Navigation Links
Eutropics Pharmaceuticals signs $1.5M NCI/SBIR contract to develop companion diagnostic for guiding Multiple Myeloma treatments
Date:9/20/2012

CAMBRIDGE, Mass., Sept. 20, 2012 /PRNewswire/ -- Eutropics Pharmaceuticals has signed a $1.5M phase 2 contract with the National Cancer Institute Small Business Initiative Research (NCI-SBIR) to commercially develop  its proprietary diagnostic assay for personalized medicine approaches in Multiple Myeloma (MM) patient management. The award follows a highly successful phase 1 contract that demonstrated the commercial potential for the core technology called BH3 profiling.  Eutropics holds an exclusive license for this asset from equity partner, the Dana Farber Cancer Institute (DFCI).

(Logo: http://photos.prnewswire.com/prnh/20120920/NE78229LOGO )

The BH3 profiling technology provides a biomarker/diagnostic to help guide the use of several approved therapies for MM, as well as other cancer indications, and is being advanced as a companion test for experimental therapies currently in development. The biomarker provides a unique, functional understanding of cancer cells that indicates if they are capable of responding to certain treatments. This understanding will be particularly important in deciding when to use, or to avoid, certain therapies in newly diagnosed or relapsed/refractory MM patients. Such an approach will allow for the identification of the best treatment option for each individual patient.  Eutropics' approach is consistent with the July 2011 roadmap announcement made by the FDA calling for companion tests that will improve treatment efficacies by selecting appropriate use of targeted oncology therapies based on predictive molecular discriminators.

"Our physician colleagues, thought leaders in the area of treating multiple myeloma, have clearly indicated the need for new tools that will guide treatment. The NCI has confirmed our belief that this technology will provide such a tool and with this contract has requisitioned Eutropics to put a validated test in the hands of people who will benefit from it," said Michael Cardone, Chief Executive Officer at Eutropics.

Collaborations between Eutropics and M.D. Anderson Cancer Center, the University of Massachusetts Medical School, The Mayo Clinic, TGen Corporation, the DFCI, and several pharmaceutical and biotechnology partners are currently underway to support the rapid clinical development of this technology. Funds from this contract will support validation studies leading to commercialization.  Eutropics will develop strategic alliances with pharmaceutical and diagnostic companies to distribute the test.

About BH3 profiling   
In the area of cancer treatment, understanding, detecting, and controlling mitochondrial function is a critical area of focus. Mitochondria represent a critical node for understanding how to selectively kill cancer cells while preserving non-cancer cells. BH3 profiling is used to determine if the mitochondria in a cancer cell are preset to commit a cell to death in response to upstream signaling.

This allows predicting responses to therapies that either initiate signals upstream of the mitochondria or directly target the apoptosis regulating proteins at the mitochondrial surface.  The BH3 profiling assay has proven to be highly effective at identifying when certain apoptosis inducing therapies will or will not be effective in cancer patients.

About Eutropics Pharmaceuticals   
Eutropics Pharmaceuticals is dedicated to becoming a leader in personalized cancer therapy. The company is employing proprietary BH3-profiling biomarker technology to replace empirical treatment paradigms with more targeted therapy. The biomarker provides a unique understanding of cancer cells that is important in the pre-clinical development of experimental drugs and will be important in the later stages of their development, including the development of the company's first in class anti-cancer therapeutic compound. The BH3-profiling technology was invented by Stan Korsmyer and Anthony Letai at DFCI.  Eutropics holds an exclusive license for commercializing this assay. The company's operations in Cambridge, MA, are supported by private investors, the NCI, and a loan from the State of Massachusetts Life Sciences Center.


'/>"/>
SOURCE Eutropics Pharmaceuticals
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Eutropics Pharmaceuticals awarded NCI contract to develop companion diagnostic for guiding AML treatments
2. Savient Pharmaceuticals to Hold First Quarter 2012 Financial Results Conference Call on Wednesday, May 9, 2012
3. Auxilium Pharmaceuticals to Present at the Deutsche Bank 37th Annual Healthcare Conference
4. Nouveau Life Pharmaceuticals (HRID) Contracts with U.S. Manufacturer to Produce New Female Supplement
5. BioElectronics Survey Indicates a Five-Fold Superior Pain Relief Compared to OTC Pharmaceuticals
6. Icahn Issues Statement Regarding Amylin Pharmaceuticals
7. Almost 50 Percent of the Glaucoma Patient Population Remains Untreated, Signifying a Vast Market for Glaucoma Pharmaceuticals, Finds Frost & Sullivan
8. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
9. Onyx Pharmaceuticals Announces FDA Advisory Committee to Review Carfilzomib for the Treatment of Patients with Relapsed and Refractory Multiple Myeloma
10. Jazz Pharmaceuticals Announces First Quarter 2012 Financial Results Conference Call On May 8, 2012
11. Inovio Pharmaceuticals Granted U.S. Patent Protection for Synthetic Vaccine for Cervical Dysplasia and Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)...  Memorial Hermann Health System has teamed up with ... bring a one-of-a-kind experience to pediatric patients at ... as 360-degree video and Google Cardboard, Howard was able ... giving the patients and their families an unexpected, and ... on video . Memorial Hermann IRONMAN ...
(Date:2/12/2016)... Feb. 12, 2016  Aralez Pharmaceuticals Inc. (Nasdaq: ... the Company will ring the Nasdaq Closing Bell at ... York at 4:00 p.m. ET on Tuesday, ... Adrian Adams , will perform the ... to 4:00 p.m. ET.  A live webcast will be ...
(Date:2/12/2016)... 2016 --> ... Inflammation Global Clinical Trials Review, H2, 2015 provides ... clinical trials landscape along with top level data ... (G7 & E7), Trial Status, Trial Phase, Sponsor ... companies involved and enlists all trials (Trial title, ...
Breaking Medicine Technology:
(Date:2/12/2016)... ... ... The law firm of Morrow, Morrow, Ryan & Bassett is offering scholarships to ... to encourage applicants to pursue a degree in their field of study and upon ... “We have available jobs in St. Landry and Evangeline Parishes that can be filled ...
(Date:2/12/2016)... Falls Church, VA (PRWEB) , ... February 12, ... ... in Store?, Feb. 29, 2016 — 1:30 p.m. – 3:00 p.m. EST, ... burner issue in the life cycle of pharmaceutical products, garnering increased attention from ...
(Date:2/12/2016)... ... February 12, 2016 , ... T.E.N., a ... closed for the ISE Southeast Awards 2016. Finalists and winners of the ISE® ... Southeast Executive Forum and Awards Gala on March 15, 2016 at the Westin ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Fisher House Foundation ... Mayor John J. Lee, Nevada Military Support Alliance president Scott Bensing, and Peggy Kearns ... the VA Southern Nevada Healthcare System. This will be the first Fisher House ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Erlanger Agency ... the greater Columbus, OH area. The latest campaign focuses on the fight against breast ... Donations are now being accepted here . , Carmen is a loving single ...
Breaking Medicine News(10 mins):