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Everist Genomics Announces New Data on OncoDefender™- CRC Test for Predicting Recurrence Risk for Stage I and II Colorectal Cancer Patients
Date:6/3/2011

icity 55%). 'High-risk' patients had a significantly higher probability of recurrence within 36 months than 'low-risk' patients (PPV 0.51, NPV 0.73, HR 2.06 (95% CI: 1.10 to 3.86; p=0.020)). In contrast, the standard prognostic guidelines described by the NCCN Guidelines were unable to differentiate recurrence risk in this population (p=0.315).

Notably, the study found that Stage I colorectal cancer patients that were deemed 'high-risk' by the test recurred at a rate more than triple that for patients deemed 'low-risk'. "The updated data demonstrate that OncoDefender-CRC provides a more targeted stratification of patients, independent of other recognized prognostic variables, such as age, T-stage, grade, tumor location and lymphovascular invasion," said Lenehan.

Recent research in cancer genomics has shown that Stage I/II colorectal cancer tumors can differ greatly from other tumors that are classified in the same stage, indicating that some tumors present observable high-risk characteristics. Tumors that present such high-risk characteristics can be more than 20 times more likely to lead to a recurrence than tumors with low-risk characteristics. By more accurately identifying patients who have high-risk tumors, Lenehan said healthcare providers can more effectively target their treatment decisions, thereby potentially improving clinical outcomes.

"Recent literature shows that patients identified with high-risk early stage tumors benefit significantly from surgical removal of the tumor followed by adjuvant therapy," Lenehan said. "Until recently, however, physicians have not been equipped with prognostic tests that can accurately distinguish high-risk early stage tumors from low-risk tumors."

"The data from the OncoDefender-CRC study validate the effectiveness of this node-negative prognostic test in determining recurrence risk for this population, demonstrating the potential for optimizing post-op clinical management and patient stratif
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SOURCE Everist Genomics
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