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Ethicon Endo-Surgery Extends Research Partnership with $13.5 Million Grant to University of Cincinnati
Date:6/22/2010

laparoscopic greater curvature plication (LGCP), work. Including this new grant, the EES MARS initiative has invested more than $33M with UC and the GI Metabolism Laboratory and Weight Center at the MGH, where Lee Kaplan, M.D., Ph.D., is leading research into understanding the mechanisms of action in Roux-en-Y gastric bypass surgery.

This past Sunday, Seeley presented data and findings, which stem from the MARS initiative, on the mechanism of action of VSG during an educational course for physicians attending ASMBS,  illustrating a greater understanding of how the procedure impacts physiological factors contributing to body weight regulation and resolution of co-morbid conditions. Also at ASMBS, EES will highlight research from the GI Metabolism Laboratory and Weight Center at the MGH during a presentation and educational event.

"If we can truly understand the physiology behind how bypass surgery works, we can leverage this knowledge to create less invasive devices and procedures, creating a variety of weight loss options," said Dr. Kaplan, director of the GI Metabolism Laboratory and Weight Center at the MGH. "Finding ways to 'bypass the bypass' is a very exciting area of research that we hope will deliver options that are well suited for the large percentage of obesity sufferers who aren't currently receiving treatment."

Preliminary MARS results have been, and will continue to be, shared this year at several diverse clinical and scientific conferences. Recently, data were presented at Digestive Disease Week (DDW) 2010 by researchers from the GI Metabolism Laboratory and Weight Center at the MGH that demonstrated Roux-en-Y Gastric Bypass (RYGB) accelerated an increase in circulating levels of certain bile acids following meals. Because these bile acids have previously been shown to activate thermogenesis
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SOURCE Ethicon Endo-Surgery, Inc. (EES)
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