Navigation Links
Exelixis Reports Encouraging Phase 1 Data for XL184 at ASCO
Date:6/1/2008

100%, with 53% of evaluable MTC patients (9 of 17) experiencing partial responses. With a single exception, all of the evaluated MTC patients had reductions in the MTC-associated plasma markers calcitonin and carcinoembryonic antigen. Most of the MTC patients in the trial had previously failed other treatments, including tyrosine kinase inhibitors with anti-RET activity (e.g., vandetanib, sorafenib, motesanib), chemotherapeutics, immunotherapy, radioactive iodine, and radiotherapy.

"Patients with medullary thyroid cancer are a highly underserved population as there is no active approved therapy available at this time. Targeted therapeutics, such as dual inhibitors of RET and VEGFR2, are the first compounds showing activity in this disease. The phase 1 results of XL184, the first such molecule in this class also to inhibit the oncogenic MET receptor, were reported today by Drs. Salgia and Kurzrock, and are remarkable, both in terms of the high frequency of responses and how rapidly they occur," said Steven I. Sherman, MD, Chair and Professor, Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas M.D. Anderson Cancer Center, Houston, Texas. "I am looking forward to the phase 3 trial of XL184 in this indication and believe that studies like this will importantly advance the care of patients with medullary thyroid cancer."

The data indicate that XL184 was generally well-tolerated at the MTD of 175 mg QD (capsule). Adverse events related to study drug included diarrhea, nausea, fatigue, mucositis, anorexia, elevation of liver enzymes, hypertension, vomiting, hair hypopigmentation, and palmar-plantar erythema. Dose-limiting toxicities included palmar-plantar erythema, elevation of liver enzymes, lipase elevation, and mucositis.

Pharmacokinetic analyses indicate that the half-life of XL184 was approximately 100 hours (range 59-136 hours), with exposure at the MTD exceeding that required for efficacy in preclinical models. Pharma
'/>"/>

SOURCE Exelixis, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. GlaxoSmithKline Accelerates Review of Exelixis XL880
2. Exelixis Announces September 5 Webcast of Its 2007 IASLC Investor and Analyst Briefing
3. Exelixis Reports Top-Line Results of the Phase 2 Trial of XL784 in Patients With Proteinuria Associated With Diabetic Nephropathy
4. Updated Phase 1 Data for Exelixis XL184 Demonstrate Pharmacodynamic and Clinical Anti-Tumor Activity
5. Exelixis Reports XL647 Clinical Data at AACR-NCI-EORTC Conference
6. Interim Phase 2 Data for Exelixis XL880 Show Anti-Tumor Activity in Papillary Renal Cell Cancer
7. Phase 2 Trial Results for Exelixis XL784 Presented at the 2007 American Society of Nephrology Conference
8. Exelixis Presents Encouraging Phase 1 Data For XL019, A Novel Selective Inhibitor of JAK2
9. Exelixis Initiates Phase 1/2 Trial of XL184 in Patients With Non-Small Cell Lung Cancer
10. Exelixis Announces First Quarter 2008 Financial Results
11. Exelixis Reports Positive Clinical Pharmacodynamics Data for PI3K/mTOR Inhibitor XL765 at ASCO
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... and Markets ( http://www.researchandmarkets.com/research/zkkg9q/blood_processing ) has announced the addition of ... Business Report" report to their offering. The ... Canada , Japan , ... Latin America , and Rest of World. Annual estimates ... Also, a seven-year historic analysis is provided for these markets. ...
(Date:6/2/2015)... June 02, 2015 Research and Markets ( http://www.researchandmarkets.com/research/sn8mlw/picture_archiving ... and Communication Systems (PACS) - Global Strategic Business Report" ... comprehensive analytics for the US, Canada , ... Asia-Pacific , Latin America ... forecasts are provided for the period 2014 through 2020. Also, ...
(Date:6/2/2015)... June 2, 2015 Today the Council ... 150 major food companies, retailers, and human and ... on Antibiotic Stewardship. CSTE is committed to supporting ... detect resistant strains, preserve the efficacy of our ... infections. CSTE continues to serve as ...
Breaking Medicine Technology:Blood Processing Supplies and Equipment Market - Global Strategic Business Report 2015-2020 2Blood Processing Supplies and Equipment Market - Global Strategic Business Report 2015-2020 3Picture Archiving and Communication Systems (PACS) - Global Strategic Business Report 2015: User Demand Favors Integrated RIS/PACS Solutions 2
... 11 /PRNewswire-Asia-FirstCall/ -- ... ... var shortURL = ... so we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; ...
... WORCESTER, Mass., Oct. 11 Generex Biotechnology Corporation ... it has entered into a definitive agreement to ... Direct, LLC (" GMD ") of Lenexa, Kansas, ... specializing in direct-to-consumer diabetes supplies and medications ( ...
Cached Medicine Technology:China-Biotics to Attend BNP Paribas China Conference 2China-Biotics to Attend BNP Paribas China Conference 3China-Biotics to Attend BNP Paribas China Conference 4China-Biotics to Attend BNP Paribas China Conference 5China-Biotics to Attend BNP Paribas China Conference 6Generex Reaches Agreement to Acquire 51% Stake in Global Medical Direct, a Nationwide Durable Medical Equipment and Pharmaceutical Provider Specializing in Direct-to-Consumer Diabetes Supplies 2Generex Reaches Agreement to Acquire 51% Stake in Global Medical Direct, a Nationwide Durable Medical Equipment and Pharmaceutical Provider Specializing in Direct-to-Consumer Diabetes Supplies 3Generex Reaches Agreement to Acquire 51% Stake in Global Medical Direct, a Nationwide Durable Medical Equipment and Pharmaceutical Provider Specializing in Direct-to-Consumer Diabetes Supplies 4Generex Reaches Agreement to Acquire 51% Stake in Global Medical Direct, a Nationwide Durable Medical Equipment and Pharmaceutical Provider Specializing in Direct-to-Consumer Diabetes Supplies 5Generex Reaches Agreement to Acquire 51% Stake in Global Medical Direct, a Nationwide Durable Medical Equipment and Pharmaceutical Provider Specializing in Direct-to-Consumer Diabetes Supplies 6Generex Reaches Agreement to Acquire 51% Stake in Global Medical Direct, a Nationwide Durable Medical Equipment and Pharmaceutical Provider Specializing in Direct-to-Consumer Diabetes Supplies 7Generex Reaches Agreement to Acquire 51% Stake in Global Medical Direct, a Nationwide Durable Medical Equipment and Pharmaceutical Provider Specializing in Direct-to-Consumer Diabetes Supplies 8
(Date:6/2/2015)... Allred Dental, a dental office based in San Marcos ... along with a $100 off with free oral sedation special ... wisdom teeth can be impacted, meaning that they are enclosed ... partially break through the gum, causing pain and inflammation of ... people, as they do not have fully developed wisdom teeth ...
(Date:6/2/2015)... CA (PRWEB) June 02, 2015 ... system was released to public yesterday, and has ... Internet. HonestyFirstReviews.com's senior product reviewer Tiffany Hendricks has ... detailed review of the course on her website ... courses available for Internet marketers looking to hone ...
(Date:6/2/2015)... 02, 2015 On March 19th, 2015, ... in the Hall of Legends at Detroit’s Ford Field. ... speaker Herman Moore, the goal of the conference was ... today’s society, highlight the benefits of effective professional rehabilitation ... about the options that are available to them in ...
(Date:6/2/2015)... Milwaukee, WI (PRWEB) June 02, 2015 ... to announce Lauren Potter from the hit show Glee ... Down Syndrome Awareness Walk in Pleasant Prairie, WI. The ... services for families in Racine, Kenosha, and Walworth counties. ... to have Lauren join us for this important event," ...
(Date:6/2/2015)... June 02, 2015 The Horizon Blue ... today that its Walking and Wellness Challenge, held this ... Acer, has raised another $3,000 for the Boys & ... the challenge, recording 32,000 steps on her fitbit during ... Hotel & Golf Club in Galloway Township. , ...
Breaking Medicine News(10 mins):Health News:$100 Off Coupon for Wisdom Teeth Extractions Offered at Allred Dental 2Health News:100K Factory - Review of Aidan Booth and Steve Clayton's New IM System Published 2Health News:Rehabilitation Facility Graduate Shares Her Story at "Fighting Addiction Together" Conference 2Health News:Glee star Lauren Potter helps Down Syndrome Association of WI raise awareness, support 2Health News:LPGA’s Natalie Gulbis Raises an Additional $3,000 for the Boys & Girls Club of Atlantic City Through Horizon BCBSNJ’s Walking and Wellness Challenge 2
... centers through out India with collaboration from Histostem Inc.,// Histostem ... the largest public blood banks in the world with 55,000 ... various genetic treatments. ,The Apollo group of hospitals ... to provide stem cell therapy to patients. The team will ...
... to be effective in the treatment of cancer. Eleutherobin,// a ... to kill the cancer cells. ,Eleutherobin, which is produced ... corals, these toxins paralyze and kills the fish which come ... be 100 times stronger than taxol (drug which is widely ...
... have loss of vision and hence their eyes must ... ,Alzheimer’s disease affects the brain cells and slowly destroys ... memory, ability to reason, creative abilities and learning powers. ... much to be able to take notice of the ...
... signals like peptide signals reveals that they play// an ... with the conventional neurotransmitters., ,Investigations done by the ... use the chemical signals of 60 types of peptides ... the brain, control different forms of behavior that includes ...
... dark chocolate consumption to improved insulin sensitivity //and lowered ... chocolate a day for several weeks lowers blood pressure ... sensitivity in patients with hypertension., ,The team studied ... assigned 3.5 ounces of dark chocolate every day for ...
... were infected with HIV by 2004.// This puts the prevalence of ... Africa 's total population is 46.9 million. , ... higher than the estimate of 4.5 million given by the official ... ,The health department said that between 6.29 million and ...
Cached Medicine News:Health News:Eleutherobin From Coral Fights Cancer Cells 2Health News:Eleutherobin From Coral Fights Cancer Cells 3Health News:Over Six Million HIV Infected People In South Africa- Finds A Survey 2Health News:Over Six Million HIV Infected People In South Africa- Finds A Survey 3
... a low-price PC-based, 2-8-channel system for ... the retina and the optic nerve. ... operator monitor, printer, keyboard, mouse, bioelectrical ... electrical connections are easily to install. ...
... tool that allows to see the fundus ... stimulated. Besides it also includes the refractive ... between the pupil picture and the fundus ... is especially suited for animal research and ...
5 mm...
Cannula and irrigation extension. Overall Length 150 mm (6.25"). Light Curve....
Medicine Products: