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European patient registry in venous thromboembolism (VTE) - PREFER in VTE - enrols first patient
Date:2/6/2013

ut AF

AF is an abnormal rhythm of the heart.[10] The heart has four chambers - two atria and two ventricles.[11] The atria pump blood into the ventricles and the right ventricle pumps blood around the body; they therefore have to work in sequence for the heart to pump blood most effectively with each heartbeat.[11]

A normal heart pumps blood with a regular rhythm - it can beat quickly or slowly but the interval between beats is the same.[11] When a patient suffers from AF, numerous electrical pulses that fire from the heart muscles in the atria override the normal controlling 'timer' in the heart.[11] When this happens, the atria contract rapidly, but only partially, and as a result pump blood less effectively.[11]

Consequently, blood is not pumped effectively from the atria, which may cause the blood to stagnate and form clots. These blood clots can break off and travel through the blood stream e.g. to the brain, where they have the potential to cause a stroke.[11]

About Edoxaban

Edoxaban is licensed only in Japan for the prevention of venous thromboembolism (VTE) after major orthopaedic surgery, under the brand name Lixiana®.

Elsewhere, including Europe and the U.S., edoxaban is currently in phase 3 of clinical development and has not yet been approved. Daiichi Sankyo continues to develop edoxaban at a global level as a potential new treatment for the prevention of SEE in patients with NVAF and for the treatment and prevention of recurrence of VTE in patients with acute DVT and/or PE.

About Daiichi Sankyo

The Daiichi Sankyo Group is dedicated to the creation and supply of innovative pharmaceutical products to address the diversified, unmet medical needs of patients in both mature and emerging markets. While maintaining its portfolio of marketed pharmaceuticals f
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SOURCE Daiichi Sankyo Europe GmbH
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