, at the W Hotel in San Francisco, CA on Friday, November 2, 2007. This briefing will be webcast and may be accessed by visiting the Events page under the Investors section of the Exelixis website (http://www.exelixis.com). An audio replay of the webcast will also be available until 8:59 PM PT/11:59 PM ET on December 2, 2007. To access this replay, participants may dial 1-888-286-8010 (domestic) or 1-617-801-6888 (international) and use passcode 98351402.

The results of the XL784 phase 2 trial meet the criteria for submission of the compound to GlaxoSmithKline (GSK) for evaluation under the product development and commercialization agreement between Exelixis and GSK. Pursuant to the agreement, GSK has the option, subject to criteria specified in the agreement, to elect to develop and commercialize up to three compounds in Exelixis' product pipeline from among XL784, XL880, XL184, XL820, XL999, XL844, XL228, XL281 and XL418. Exelixis expects to submit the data package to GSK by the end of October, after which GSK will have 90 days to review the data package and determine if it will select the compound for further clinical development and commercialization.

XL784 is also part of Exelixis' clinical development financing arrangement with Symphony Evolution, Inc. (SEI). In 2005, Exelixis licensed three of its compounds, XL784, XL647 and XL999, to SEI in return for $80 million for the clinical development of these compounds and an exclusive option to reacquire the compounds from SEI's investors at a specified purchase price. Exelixis is primarily responsible for the development of these compounds in accordance with specified development plans and related development budgets.

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