Navigation Links
Ethicon Endo-Surgery Extends Research Partnership with $13.5 Million Grant to University of Cincinnati

LAS VEGAS, June 22 /PRNewswire/ -- Ethicon Endo-Surgery, Inc. (EES) today announced it has renewed its research collaboration agreement with the University of Cincinnati (UC) and its Metabolic Diseases Institute (MDI). The three-year, $13.5M grant extension, is part of the EES Metabolic Applied Research Strategy (MARS), which also includes research from GI Metabolism Laboratory and Weight Center at the Massachusetts General Hospital (MGH).  The MARS initiative is aimed at improving the understanding of the physiological changes resulting from bariatric surgery. EES will highlight findings and potential implications of this research from both institutions this week at the annual meeting of the American Society for Metabolic and Bariatric Surgery (ASMBS).

(Photo: )

(Photo: )

(Photo: )

(Photo: )

(Photo: )

(Photo: )

With an estimated 300 million adults worldwide categorized as clinically obese(i), the overarching goal of the MARS initiative is to develop additional, less invasive treatment options and improved outcomes for people with obesity. Current surgical intervention options for patients with obesity have been shown to resolve Type II diabetes in a significant number of patients (78 percent of gastric bypass patients(ii) and 73 percent in banding patients(iii)) and may result in weight loss of 81 percent of their excess weight as early as 12 months after surgery.(iv) However, these techniques have resulted in weight loss that exceeds the amount expected based on reduced caloric intake alone. MARS research is underway to explain this discrepancy.

At UC's MDI, Randy Seeley, Ph.D. is leading efforts aimed at increasing the understanding of why other metabolic procedures, such as vertical sleeve gastrectomy (VSG) and laparoscopic greater curvature plication (LGCP), work. Including this new grant, the EES MARS initiative has invested more than $33M with UC and the GI Metabolism Laboratory and Weight Center at the MGH, where Lee Kaplan, M.D., Ph.D., is leading research into understanding the mechanisms of action in Roux-en-Y gastric bypass surgery.

This past Sunday, Seeley presented data and findings, which stem from the MARS initiative, on the mechanism of action of VSG during an educational course for physicians attending ASMBS,  illustrating a greater understanding of how the procedure impacts physiological factors contributing to body weight regulation and resolution of co-morbid conditions. Also at ASMBS, EES will highlight research from the GI Metabolism Laboratory and Weight Center at the MGH during a presentation and educational event.

"If we can truly understand the physiology behind how bypass surgery works, we can leverage this knowledge to create less invasive devices and procedures, creating a variety of weight loss options," said Dr. Kaplan, director of the GI Metabolism Laboratory and Weight Center at the MGH. "Finding ways to 'bypass the bypass' is a very exciting area of research that we hope will deliver options that are well suited for the large percentage of obesity sufferers who aren't currently receiving treatment."

Preliminary MARS results have been, and will continue to be, shared this year at several diverse clinical and scientific conferences. Recently, data were presented at Digestive Disease Week (DDW) 2010 by researchers from the GI Metabolism Laboratory and Weight Center at the MGH that demonstrated Roux-en-Y Gastric Bypass (RYGB) accelerated an increase in circulating levels of certain bile acids following meals. Because these bile acids have previously been shown to activate thermogenesis (the production of heat) in muscle and brown adipose tissue, the researchers concluded that this accelerated response from patients who have undergone RYGB may be linked to the increased energy expenditure. This conclusion provides valuable insight into how RYGB works and may lead researchers to novel treatments that are less invasive but still deliver both weight loss and metabolic improvements.

"Ethicon Endo-Surgery is committed to collaborating with clinicians to develop new, comprehensive bariatric solutions while also ensuring that people with obesity have access to current treatment options that can help them achieve sustained weight loss and reduce co-morbidities," said Karen Licitra, group Chairperson, Ethicon Endo-Surgery. "Due to the incredible research being performed at institutions such as UC and MGH, the MARS program is yielding very exciting results that are changing our understanding of how bariatric surgery works.  We strongly believe continued efforts in this area will dramatically improve our collective ability to treat obesity and metabolic diseases."

MARS Research at ASMBS and American Diabetes Association Annual Meetings

Dr. Kaplan will discuss the MARS initiative and potential implications for bariatric surgery at the EES booth (#403) on Thursday, June 24, at 9:45 a.m. Dr. Kaplan will also present to ASMBS attendees during the evening of Tuesday, June 22, at an EES-sponsored event that will feature a panel of experts discussing a variety of important topics, including metabolics, new technology and revision surgery.

New ways to prevent and treat obesity and diabetes will also be a central focus at the upcoming American Diabetes Association annual meeting June 25-29 in Orlando, Florida. Dr. Kaplan will discuss data from the MARS initiative and advances in metabolic surgery during a continuing medical education (CME) symposium on biological and mechanical treatments of diabetes, sponsored in part by an educational grant from EES.

About Ethicon Endo-Surgery

Ethicon Endo-Surgery develops and markets advanced medical devices for minimally invasive and open surgical procedures, focusing on procedure-enabling devices for the interventional diagnosis and treatment of conditions in general and bariatric surgery, as well as gastrointestinal health, gynecology and surgical oncology. More information can be found at  

(i) World Health Organization. Global Strategy on Diet, Physical Activity and Health. 2003.

(ii) Buchwald, H. et al. Weight and Type 2 Diabetes after Bariatric Surgery: Systematic Review and Meta-analysis. American Journal of Medicine. 2009; 122(3): 205-206.

(iii) Dixon, JB et al. Adjustable Gastric Banding and Conventional Therapy for Type 2 Diabetes. Journal of the American Medical Association. 2008; 299(3): 316-323.

(iv) Wittgrove, AC, et al. Laparoscopic Gastric Bypass, Roux-en-Y: Technique and Results in 75 Patients With 3-30 Months Follow-up. Obesity Surgery 1996: 6, 500-504

SOURCE Ethicon Endo-Surgery, Inc. (EES)
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Ethicon Endo-Surgery Studies Presented at DDW Demonstrate Potential of Pure NOTES Surgery With Companys Toolbox
2. First Patient of NOTES Investigational Device Exemption (IDE) Study Successfully Treated With Ethicon Endo-Surgery Devices
3. Ethicon Endo-Surgery Wins Prestigious International Design Award for Innovative Development of HARMONIC FOCUS(TM)
4. Ethicon Endo-Surgery Launches New Echelon Flex(TM) Endopath(R) Stapler That Delivers Echelon(TM) Compression, Now With Natural Articulation
5. Ethicon Endo-Surgery Unveils Full Energy Portfolio for First Time at American College of Surgeons Clinical Congress
6. Ethicon Endo-Surgery Introduces Innovation-Enabling Solutions Across the Spectrum of Surgery at ACS
7. Ethicon Completes Acquisition of Acclarent
8. Ethicon Announces Definitive Agreement to Acquire Acclarent
9. Ethicon Endo-Surgery Announces Agreement with Hologic Inc. To Resolve Patent Disputes
10. Ethicon Endo-Surgery SEDASYS(R) System Receives Regulatory Approval in Canada and CE Mark in European Union
11. Ethicon Endo-Surgery Introduces HARMONIC FOCUS(R) Long Curved Shears for Deep Surgical Access
Post Your Comments:
(Date:10/13/2015)... , Oct. 13, 2015 Health Gorilla ( ... Clinical Network – a secure platform for clinical data ... patients interact about and manage healthcare in the US. The ... round, for a combined total of $4.4M raised to date, ... from True Ventures , Harris Barton , ...
(Date:10/13/2015)... -- Research and Markets ( ) has announced ... Cosmetics Packaging - Market Opportunities and Forecasts, 2014 - ... --> --> The anti-counterfeit pharmaceutical ... of 15.7% during 2015-2020 --> ... for about 52% share in 2014 and would continue ...
(Date:10/12/2015)... the United States . By early next year, ... the United States . By early next year, ... The University of Texas MD Anderson Cancer Center, Elekta and ... Tesla) MRI-guided linear accelerator in the United States ... a non-clinical capacity. Royal Philips (NYSE: PHG ...
Breaking Medicine Technology:
(Date:10/13/2015)... ... October 13, 2015 , ... ... that targets the unique health needs of new moms. Postnatal Omega-3, which ... ( ), utilizes Nordic Naturals’ exclusive, new, ultra-concentrated omega-3 oil. This ...
(Date:10/13/2015)... ... October 13, 2015 , ... T-System and Centegra ... than 59,000 emergency department visits per year, today announced the successful and rapid ... improve clinical, operational and financial outcomes. , In less than four ...
(Date:10/13/2015)... ... ... Tempe Dental Care, a leading Tempe dentists’ office, celebrates offering gentle, pain free ... more than 5 years. A leading cause of emergency room visits, school absences, and ... timely. , Sedation dentistry provides an anxiety-free dental experience with safe ...
(Date:10/13/2015)... Miami, FL (PRWEB) , ... October 13, 2015 , ... ... announces the Driveway Snow Blanket, a snow melting invention that helps people in clearing ... $17 billion and will continue to grow at 3.8% per year," says Scott Cooper, ...
(Date:10/13/2015)... , ... October 13, 2015 , ... According to an ... suffered an orbital fracture when a teammate accidentally elbowed him in the left eye ... recent eye injury is just one of a series of setbacks, including a knee ...
Breaking Medicine News(10 mins):