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Eutropics Pharmaceuticals signs $1.5M NCI/SBIR contract to develop companion diagnostic for guiding Multiple Myeloma treatments
Date:9/20/2012

Eutropics to put a validated test in the hands of people who will benefit from it," said Michael Cardone, Chief Executive Officer at Eutropics.

Collaborations between Eutropics and M.D. Anderson Cancer Center, the University of Massachusetts Medical School, The Mayo Clinic, TGen Corporation, the DFCI, and several pharmaceutical and biotechnology partners are currently underway to support the rapid clinical development of this technology. Funds from this contract will support validation studies leading to commercialization.  Eutropics will develop strategic alliances with pharmaceutical and diagnostic companies to distribute the test.

About BH3 profiling   
In the area of cancer treatment, understanding, detecting, and controlling mitochondrial function is a critical area of focus. Mitochondria represent a critical node for understanding how to selectively kill cancer cells while preserving non-cancer cells. BH3 profiling is used to determine if the mitochondria in a cancer cell are preset to commit a cell to death in response to upstream signaling.

This allows predicting responses to therapies that either initiate signals upstream of the mitochondria or directly target the apoptosis regulating proteins at the mitochondrial surface.  The BH3 profiling assay has proven to be highly effective at identifying when certain apoptosis inducing therapies will or will not be effective in cancer patients.

About Eutropics Pharmaceuticals   
Eutropics Pharmaceuticals is dedicated to becoming a leader in personalized cancer therapy. The company is employing proprietary BH3-profiling biomarker technology to replace empirical treatment paradigms with more targeted therapy. The biomarker provides a unique understanding of cancer cells that is important in the pre-clinical development of experimental drugs and will be important in the later stages of their development, including the developm
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