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Eutropics Pharmaceuticals awarded NCI contract to develop companion diagnostic for guiding AML treatments
Date:9/18/2012

CAMBRIDGE, Mass., Sept. 18, 2012 /PRNewswire/ -- Eutropics Pharmaceuticals has signed a contract with the National Cancer Institute through the Small Business Initiative Research (NCI-SBIR) program to develop its proprietary BH3 profiling diagnostic assay for personalized medicine approaches in Acute Myelogenous Leukemia (AML) patient management. The assay provides a biomarker/ diagnostic to help guide the use of several approved therapies for multiple cancer indications and is being tested as a companion test for experimental therapies currently in development. The biomarker provides a unique, functional understanding of cancer cells that indicates if they are capable of responding to certain treatments. This understanding will be important in deciding when to use, or to avoid certain therapies in treating patients. The work funded by this contract will validate early results that indicate the predictive utility of the assay. The technology also provides insights that are useful in the pre-clinical development of new therapeutics.  Eutropics is currently working with several leading cancer centers to validate the clinical utility of the assay and expand these studies into clinical trials with pharmaceutical partners in the next stage of the study.

The use of BH3 profiling as a novel diagnostic approach in personalized medicine is consistent with the July 2011 roadmap announcement made by the FDA calling for companion tests that will improve treatment efficacies by selecting appropriate use of targeted oncology therapies based on predictive molecular discriminators.  "This award confirms our approach to providing such a test and positions Eutropics to move the technology forward, empowering oncologists with valuable information for providing the most effective care to their patients," said Michael Cardone, Chief Executive Officer at Eutropics.

"There is a very good likelihood that this BH3 profiling technology will pro
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SOURCE Eutropics Pharmaceuticals
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