Navigation Links
Established Safety Profile of Spiriva Confirmed by 30 Rigorously Controlled Clinical Trials and the Landmark Trial UPLIFT
Date:9/23/2008

CI = 0.79, 1.35), and

-- No increased risk for myocardial infarction (relative risk ratio for

myocardial infarction 0.78, 95% CI = 0.59, 1.02) associated with

tiotropium.(3)

The UPLIFT results demonstrate that there is no increased risk of total mortality or cardiovascular mortality in COPD patients treated with Spiriva.

"We strongly disagree with the conclusion reached by Singh et al. We have disclosed to regulatory authorities worldwide this important information, which is part of a very robust analysis of all our double-blind, placebo-controlled, parallel group trials with a duration of at least 4 weeks. Our analysis, which includes data from the four-year UPLIFT trial, supports the safety profile of Spiriva," commented Dr Andreas Barner, Vice Chairman of the Board of Managing Directors at Boehringer Ingelheim, responsible for Research, Development and Medicine. "Patients and physicians can be confident that Spiriva is a safe and effective medication. In clinical trials and since its introduction, we have collected extensive safety data adding up to an exposure of more than 10 million patient years."

Peer-reviewed meta-analyses of aggregate published data like Singh et al have their appropriate place in scientific research. However, these analyses have well-recognized limitations, such as combining study summaries rather than analyzing individual patient data, or not correcting for patients who dropped out of trials early.

Most of the evidence in the analysis by Dr. Singh and colleagues is contributed by a single study, the Lung Health Study, involving a different anticholinergic medication, ipratropium. In this study, most of the cardiovascular deaths occurred among patients who were not using their medication. Other limitations include the inability to adjust for treatment duration and accounting for patients who discontinue the trial early, apparent double-counting of trials and combining placebo and
'/>"/>

SOURCE Boehringer Ingelheim; Pfizer Inc
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. New Studies Confirm Safety, Effectiveness of Balloon Sinuplasty(TM) Technology for Chronic Sinusitis
2. Nutrition 21 Reports That National Toxicology Program Studies Support the Safety of Chromium Picolinate
3. 338 Patient Pivotal Trial Demonstrates Safety and Effectiveness of Polidocanol Sclerotherapy Product for Varicose Vein Treatment
4. Catheter Ablation System for Atrial Fibrillation Shows Reduced Procedure Time, Remarkable Safety Profile and Excellent Outcomes in Two Clinical Studies
5. Biosensors DES Demonstrates Equivalent Safety and Efficacy to Industry Leading DES in First Real World, All Comers Clinical Study
6. NicOx Announces Top-Line Results From Naproxcinod 52-Week 301 Safety Extension
7. FluoroPharma Announces Positive Phase I Safety Results for BFPET(TM), Myocardial Perfusion Imaging (MPI) Tracer for Positron Emission Tomography (PET)
8. Secretary Reinforces VAs Commitment to Research Safety and Veteran Focus
9. AlphaDetail AlphaPulse(TM): Most Practicing Physicians React Positively to FDA Panels Recommendation for Additional Cardiovascular Safety Trials for New Diabetes Medications.
10. Studies of an Innovative Catheter Ablation System for Atrial Fibrillation Reveal Excellent Outcomes, Safety Profile and Fast Procedure Times
11. Micromet and Nycomed Begin Formal Preclinical Safety Studies for Antibody MT203 for Inflammatory and Autoimmune Diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)...  When Ryan Rendino first felt the ... neck, he figured it was a muscle ... from weight lifting. But the ... A series of doctor appointments followed ... Michel Kliot, MD , a Northwestern ...
(Date:5/21/2015)... 2015  CryoLife, Inc. (NYSE: CRY ), a ... cardiac and vascular surgery, announced today that its Board ... the second quarter 2015 of $0.03 per share of ... per share will be paid on June 19, 2015 ... 12, 2015.  The ex-dividend date for the quarterly dividend ...
(Date:5/21/2015)... Mai 2015 Dipexium Pharmaceuticals, ... Unternehmen für Arzneimittel im fortgeschrittenen Entwicklungsstadium, ... Vermarktung von Locilex® (Pexiganan-Creme 0,8 %) und ... wissenschaftliche Posterpräsentation an, welche das innovative ... OneStep-1 und OneStep-2, in der Locilex® ...
Breaking Medicine Technology:Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 2Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 3Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 4CryoLife Announces Quarterly Cash Dividend for the Second Quarter 2015 2Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 2Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 3Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 4Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 5Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 6Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 7
... a global leader in minimally invasive cryotherapy treatments for ... establishing its new Global Headquarters in Minneapolis, MN. ... in Arden Hills during the fourth quarter of 2009. ... functions, the company will also locate its global marketing, ...
... alternative therapy for Parkinson,s , NEW YORK, Sept. 30 ... Center have reached a milestone in the development of potential ... of current therapy. , The team, which received an MJFF ... LEAPS (Linked Efforts to Accelerate Parkinson,s Solutions) initiative, ...
Cached Medicine Technology:Galil Medical Announces Establishment of Global Headquarters in Minneapolis, MN 2Michael J. Fox Foundation-Funded Team Pursuing Glutamate-Based Treatment for Parkinson's Disease Hits Major Milestone 2
(Date:5/24/2015)... Indiana Fiber Network, LLC (IFN), the ... of America, Inc. (MTA) has selected IFN as a ... IFN Enterprise Sales Manager, fiber route diversity and network ... transport provides MTA with the diverse fiber transport from ... Internet and voice carriers located at Henry Street in ...
(Date:5/23/2015)... On May 13, Nithyananda Yoga Foundation organized ... power learned through meditation and initiation at Special Holistic ... , Yogamaatha, a nine-year-old girl from North Carolina, stunned ... attending the 2015 Business Advocacy Summit at Capitol Hill ... , In a demonstration that lasted three hours, Yogamaatha ...
(Date:5/23/2015)... (PRWEB) May 23, 2015 Manufacturers are now ... Performance Factor (HSPF) of 8.2. Experts in the field agree ... benefit consumers. , The HSPF score is what miles per ... more efficient the unit. Although the minimum HSPF score has ... heaters with an HSPF score north of 12. Indeed, the ...
(Date:5/22/2015)... Calif. (PRWEB) May 22, 2015 ... technology, communication and capacity are intersecting to create ... across society, the opening speaker at WesternU's 34th ... California Lieut. Gov. Gavin Newsom, a former San ... the keynote speaker at the graduation ceremony for ...
(Date:5/22/2015)... New York (PRWEB) May 22, 2015 ... ) filed on behalf of individuals who allegedly ... to its use continue to move forward in ... According to a Pretrial Order dated May 4, ... preservation of documents and electronically stored information. Among ...
Breaking Medicine News(10 mins):Health News:Indiana Fiber Network, LLC Enables Midwest Telecom of America with Fiber Route Diversity 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 3Health News:Parker & Sons Welcomes the Department of Energy’s Water Heater Regulation 2Health News:Newsom to WesternU Grads: The Future is Inside You 2Health News:Newsom to WesternU Grads: The Future is Inside You 3Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 3Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 4
... finds no connection between the two , , MONDAY, Jan. ... of evidence that rejects the idea that immunizations boost ... incidences of the disorder dropped after makers of most ... products. , Researchers found that autism rates in California ...
... prescriptions for children and adults , , MONDAY, Jan. 7 ... thoughts and behaviors in young people who take antidepressants ... research suggests. , The U.S. Food and Drug Administration ... selective serotonin reuptake inhibitors (SSRIs) might increase the risk ...
... for Emageon presentation, BIRMINGHAM, Ala., Jan. 7 ... in enterprise medical information technology,systems for hospitals, healthcare ... Chairman, CEO and President, will present at the,26th ... January 7-10, 2008,at the Westin St. Francis Hotel ...
... PARK, Calif., Jan. 7 ForSight Labs, LLC announced,today ... VISION3,Inc. with a Series A financing of $6 million, ... the medical technology arena: Morgenthaler,Ventures, Split Rock Partners and ... a significant round of funding to,develop our next innovative ...
... Va., Jan. 7 Specialty Blades, Inc. and ... completed its,acquisition of Popper and Sons, Inc. The ... tubing medical device manufacturing company,makes the combined company ... for the medical device industry. Specialty Blades,originally announced ...
... kept exam dates, study finds , , MONDAY, Jan. 7 ... time in the short-term, people who do so tend not ... Time saved with an Internet purchase may translate into ... that people purchasing lenses from wholesale clubs or optical chains ...
Cached Medicine News:Health News:Study Casts Doubt on Vaccine-Autism Link 2Health News:Study Casts Doubt on Vaccine-Autism Link 3Health News:Youth Suicide Warnings Are Slowing Antidepressant Sales 2Health News:ForSight Labs, LLC Announces Formation of Its Third Company, ForSight VISION3, Inc. and Closing of $6 Million in Series A Funding 2Health News:ForSight Labs, LLC Announces Formation of Its Third Company, ForSight VISION3, Inc. and Closing of $6 Million in Series A Funding 3Health News:Eye Care Lacking in Many Who Buy Contact Lenses Online 2
Micro instruments designed to provide maximum grasping, resecting capability, and excellent maneuverability for easy access to tight, small joints (wrist, elbow, and ankle).,Features pinless hinge d...
... The Stryker Cross-Screw System offers ... secure method for ACL reconstruction ... Stryker Cross-Screw System provides the ... The implant comes in Titanium ...
The Stryker Bioabsorbable Wedge Interference Screw is made of Poly-L Lactic Acid (PLLA). The patented wedge design makes it perfect for cruciate reconstruction and is indicated for BTB and soft tissu...
The Stryker Shoulder Instrumentation Set is ideal for open and arthroscopic shoulder procedures. The kit includes all the necessary tools for bone and tissue preparation as well as suture management ...
Medicine Products: