Navigation Links
Eutropics Pharmaceuticals awarded NCI contract to develop companion diagnostic for guiding AML treatments
Date:9/18/2012

CAMBRIDGE, Mass., Sept. 18, 2012 /PRNewswire/ -- Eutropics Pharmaceuticals has signed a contract with the National Cancer Institute through the Small Business Initiative Research (NCI-SBIR) program to develop its proprietary BH3 profiling diagnostic assay for personalized medicine approaches in Acute Myelogenous Leukemia (AML) patient management. The assay provides a biomarker/ diagnostic to help guide the use of several approved therapies for multiple cancer indications and is being tested as a companion test for experimental therapies currently in development. The biomarker provides a unique, functional understanding of cancer cells that indicates if they are capable of responding to certain treatments. This understanding will be important in deciding when to use, or to avoid certain therapies in treating patients. The work funded by this contract will validate early results that indicate the predictive utility of the assay. The technology also provides insights that are useful in the pre-clinical development of new therapeutics.  Eutropics is currently working with several leading cancer centers to validate the clinical utility of the assay and expand these studies into clinical trials with pharmaceutical partners in the next stage of the study.

The use of BH3 profiling as a novel diagnostic approach in personalized medicine is consistent with the July 2011 roadmap announcement made by the FDA calling for companion tests that will improve treatment efficacies by selecting appropriate use of targeted oncology therapies based on predictive molecular discriminators.  "This award confirms our approach to providing such a test and positions Eutropics to move the technology forward, empowering oncologists with valuable information for providing the most effective care to their patients," said Michael Cardone, Chief Executive Officer at Eutropics.

"There is a very good likelihood that this BH3 profiling technology will provide an important guiding tool for treating AML," said Dr. Michael Andreeff, Chief of Molecular Hematology at MD Anderson Cancer Center and scientific advisor to Eutropics. "We are all looking forward to its validation in the clinical studies proposed in this contract," he added.

About BH3 profiling
In the area of cancer treatment, understanding, detecting, and controlling mitochondrial function is a critical area of focus. It has become clear over the past twenty years of apoptosis research that events occurring at the mitochondrial surface determine the ability of the cancer cell to respond to apoptosis-inducing cancer therapy. Mitochondria therefore represent a critical node for understanding how to selectively kill cancer cells while preserving non-cancer cells. BH3 profiling can be used to determine if the mitochondria in a cancer cell are preset to commit a cell to death in response to upstream signaling. This understanding identifies if a cancer cell will or will not respond to apoptosis signals. By this understanding, one can predict responses to therapies that either initiate signals upstream of the mitochondria or directly target proteins which regulate apoptosis at the mitochondrial surface.  To date, the BH3 profiling assay has proven highly effective at identifying when certain apoptosis-inducing therapies will or will not be effective, both in cancer cells in vitro and in cancer patients.

About Eutropics Pharmaceuticals
Eutropics Pharmaceuticals is using a new biomarker/companion diagnostic to help guide the development and use of cancer therapies.  The biomarker provides a unique understanding of cancer cells that is important in the pre-clinical development of experimental drugs and will be important in the later stages of their development, including the development of Eutropics' first in class anti-cancer therapeutic compound that targets the apoptosis regulating protein Mcl-1. BH3 profiling also has utility as a predictive diagnostic assay for therapies currently in use to treat multiple myeloma, AML, and CLL, and will have wider oncology applications. The BH3 profiling technology seeks to displace current treatment paradigms by developing predictive clinical tests that may be used to identify when a particular therapy is or is not likely to be effective in a particular patient. This personalized medicine approach will result in more effective treatments and reduce unnecessary suffering.  The company is supported by private investors, grants and contracts from the National Cancer Institute (NCI), and funding from the State of Massachusetts.


'/>"/>
SOURCE Eutropics Pharmaceuticals
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Savient Pharmaceuticals to Hold First Quarter 2012 Financial Results Conference Call on Wednesday, May 9, 2012
2. Auxilium Pharmaceuticals to Present at the Deutsche Bank 37th Annual Healthcare Conference
3. Nouveau Life Pharmaceuticals (HRID) Contracts with U.S. Manufacturer to Produce New Female Supplement
4. BioElectronics Survey Indicates a Five-Fold Superior Pain Relief Compared to OTC Pharmaceuticals
5. Icahn Issues Statement Regarding Amylin Pharmaceuticals
6. Almost 50 Percent of the Glaucoma Patient Population Remains Untreated, Signifying a Vast Market for Glaucoma Pharmaceuticals, Finds Frost & Sullivan
7. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
8. Onyx Pharmaceuticals Announces FDA Advisory Committee to Review Carfilzomib for the Treatment of Patients with Relapsed and Refractory Multiple Myeloma
9. Jazz Pharmaceuticals Announces First Quarter 2012 Financial Results Conference Call On May 8, 2012
10. Inovio Pharmaceuticals Granted U.S. Patent Protection for Synthetic Vaccine for Cervical Dysplasia and Cancer
11. Avanir Pharmaceuticals To Present at Three Conferences In May
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... 11, 2016 The primary goal of this ... patterns on the usage of liquid biopsy. Key information ... - Timeframe of liquid biopsy adoption amidst future ... Evs—by organization type - Sample inflow to conduct liquid ... stool, serum, and so on. - Correlation analysis of ...
(Date:2/11/2016)... OAKLAND, Calif. , Feb. 11, 2016  Walgreens ... stores across 39 states and Washington, D.C. ... in a move that was commended by shareholder advocacy organization ... President at As You Sow. "Many people hold on to ... options, which can have tragic consequences." --> ...
(Date:2/11/2016)...  MiMedx Group, Inc. (NASDAQ: MDXG ), the ... other birth tissues, human skin and bone, and patent-protected ... products and therapies, announced today that it will present ... in New York , NY.  Parker ... Senken , Chief Financial Officer and Chris Cashman ...
Breaking Medicine Technology:
(Date:2/13/2016)... Montreal, Canada (PRWEB) , ... February 13, 2016 , ... ... best foot forward. They’ll groom themselves to perfection, go out of their way to ... their date – just take a look at any online dating profile. , ...
(Date:2/12/2016)... ... February 12, 2016 , ... According to an article published ... for a significant portion of hernia repairs throughout the United States. Commenting on this ... Center notes that this trend has not only been expected, but it seems to ...
(Date:2/12/2016)... ... February 12, 2016 , ... The law firm of Morrow, Morrow, Ryan & ... purpose of these scholarships is to encourage applicants to pursue a degree in their ... these two parishes. , “We have available jobs in St. Landry and Evangeline ...
(Date:2/12/2016)... , ... February 12, 2016 , ... ... devoted exclusively to funding innovative lymphoma research and serving the lymphoma community through ... over 250 members of South Florida’s philanthropic community at its 10th anniversary Fashion ...
(Date:2/12/2016)... Falls Church, VA (PRWEB) , ... February 12, ... ... in Store?, Feb. 29, 2016 — 1:30 p.m. – 3:00 p.m. EST, ... burner issue in the life cycle of pharmaceutical products, garnering increased attention from ...
Breaking Medicine News(10 mins):