Navigation Links
Etirinotecan Pegol (NKTR-102) Passes Interim Efficacy Analysis for BEACON Pivotal Phase 3 Clinical Study in Patients with Metastatic Breast Cancer
Date:1/14/2014

SAN FRANCISCO, Jan. 14, 2014 /PRNewswire/ -- Nektar Therapeutics (NASDAQ: NKTR) announced today that the Independent Data Monitoring Committee (DMC) created to provide safety oversight for the Company's pivotal clinical study for etirinotecan pegol (NKTR-102) has recommended continuation of the BEACON phase 3 trial, based upon the completion of a planned interim efficacy analysis in accordance with the DMC charter.  The BEACON trial is evaluating NKTR-102 versus an agent of physician's choice for the treatment of locally recurrent or metastatic breast cancer, with a primary efficacy endpoint of overall survival. NKTR-102 is the first long-acting topoisomerase I-inhibitor designed to concentrate in tumor tissue, provide sustained tumor suppression throughout the entire chemotherapy cycle, and to reduce the peak exposures that are associated with toxicities of other cytotoxics.

The independent DMC performed the pre-defined interim efficacy analysis, which consisted of a review of ongoing efficacy and safety data, including 50% of patient events necessary to evaluate the primary endpoint of overall survival.  In August 2013, the BEACON study completed enrollment of 852 patients with advanced breast cancer whose disease has progressed following treatment with anthracycline, taxane and capecitabine therapies (ATC).

"While the results of BEACON remain blinded to Nektar, we are very pleased that the NKTR-102 trial has successfully passed this important interim efficacy analysis," said Howard Robin, President and CEO of Nektar Therapeutics.  "We expect final results from the study at the end of 2014 or early 2015, and if positive, we plan to submit filings in the U.S. and Europe in the second half of 2015. There is a high unmet need for new treatment options for patients with
'/>"/>

SOURCE Nektar Therapeutics
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Nektar Completes Enrollment in Phase 3 BEACON Study of Etirinotecan Pegol in Women With Metastatic Breast Cancer
2. Nektar Presents Target-Specific Biomarkers Being Assessed in Ongoing Phase 3 BEACON Study of Etirinotecan Pegol for the Treatment of Metastatic Breast Cancer at the 2013 American Society of Clinical Oncology Annual Meeting
3. Nektar Announces that FDA Grants Fast Track Designation to Etirinotecan Pegol (NKTR-102) for the Treatment of Metastatic Breast Cancer
4. Nektar Announces Initiation of Investigator-Sponsored Trial Evaluating Etirinotecan Pegol (NKTR-102) in Patients with Bevacizumab (Avastin)-resistant High-Grade Glioma
5. CAS REGISTRY(SM) surpasses 75 million small molecules
6. WuXi Manufacturing Facility Passes FDA Inspection
7. Tecfideras Patient Share at Three Months Postlaunch Surpasses That for Aubagio and Gilenya At the Same Stage of Their Launches
8. Emotivs Brainwear Technology To Track Cognitive Health Surpasses $1M Kickstarter Stretch Goal
9. The Leukemia & Lymphoma Society Co-Pay Assistance Fund Surpasses $200 Million
10. French Man with SynCardia Total Artificial Heart Surpasses Two Years of Support
11. NABPs .PHARMACY Proposal Passes Initial ICANN Evaluation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2015)... , Feb. 26, 2015  MEI Pharma, Inc. (Nasdaq: ... development of novel therapies for cancer, announced today that ... will present at the Cowen and Company 35 th ... 10:40 a.m. Eastern time from the Boston Marriott Copley Place. ... www.meipharma.com . A replay will be available approximately one ...
(Date:2/26/2015)... , Feb. 26, 2015 Ultrasound ... at the Clearwater Beach Hilton to provide the ... to plant reliability professionals from around the world. ... stellar collection of leaders in the field of ... demand for excellence continues with this year,s conference. ...
(Date:2/26/2015)... , Feb. 26, 2015   Coverall North ... franchised businesses, today celebrates 30 Years of Clean, a ... anniversary. Coverall started in 1985 as a ... and is now a leading global brand ... Coverall,s passion and mission have remained consistent: To promote ...
Breaking Medicine Technology:MEI Pharma to Present at Cowen and Company Health Care Conference 2MEI Pharma to Present at Cowen and Company Health Care Conference 3UE Systems Renowned "Ultrasound World" Conference Celebrates its 11th Year 2Coverall Celebrates 30 Years of Clean 2Coverall Celebrates 30 Years of Clean 3
(Date:2/27/2015)... 2015 The Hermitage has responded to ... violations that date back to 2012. The mitigation work ... soon as it was approved in the summer of ... the allegations we agreed to 100% mitigation at our ... Holding Company. , Barnes further added, "we were surprised ...
(Date:2/27/2015)... UAS LifeSciences, will showcase their new chewable adult ... March 6 to 8 in Anaheim, CA. ... down best tasting probiotic in the business, Adult Cubes. ... Vitamin C. This is a companion product to our ... Living’s Supplement Award and Taste for Life’s Essential Supplements ...
(Date:2/27/2015)... Park, Kansas (PRWEB) February 27, 2015 ... ( http://www.cdc.gov/datastatistics/2008/brainInjuries ), more than 38 million children ... States each year. As a result of ... reaching capacity maximizing their equipment and square footage ... suspended athletic equipment. , "Athletic ...
(Date:2/27/2015)... 2015 Leading up to the White ... PartnerTech Inc. President, Gary Bruce, joined with other ... for the TechAmerica DC Fly-In. This is a ... technology along with the opportunity to have a voice ... products, evidenced by their current projects with NanoLumens ...
(Date:2/27/2015)... Javon Bea Mercy Health System President ... and open to the public, is held the second ... Mall Food Court, 2500 Milton Ave. Monthly meetings include ... and an educational health-related presentation. Participants receive a free ... for Health. , March 10: Using exercise to feel ...
Breaking Medicine News(10 mins):Health News:Southern Vermont's Hermitage Club Announces Statement Regarding Vermont Attorney General Lawsuit for Permit Violations 2Health News:UAS LifeSciences to Launch UP4 Adult Cubes at Expo West 2Health News:Rise of Students Participating in Sports Creates Need for Preventative Maintenance to Gymnasium Equipment in Athletic Facilities 2Health News:Rise of Students Participating in Sports Creates Need for Preventative Maintenance to Gymnasium Equipment in Athletic Facilities 3Health News:PartnerTech Joins Technology Association of Georgia for TechAmerica DC Fly-In 2Health News:PartnerTech Joins Technology Association of Georgia for TechAmerica DC Fly-In 3
... is good for the heart. A recent study undertaken by Robert// ... School has found that by eating fish regularly, the risk ... a lower risk of cardiovascular problems. , ,The substance ... lean varieties such as salmon. The study used more than 3,000 ...
... A large new study reports that Vitamin E is unlikely ... the risk of heart attacks and stroke in older women. ... Pauling Institute at Oregon State University and an expert on ... to reduce the risk of heart and other serious degenerative ...
... age of 60 and above can have less back pain ... back supporting device and doing some special exercises. ,In ... said that the new specially weighed back support device can ... extensive improvements in strength for the women who had suffered ...
... Prayers can help heart patients in the recovery process ... // University Medical Centre. Researchers said cardiac patients using ... heart failure, post-procedural ischemia or heart attack,than those without ... to April 1998 with symptoms of acute coronary ischemia. ...
... and colleagues compared their Cell culture small pox vaccine// ... vaccine. Small pox vaccine currently used is a live, ... produces adverse effects in vaccinated, 15-42 develop serious or ... 2 people every million die because of this vaccine. ...
... of osteoporosis is useful, but changes in bone// mineral ... are anti-resorptive agents that prevent bone breakdown. ,For ... that enhances bone formation is preferable, and this is ... (PTH). However, the use of PTH is limited by ...
Cached Medicine News:Health News:The Benefits of Strontium in the treatment for Osteoporosis Questioned 2
... response roller-pumps, the REVOLUTION provides continuous ... field. Furthermore the dual pump system ... intra-articular pressure and flow rate. , ... controls, providing the surgeon with the ...
... Burner captures still images and full ... archives allows for multiple cases to ... unit provides software burned to every ... and editing. Compatible with DICOM and ...
The Sony DSR20-MD Grade Digital Video Player/Recorder represents a giant leap in digital technology. , ,This equipment is intended to be used by physicians who teach or present medical techniques...
Colour video monitors....
Medicine Products: