Navigation Links
Everist Genomics Announces Acquisition of Angiologix, Inc.
Date:10/31/2011

ANN ARBOR, Mich., Oct. 31, 2011 /PRNewswire/ -- Everist Genomics, a rapidly growing personalized medicine company developing and commercializing innovative diagnostics and prognostics, announced today that it has successfully completed acquisition of 100% of the shares of Angiologix, Inc., the developer of the AngioDefender™ diagnostic device for assessing endothelial function.  Endothelial cell dysfunction is a key biomarker of early-stage atherosclerosis and CVD; it is also the earliest detectable sign of atherosclerosis. (1)

(Photo: http://photos.prnewswire.com/prnh/20111031/NY96250 )

(Logo: http://photos.prnewswire.com/prnh/20110110/NY26865LOGO)

AngioDefender is a highly accurate and low-cost tool designed to allow physicians to assess endothelial function -- a key indicator of blood vessel health.  Clinical syndromes such as stable and unstable angina, acute myocardial infarction, claudication, and stroke relate, in part, to a loss of endothelial control of vascular tone, thrombosis, and the composition of the vascular wall. (2) Such a tool could aid in the diagnosis of early stage atherosclerosis and cardiovascular disease (CVD) in asymptomatic patients.  Clinical studies (3) show that pharmacological and life style interventions are effective in treating endothelial dysfunction; these interventions are also efficacious in treating CVD:Intervention/TreatmentEffect on Endothelial FunctionEffect on CVD EventsLipid-lowering therapyBeneficial

BeneficialSmoking cessationBeneficial

BeneficialExerciseBeneficial

BeneficialACE Inhibitors

Beneficial

BeneficialAngiotensin receptor blockers

Beneficial

BeneficialN-3 fatty acids

Beneficial

BeneficialGlycemic control in diabetes mellitus

Beneficial

BeneficialThe endothelium, a thin layer of cells that line the walls of every blood vessel, is essential to ensuring that blood flows properly throughout the body.  Over time, the effects of high blood pressure, cholesterol, stress, alcohol, smoking and genetics can damage endothelial cells, preventing them from performing their vital functions.  Eventually, this damage to the endothelial cells will result in accumulation of fatty deposits called plaque that can rupture or have their caps shear off, causing clots that lead to heart attacks. If endothelial dysfunction is detected early enough, interventions like risk factor modification and drug therapy may improve prognosis. (4)

"The clinical evidence of an association between endothelial dysfunction and atherosclerosis and CVD is very strong," said Prasad Sunkara, Ph.D., Chief Executive Officer of Everist Genomics. "By providing an accurate assessment of endothelial function, AngioDefender may help physicians and patients to make treatment decisions aimed at reducing the risk of these serious conditions."

Subject to securing the required regulatory approvals, Everist Genomics will commercialize AngioDefender globally, starting in Europe and India during the first quarter of 2012.The current 'gold standard' for assessing endothelial function utilizes ultrasound to perform a costly and complex assessment of flow mediated dilation (FMD) of the brachial artery (BA).  This type of assessment has several major limitations, such as requiring the use of expensive ultrasound equipment, a specialized ultrasound probe and a highly-trained technician. Due to these limitations, along with the time required to perform ultrasound based measurement of FMD, its use has been confined to research applications.  

AngioDefender overcomes these limitations by utilizing a patented noninvasive technology for assessing endothelial dysfunction that produces consistent results regardless of operator differences.  AngioDefender assesses endothelial dysfunction by measuring changes in volume of a segment of the BA in response to a temporary occlusion of the artery.  The AngioDefender test is much easier to perform than brachial artery ultrasound--the entire test can be conducted and results reported in about 15 minutes by a physician or technician--and the device will achieve a cost-savings of more than 80% when compared with brachial artery ultrasound.  Importantly, several multinational studies have shown AngioDefender to correlate with Brachial Artery Ultrasound in measuring FMD. (5)

"Our AngioDefender device has the potential to be a major advance in diagnosing and treating early stage atherosclerosis and CVD," said Prasad Sunkara, Ph.D., Chief Executive Officer of Everist Genomics.  "AngioDefender has been successfully validated in several multinational studies demonstrating its accuracy and reliability in assessing endothelial function through measurement of FMD. This innovative diagnostic reflects Everist Genomics commitment to developing and commercializing high-value prognostic testing technologies that have the potential to create substantial improvements in clinical outcomes while also reducing healthcare costs," he added.

Further describing the financial benefits of AngioDefender, Dr. Sunkara explained that if the device resulted in only a 1% reduction in the number of people developing advanced CVD, the annual savings would be enough to recover the total cost of performing the test on 20 million Americans every year and would generate an additional $1.03 billion in annual cost savings to the healthcare system.  

"The medical community has been struggling for years to find diagnostic and treatment solutions for cardiovascular disease that improve patient outcomes in a way that is fiscally sustainable," said Dr. Sunkara. "By identifying the disease in its earliest stage, when it is most responsive to therapy and life-style modification, tests that assess endothelial function may provide the ability to finally achieve that balance."

In addition to identifying patients with early stage cardiovascular disease, AngioDefender might prove useful to monitor disease progression and effectiveness of cardiovascular therapies, enabling personalized dosage and treatment regimens.  The test would be applicable to any patient, regardless of age, gender, ethnicity or pre-existing conditions. The test reports 25 elements of the patient record and CVD test parameters for each patient to a computer or mobile computing device for use by physicians.

About Everist GenomicsEverist Genomics is a prognostics company focused on developing gene-based molecular assays for the prediction of cancer recurrence and proprietary point-of-care equipment for the evaluation and management of cardiovascular disease. Using its patented Evolver™ technology platform, Everist Genomics is successfully developing and commercializing entirely new classes of patent-protected molecular biomarkers and sensor technologies which employ proprietary equipment, devices and software to help physicians make individualized treatment and drug prescribing decisions.  The privately owned company is located in Ann Arbor, Michigan.  For more information, please visit www.everistgenomics.com.

(1) Journal of the American College of Cardiology Vol. 42, No. 7, 2003; The Clinical Implications of Endothelial Dysfunction; Michael E. Widlansky, MD, Noyan Gokce, MD, FACC, John F. Keaney, JR, MD, FACC, Joseph A. Vita, MD, FACC; Boston, Massachusetts

(2) Journal of the American College of Cardiology Vol. 42, No. 7, 2003; The Clinical Implications of Endothelial Dysfunction; Michael E. Widlansky, MD, Noyan Gokce, MD, FACC, John F. Keaney, JR, MD, FACC, Joseph A. Vita, MD, FACC; Boston, Massachusetts

(3) Sources:  Weight of evidence indicates an improvement  Sources: Journal of the American College of Cardiology Vol. 42, No. 7, 2003; The Clinical Implications of Endothelial Dysfunction; Michael E. Widlansky, MD, Noyan Gokce, MD, FACC, John F. Keaney, JR, MD, FACC, Joseph A. Vita, MD, FACC; Boston, Massachusetts

(4) http://atvb.ahajournals.org/content/23/2/168.full  

(5) Moscow Medical Academy. Clinical evaluation showed strong correlation (R=0.84) between %FMD by AngioDefender with Brachial Artery Ultrasound; Medanta, Medical City. Clinical evaluation showed high degree of correlation (R=0.77) between %FMD by AngioDefender with Brachial Artery Ultrasound.


'/>"/>

SOURCE Everist Genomics
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Everist Genomics Announces New Data on OncoDefender™- CRC Test for Predicting Recurrence Risk for Stage I and II Colorectal Cancer Patients
2. Everist Genomics Announces Worldwide Availability of OncoDefender™-CRC
3. Genetics Squared Changes Name To Everist Genomics
4. Synthetic Genomics Vaccines, Inc. Hires Vaccine Executive Sammy J. Farah as President
5. Cancer Game Changers: Genomics, Smarter Medicine, Care Coordination Comprise Medcos Advanced Oncology Solutions™
6. Signal Genetics Announces Commercialization Partnership with NeoGenomics Laboratories for Multiple Myeloma Gene Expression Test
7. CrystalGenomics Completes Phase I MAD Study of its Novel Antibiotic Candidate CG400549, and Prepares for Phase II Clinical Study
8. Rosetta Genomics Announces Issuance of Additional U.S. Patent
9. WaferGen Appoints World-Renowned Clinical Genomics Cancer Researcher Dr. Arul M. Chinnaiyan to Scientific Advisory Board
10. NeoGenomics Awarded $374,000 in R&D Grants from the US Government
11. NeoGenomics Schedules its Q3 2010 Earnings Release for October 28, 2010
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... 2016 Roche (SIX: RO, ROG; OTCQX: RHHBY) ... Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated testing ... With this clearance, Roche is the first IVD company ... for sepsis risk assessment and management. PCT ... PCT levels in blood can aid clinicians in assessing ...
(Date:6/23/2016)... 23, 2016 Bracket , a leading clinical ... generation clinical outcomes platform, Bracket eCOA (SM) 6.0, at ... 26 – 30, 2016 in Philadelphia , ... Outcome Assessment product of its kind to fully integrate with ... Bracket eCOA 6.0 is a flexible platform for electronic clinical ...
(Date:6/23/2016)... , June 23, 2016 ... Oticon , industry leaders in advanced ... launch of Oticon Opn ™, the world,s first ... of possibilities for IoT devices.      (Photo: ... Oticon introduces a number of ,world firsts,: ...
Breaking Medicine Technology:
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Pixel Film ... Pro X. , "Film editors can give their videos a whole new perspective by ... Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 ...
(Date:6/26/2016)... ... 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to ... app. The fitness app plans to fix the two major problems leading the fitness industry ... fits all type program , They don’t eliminate all the reasons people quit ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from ... at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center ... care topics including advance care planning, healthcare costs and patient and family engagement. ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... First ... United States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell ... facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive ...
Breaking Medicine News(10 mins):