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Everist Genomics Announces Acquisition of Angiologix, Inc.
Date:10/31/2011

ANN ARBOR, Mich., Oct. 31, 2011 /PRNewswire/ -- Everist Genomics, a rapidly growing personalized medicine company developing and commercializing innovative diagnostics and prognostics, announced today that it has successfully completed acquisition of 100% of the shares of Angiologix, Inc., the developer of the AngioDefender™ diagnostic device for assessing endothelial function.  Endothelial cell dysfunction is a key biomarker of early-stage atherosclerosis and CVD; it is also the earliest detectable sign of atherosclerosis. (1)

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AngioDefender is a highly accurate and low-cost tool designed to allow physicians to assess endothelial function -- a key indicator of blood vessel health.  Clinical syndromes such as stable and unstable angina, acute myocardial infarction, claudication, and stroke relate, in part, to a loss of endothelial control of vascular tone, thrombosis, and the composition of the vascular wall. (2) Such a tool could aid in the diagnosis of early stage atherosclerosis and cardiovascular disease (CVD) in asymptomatic patients.  Clinical studies (3) show that pharmacological and life style interventions are effective in treating endothelial dysfunction; these interventions are also efficacious in treating CVD:Intervention/TreatmentEffect on Endothelial FunctionEffect on CVD EventsLipid-lowering therapyBeneficial

BeneficialSmoking cessationBeneficial

BeneficialExerciseBeneficial

BeneficialACE Inhibitors

Beneficial

BeneficialAngiotensin receptor blockers

Beneficial

BeneficialN-3 fatty acids

Beneficial

BeneficialGlycemic control in diabetes mellitus

Beneficial

BeneficialThe endothelium, a thin layer of cells that line the walls of every blood vessel, is
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