Essentialis to Submit SPA for Hypertrigl...(2789 containing claims to DCCR was issue...),Health

Date:8/11/2009

2,789, containing claims to DCCR, was issued on August 11, 2009. Additional applications filed in the US and globally will further enhance the patent portfolio. Phase 2 and pivotal studies of DCCR in combination with a statin for the treatment of high triglycerides (TG between 200 and 500 mg/dL) are planned, and study synopses have been provided to the FDA.

About Hypertriglyceridemia

Very high triglycerides (TG greater than or equal to 500mg/dL) are a risk factor for developing pancreatitis. There are approximately 3.8 million patients in the US with very high triglycerides. The leading products for treating very high triglycerides are fenofibrate and omega-3 fatty acids. While effective, these compounds cause significant elevations in LDL-C. High triglycerides (TG between 200 and 500 mg/dL) are a risk factor for coronary heart disease even after LDL-C targets have been achieved.

About Essentialis, Inc.

Essentialis, Inc. is a pharmaceutical company based in Carlsbad, CA. The Company's products are targeted at the ATP-sensitive potassium channel, a metabolically-regulated membrane protein whose modulation has the potential to impact a wide range of cardiovascular and metabolic diseases. The Company's lead product, DCCR, is set to commence pivotal studies in subjects with very high triglycerides. Essentialis is actively exploring its partnering options for DCCR.

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SOURCE Essentialis, Inc. Copyright©2009 PR Newswire. All rights reserved

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